Accelerated solvent extraction coupled to high‐performance liquid chromatography–tandem mass spectrometry for simultaneous determination of 11 organophosphorus flame retardants in aquatic products

Suo, Lili; Huang, Weihua; Qunying, Zhu; Ma, Lan; Hu, Meihua

doi:10.1002/jsfa.9067

Cited by 10 publications

(3 citation statements)

References 34 publications

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“…This technology has higher extraction efficiency, but substantial investment in equipment and laborious selection of entrainers limited its development [8]. ASE method extracts solid or semisolid samples with liquid solvents under high temperature (50-200 8C) and pressure (6.9-20.7 MPa) [9]. High temperature and pressure of solvent increase the ability of solubilizing the analyte, therefore, this technology shows good extraction results in the analysis of residual pesticides in food [10].…”

Section: Introductionmentioning

confidence: 99%

Application of ultrasound-assisted deep eutectic solvent extraction combined with liquid-liquid extraction method to the extraction of three pesticide residues from fruit and vegetable samples

Chen¹,

An²,

Sun³

et al. 2020

AChrom

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Abstract A simple, inexpensive and sensitive method was developed for the simultaneous determination of three pesticide residues (carbendazim, thiophanate-methyl, and imidacloprid) in fruit and vegetable samples using high performance liquid chromatography (HPLC) based on a combined pretreatment of ultrasound-assisted deep eutectic solvent extraction (UA-DES-E) and liquid-liquid extraction (LLE). In this study, various types of deep eutectic solvents (DESs) were synthesized and the extraction efficiency was compared as extraction solvents. Results showed that glycerol-proline = 9:4 (GP-5) obtained the highest extraction efficiency among different types of DESs. Experiment conditions, including DES volume, extraction time and pH, were systematically optimized using single-factor experiment. Under the optimum conditions, the limits of detection (LODs) and quantification (LOQs) were in the ranges of 0.05–0.2 μg·mL−1 and 0.1–0.5 μg·mL−1, respectively. The relative recoveries of the three pesticides in the fruit and vegetable samples ranged from 85.7 to 113.0% at two spiked levels. Meanwhile, the method achieved excellent linearity with determination coefficients (r) greater than 0.999. Furthermore, the method was successfully applied to the analysis of the pesticides in real fruit and vegetable samples (apple, tomato, and grape).

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Section: Introductionmentioning

confidence: 99%

Application of ultrasound-assisted deep eutectic solvent extraction combined with liquid-liquid extraction method to the extraction of three pesticide residues from fruit and vegetable samples

Chen¹,

An²,

Sun³

et al. 2020

AChrom

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“…Therefore, it is essential to provide an efficient method for quantifying harmful pollutants such as pesticides residues in honey samples to warrant consumers' safety. 3,4 Several chromatographic methods such as highperformance liquid chromatography (HPLC), [5][6][7] liquid chromatography-tandem mass spectrometry (LC-MS-MS), 8 and gas chromatography-mass spectrometry (GC-MS) 1,9,10 have been used for OPPs analysis in different samples. Although these methods are sensitive and selective, another stage named as sample preparation is needed before instrumental analysis because of trace levels of pesticides present in the real samples.…”

Section: Introductionmentioning

confidence: 99%

Control of Organophosphorus Pesticides Residues in Honey Samples Using a Miniaturized Tandem Preconcentration Technique Coupled with High Performance Liquid Chromatography

