Accelerated Atherosclerosis in Systemic Lupus Erythematosus: Role of Proinflammatory Cytokines and Therapeutic Approaches

Frieri, Marianne

doi:10.1007/s11882-011-0236-1

Cited by 42 publications

(30 citation statements)

References 18 publications

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“…NF-κB has a direct role with many different diseases such as sepsis, HIV [15,16] hypogammaglobulinemia [17], rhinosinusitis [18], rheumatoid arthritis, systemic lupus erythematosis [19], and lupus nephritis [20]. BTKdependent activation in hypogammaglobulinemia is related to NF-κB, essential for reprogramming the expression of genes that control B cell survival and proliferation [17] and D Pteronyssinusi-induced apoptosis-related rhinosinusitis can occur [18].…”

Section: Introductionmentioning

confidence: 99%

Role of Nuclear Factor-ĸB in Breast and Colorectal Cancer

Zubair¹,

Frieri

2012

Curr Allergy Asthma Rep

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The purpose of this review article is to highlight articles and new research regarding the link between NF-ĸB and several cancers. This review presents the most up-to-date NF-ĸB research and how it links this important transcription factor with hematology and oncology. It was written by conducting a thorough search of Pubmed as well as several journals such as Cancer, Nature, Science, Cell and those of one of the authors. The articles relating to the link between NF-ĸB and cancer were used to write this review. The results of this study clarified that there is a critical link between NF-ĸB and cancer. NF-ĸB has often been implicated in a variety of different diseases and it plays a variety of roles in cell survival, differentiation, and proliferation of cells. In cancer, NF-ĸB plays a pivotal role by facilitating oncogenesis as well as metastasis. A thorough understanding of NF-ĸB and its role in cancer can lead to future studies and drug development which could provide a novel option in the treatment of this disease.

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Section: Introductionmentioning

confidence: 99%

Role of Nuclear Factor-ĸB in Breast and Colorectal Cancer

Zubair¹,

Frieri

2012

Curr Allergy Asthma Rep

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“…SI in patients with SLE is mostly caused by arterial thrombosis, promoted by autoantibody-induced endothelial injury [3,7]. Elevated levels of proinflammatory cytokines and chemokines also facilitates the thrombotic process [8]. As a result, the lifetime incidence rate of thrombosis among patients with SLE is estimated to be 9 -37 %.…”

Section: Discussionmentioning

confidence: 99%

Splenic infarct presenting as acute chest pain

Pak¹,

As²

2017

Vascul Dis Ther

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Splenic infarct (SI) is a rare clinical diagnosis typically characterized by symptoms of abdominal pain, nausea, and vomiting. Here we provide a unique case of SI, presenting as acute left-sided chest pain. This unusual presentation led us to incorrectly focus the initial investigation on diseases of cardiac origin. The resultant delay in correct diagnosis of Splenic Infarct and adequate treatment is described. This case highlights the need to consider SI in patients with acute chest pain, particularly in the presence of predisposing factors, such as hematological malignancy or autoimmune rheumatic diseases.

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“…Patients with SLE are 2 to 9 times more likely than the general population to have myocardial infarctions 2,3,4 . The pathogenesis is multifactorial, including traditional cardiovascular risk factors, but also corticosteroids and inflammatory pathways 5,6,7,8 . The risk of an acute cardiac event is affected by the presence, extent, location, characteristics, and metabolic activity of coronary atherosclerotic plaque 13,14,15 .…”

Section: Systemic Lupus Erythematosus; Cardiovascular Disease; Risk Fmentioning

confidence: 99%

“…The pathogenesis is multifactorial, including traditional cardiovascular risk factors, but also corticosteroids and inflammatory pathways 5,6,7,8 .…”

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confidence: 99%

Semiquantified Noncalcified Coronary Plaque in Systemic Lupus Erythematosus

2012

J Rheumatol

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Objective-A major cause of morbidity and mortality in systemic lupus erythematosus (SLE) is accelerated coronary atherosclerosis. New technology (computed tomographic angiography) can measure noncalcified coronary plaque (NCP), which is more prone to rupture. We report on a study of semiquantified NCP in SLE.Methods-Patients with SLE (n = 147) with no history of cardiovascular disease underwent 64-slice coronary multidetector computed tomography (MDCT). The MDCT scans were evaluated quantitatively by a radiologist, using dedicated software.Results-The group of 147 patients with SLE was 86% female, 70% white, 29% African American, and 3% other ethnicity. The mean age was 51 years. In our univariate analysis, the major traditional cardiovascular risk factors associated with noncalcified plaque were age (p = 0.007), obesity (p = 0.03; measured as body mass index), homocysteine (p = 0.05), and hypertension (p = 0.04). Anticardiolipin (p = 0.026; but not lupus anticoagulant) and anti-dsDNA (p = 0.03) were associated with higher noncalcified plaque. Prednisone and hydroxychloroquine therapy had no effect, but methotrexate (MTX) use was associated with higher noncalcified plaque (p = 0.0001). In the best multivariate model, age, current MTX use, and history of anti-dsDNA remained significant. Conclusion-Our results suggest that serologic SLE (anti-dsDNA) and traditional cardiovascular risk factors contribute to semiquantified noncalcified plaque in SLE. The association with MTX is not understood, but should be replicated in larger studies and in multiple centers. Key Indexing Terms SYSTEMIC LUPUS ERYTHEMATOSUS; CARDIOVASCULAR DISEASE; RISK FACTORS; COMORBIDITYCardiovascular disease, specifically from accelerated premature atherosclerosis, is a major cause of morbidity and mortality in systemic lupus erythematosus (SLE) 1 . Patients with SLE are 2 to 9 times more likely than the general population to have myocardial infarctions 2,3,4 . The pathogenesis is multifactorial, including traditional cardiovascular risk factors, but also corticosteroids and inflammatory pathways 5,6,7,8 . The risk of an acute cardiac event is affected by the presence, extent, location, characteristics, and metabolic activity of coronary atherosclerotic plaque 13,14,15 . Noncalcified plaque may be more metabolically active than highly calcified plaque and preliminary data suggest that the presence of noncalcified or only partially calcified plaques is associated with greater risk of unstable presentation 16 . Motoyama, et al reported that the appearance of low attenuation plaque on multidetector CT was an independent predictor of acute coronary syndrome events for a 2-year followup period 17 . Noncalcified plaque may be present in the absence of coronary artery calcification: in a Japanese study, the prevalence of noncalcified plaque was 11.1% in patients with no coronary artery calcium and 23.4% in patients with mild coronary artery calcium 18 .In our previous study of noncalcified plaque in SLE, we found that 54% of patients with SLE h...

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Accelerated Atherosclerosis in Systemic Lupus Erythematosus: Role of Proinflammatory Cytokines and Therapeutic Approaches

Cited by 42 publications

References 18 publications

Role of Nuclear Factor-ĸB in Breast and Colorectal Cancer

Role of Nuclear Factor-ĸB in Breast and Colorectal Cancer

Splenic infarct presenting as acute chest pain

Semiquantified Noncalcified Coronary Plaque in Systemic Lupus Erythematosus

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