Accelerated Neuroimmune Dysfunction in Aged HIV-1-Infected Humanized Mice
Chen Zhang,
Hang Su,
Emiko Waight
et al.
Abstract:Disordered immunity, aging, human immunodeficiency virus type one (HIV-1) infection, and responses to antiretroviral therapy are linked. However, how each factor is linked with the other(s) remains incompletely understood. It has been reported that accelerated aging, advanced HIV-1 infection, inflammation, and host genetic factors are associated with host cellular, mitochondrial, and metabolic alterations. However, the underlying mechanism remains elusive. With these questions in mind, we used chronically HIV-… Show more
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