Accelerated Partial Breast Irradiation: A Review and Description of an Early North American Surgical Experience with the Intrabeam Delivery System

Deneve, Jeremiah L.; Hoefer, Richard; Harris, Eleanor; Laronga, Christine

doi:10.1177/107327481201900406

Cited by 23 publications

(16 citation statements)

References 108 publications

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“…At the present time, external beam IORT is administered by a dedicated linear accelerator with parallel electron beams of 3–12 MeV kinetic energy or isotropic photon fields with energies between contact and superficial therapy of 50 kV X-rays (38). Such low photon energy beams (e.g., Intrabeam ® by Carl Zeiss AG, Germany) have demonstrated favorable outcomes in some sites but with many questions remaining unanswered (39, 40). …”

Section: Modalities For Iortmentioning

confidence: 99%

Intraoperative Radiation Therapy: A Promising Treatment Modality in Head and Neck Cancer

et al. 2017

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Every year, almost 62,000 are diagnosed with a head and neck cancer (HNC) and 13,000 will succumb to their disease. In the primary setting, intraoperative radiation therapy (IORT) can be used as a boost in select patients in order to optimize local control. Addition of external beam radiation to limited volumes results in improved disease control over surgery and IORT alone. In the recurrent setting, IORT can improve outcomes from salvage surgery especially in patients previously treated with external beam radiation. The use of IORT remains limited to select institutions with various modalities being currently employed including orthovoltage, electrons, and high-dose rate brachytherapy. Practically, execution of IORT requires a coordinated effort and careful planning by a multidisciplinary team involving the head and neck surgeon, radiation oncologist, and physicist. The current review summarizes common uses, outcomes, toxicities, and technical aspects of IORT in HNC patients.

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Section: Modalities For Iortmentioning

confidence: 99%

Intraoperative Radiation Therapy: A Promising Treatment Modality in Head and Neck Cancer

et al. 2017

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“…The surgical technique for IORT with the Intrabeam system has been previously described. 9 Briefly, all patients underwent preoperative tumor localization by either ultrasound or stereotactic guidance, and radiotracer injection for sentinel lymph node biopsy (SLNB). All patients received a single dose of preoperative antibiotics.…”

Section: Methodsmentioning

confidence: 99%

Intraoperative radiotherapy for early breast cancer and age: clinical characteristics and outcomes

Abbott

Dossett

Loftus

et al. 2015

The American Journal of Surgery

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“…The lymph nodes (LN) can function as “filters” to remove cancer cells from the systemic circulatory system. The regional immune responses within LNs during cancer progression can be an important prognostic indicator and LN response often serves as a critical criterion for evaluating therapeutic response(Deneve et al, 2012; Lee et al, 2012),(Kimber et al, 2000; Helle et al, 2012; Noh et al, 2012). Infection and/or tumor cell migration commonly leads to increases in LN size.…”

Section: Instroductionmentioning

confidence: 99%

High resolution MRI for non-invasive mouse lymph node mapping

Zhang

Procissi

et al. 2013

Journal of Immunological Methods

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Mouse models are fundamental to the study and design of new techniques for the cancer diagnosis and treatment. The lymphatic system plays an active role in oncogenesis and metastatic disease progression. However, the in vivo identification of LNs in mice is challenging with conventional imaging modalities since the LN diameter in normal mice is 1–2 mm. Standard dissection techniques are challenging and can only provide endpoint data. Here, we describe high resolution MRI (HR-MRI) approaches for the non-invasive detection of mouse LNs in vivo. We compare in vivo non-invasive HR-MRI methods (without exogenous contrast injections) to the ex vivo dye injection methods for the identification of commonly studied LNs in both normal mice and a mouse model of pancreatic ductal adenocarcinoma (PDAC). We demonstrated the potential to use HR-MRI techniques as a non-invasive imaging assay for visualizing mouse LNs in vivo.

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Accelerated Partial Breast Irradiation: A Review and Description of an Early North American Surgical Experience with the Intrabeam Delivery System

Cited by 23 publications

References 108 publications

Intraoperative Radiation Therapy: A Promising Treatment Modality in Head and Neck Cancer

Intraoperative Radiation Therapy: A Promising Treatment Modality in Head and Neck Cancer

Intraoperative radiotherapy for early breast cancer and age: clinical characteristics and outcomes

High resolution MRI for non-invasive mouse lymph node mapping

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