Accelerated Development of AAV Purification Process Using a High-Throughput and Automated Crossflow System
Sónia Mendes,
Tiago Q. Faria,
André Nascimento
et al.
Abstract:Adeno-associated viruses (AAV) are currently predominant viral transfer tools for gene therapy, and efforts are being made to design faster and more efficient methods and technologies for their manufacturing. The early selection of high-performing filters is essential for developing an ultrafiltration and diafiltration (UF/DF) process, especially when feed material is scarce, and timelines are short. However, few methods and technologies exist to enable process optimization with multiple variations in a single… Show more
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