2024
DOI: 10.1021/acs.jpclett.4c02764
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Accelerated Amyloid Aggregation Dynamics of Intrinsically Disordered Proteins in Heavy Water

Myung Kook Son,
Dongjoon Im,
Da Gyeong Hyun
et al.

Abstract: We explored the influence of D 2 O on the fibrillation kinetics and structural dynamics of amyloid intrinsically disordered proteins (IDPs), including α-synuclein, amyloid-β 1−42, and K18. Our findings revealed that fibrillation of IDPs was accelerated in D 2 O compared to that in H 2 O, exhibiting faster kinetics in contrast to the structured protein, insulin. Structural investigations using electrospray ionization ion mobility mass spectrometry and small-angle Xray scattering combined with molecular dynamics… Show more

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