et al. 2020

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Background:In the present work, a miniaturized sample preparation method based on combination of dispersive solid phase extraction and temperature-induced homogenous liquidliquid microextraction has been proposed for the extraction and preconcentration of some organophosphorus pesticides (parathion-methyl, triazophos, parathion, diazinon, and phoxim) from honey samples prior to their analysis by high performance liquid chromatographyultraviolet detection. Methods: In this method, initially the analytes were adsorbed onto a sorbent (C 18 ) and then desorbed by the use of cyclohexyl amine as an eluent. In the next step, the eluent was mixed with water thermostated at 0 °C to obtain a homogenous solution. By increasing the temperature, the solubility of cyclohexyl amine in water was decreased and led to formation of dispersed fine droplets in the whole of solution. These droplets go up through the solution and collected on top of the solution. Finally, an aliquot of the organic phase was sucked in a microsyringe and injected into the separation system for analysis. Results: Under the optimum experimental conditions, limits of detection and quantification were calculated to be in the ranges of 0.90-1.75 and 3.0-5.8 ng g -1 in honey samples, respectively. Enrichment factors and extraction recoveries were in the ranges of 148-183 and 59-73%, respectively. The relative standard deviations varied from 2-4% and 4-5% for intra-(n = 6) and inter-day (n = 4) precisions, respectively. Conclusion: The suggested approach was satisfactorily utilized to the analysis of 21 honey samples. The proposed miniaturized tandem sample pretreatment method enhanced the sensitivity of the instrumental analysis.

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“…HPLC-MS/MS is a highly sensitive and selective analytical technique that has become popular for the detection of OPFRs in recent years [7,[26][27][28][29]. However, the determination of OPFRs in foodstuff remains challenging due to their low concentrations and the complexity of the sample matrix.…”

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confidence: 99%

Rapid determination of 13 organophosphorus flame retardants in milk by using modified quick, easy, cheap, effective, rugged, and safe technique, solid‐phase extraction, and HPLC‐MS/MS

Chen

et al. 2021

J of Separation Science

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Organophosphorus flame retardants are a class of widely used plasticizers and flame retardants. In this study, an analytical methodology for the simultaneous determination of 13 organophosphorus flame retardants in milk was developed by using high‐performance liquid chromatography‐tandem mass spectrometry in combination with a modified quick, easy, cheap, effective, rugged, and safe technique and solid‐phase extraction. The experimental parameters of the sample purification procedure and high‐performance liquid chromatography‐tandem mass spectrometry were optimized. The developed method was validated in terms of linearity, limits of detection, recovery, and precision. The method showed a linear response in the 1–100 ng/mL concentration range and the limits of detection ranged from 0.001 to 0.3 ng/mL. The mean recoveries for most organophosphorus flame retardants were in the ranges of 75.0–115.8% (spiked at 2.5 ng/mL) and 76.7–124.8% (spiked at 25 ng/mL), with relative standard deviations of <13.09%. The developed methodology was successfully applied to the analysis of nine human milk samples and nine commercial cow milk samples. Eleven organophosphorus flame retardants were detected in the human milk samples, with median concentrations that ranged from lower than the limit of detection to 1.47 ng/mL, and only nine organophosphorus flame retardants were detected in cow milk samples, with median levels of <0.32 ng/mL.

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Accelerated solvent extraction coupled to high‐performance liquid chromatography–tandem mass spectrometry for simultaneous determination of 11 organophosphorus flame retardants in aquatic products

Abstract: The proposed method was applied successfully to detect 11 organophosphorus flame retardants in aquatic products, including grass carp, ribbon fish, mud fish, common eel, shrimp and frog. © 2018 Society of Chemical Industry.

Cited by 10 publications

References 34 publications

Application of ultrasound-assisted deep eutectic solvent extraction combined with liquid-liquid extraction method to the extraction of three pesticide residues from fruit and vegetable samples

Application of ultrasound-assisted deep eutectic solvent extraction combined with liquid-liquid extraction method to the extraction of three pesticide residues from fruit and vegetable samples

Control of Organophosphorus Pesticides Residues in Honey Samples Using a Miniaturized Tandem Preconcentration Technique Coupled with High Performance Liquid Chromatography

Rapid determination of 13 organophosphorus flame retardants in milk by using modified quick, easy, cheap, effective, rugged, and safe technique, solid‐phase extraction, and HPLC‐MS/MS

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