Accelerated Drying of Corn

Pickett, L. K.; Pinkerton, James; Yoerger, R. R.; Jensen, A. H.

doi:10.13031/2013.40852

Cited by 1 publication

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“…Despite the significant number of amino acid differences between these two toxins, AI fragments of LT-IIa and LTh-I, both of which have ADP-ribosylating activity, exhibited 64% homology at the amino acid level. Conservation of the ADP-ribosylating activity of the AI fragments of LT-1, CT and LT-II suggests a strong selective pressure for this enzymatic activity [18]. Likewise, it is conceivable that a short segment of the amino acid sequence which has ADP-ribosylating activity might have been conserved in the cytotonic enterotoxin gene(s) of Aeromonas.…”

Section: Mechanism Of Action Of Cytotonic Enterotoxinmentioning

confidence: 99%

Mechanism of action of a cytotonic enterotoxin produced by Aeromonas hydrophila

Chopra

Houston

1992

FEMS Microbiology Letters

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In this study, we describe the mechanism of action of a cytotonic enterotoxin produced by two isolates of Aeromonas hydrophila. Isolates SSU and Ah65 are of different origin and both are capable of producing either a cytotoxic enterotoxin or aerolysin. A cytotonic enterotoxin produced by diarrheal isolate SSU, which was purified and characterized in our laboratory, elevated intracellular cAMP and PgE2 levels in cultured Chinese hamster ovary (CHO) cells. Likewise, enterotoxic activity expressed by a cytotonic enterotoxin was detected in the culture filtrate of a fish isolate (Ah65) after cytotoxic activity was neutralized with homologous aerolysin monoclonal antibodies. This cytotonic enterotoxin also elevated intracellular cAMP and PgE2 levels in CHO cells, suggesting a cholera toxin‐like mechanism of action for Aeromonas cytotonic enterotoxins.

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Section: Mechanism Of Action Of Cytotonic Enterotoxinmentioning

confidence: 99%