Accelerated Spirometric Decline in New York City Firefighters With α;1-Antitrypsin Deficiency

Banauch, Gisela I.; Brantly, Mark; Izbicki, Gabriel; Hall, Charles B.; Shanske, Alan; Chavko, Robert; Santhyadka, Ganesha; Christodoulou, Vasilios; Weiden, Michael D.; Prezant, David J.

doi:10.1378/chest.10-0187

Cited by 45 publications

(44 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Serum inflammatory biomarkers are also elevated in COPD exacerbations (49)(50)(51). We have recently reported that low a 1 -antitrypsin, elevated granulocyte-macrophage colonystimulating factor, and macrophage-derived chemokine are additional risk factors for the development of WTC-related lung injury (52)(53)(54). The contribution of the serum glucose became nonsignificant in the final model.…”

Section: Discussionmentioning

confidence: 99%

Metabolic Syndrome Biomarkers Predict Lung Function Impairment

Naveed

Weiden

Kwon

et al. 2012

Am J Respir Crit Care Med

Self Cite

113

View full text Add to dashboard Cite

Rationale:Cross-sectional studies demonstrate an association between metabolic syndrome and impaired lung function. Objectives: To define if metabolic syndrome biomarkers are risk factors for loss of lung function after irritant exposure. Methods: A nested case-control study of Fire Department of New York personnel with normal pre-September 11th FEV 1 and who presented for subspecialty pulmonary evaluation before March 10, 2008. We correlated metabolic syndrome biomarkers obtained within 6 months of World Trade Center dust exposure with subsequent FEV 1 . FEV 1 at subspecialty pulmonary evaluation within 6.5 years defined disease status; cases had FEV 1 less than lower limit of normal, whereas control subjects had FEV 1 greater than or equal to lower limit of normal. Measurements and Main Results: Clinical data and serum sampled at the first monitoring examination within 6 months of September 11, 2001, assessed body mass index, heart rate, serum glucose, triglycerides and high-density lipoprotein (HDL), leptin, pancreatic polypeptide, and amylin. Cases and control subjects had significant differences in HDL less than 40 mg/dl with triglycerides greater than or equal to 150 mg/dl, heart rate greater than or equal to 66 bpm, and leptin greater than or equal to 10,300 pg/ml. Each increased the odds of abnormal FEV 1 at pulmonary evaluation by more than twofold, whereas amylin greater than or equal to 116 pg/ml decreased the odds by 84%, in a multibiomarker model adjusting for age, race, body mass index, and World Trade Center arrival time. This model had a sensitivity of 41%, a specificity of 86%, and a receiver operating characteristic area under the curve of 0.77. Conclusions: Abnormal triglycerides and HDL and elevated heart rate and leptin are independent risk factors of greater susceptibility to lung function impairment after September 11, 2001, whereas elevated amylin is protective. Metabolic biomarkers are predictors of lung disease, and may be useful for assessing risk of impaired lung function in response to particulate inhalation.

show abstract

Section: Discussionmentioning

confidence: 99%

Metabolic Syndrome Biomarkers Predict Lung Function Impairment

Naveed

Weiden

Kwon

et al. 2012

Am J Respir Crit Care Med

Self Cite

113

View full text Add to dashboard Cite

show abstract

“…We have recently identifi ed moderate reductions of a 1 -antitrypsin as another risk factor for accelerated decline of lung function after WTC exposure. 26 The sensitivity of the model containing GM-CSF and MDC is low, so biomarkers defi ning other pathways to disease are likely undiscovered. Other pathways to disease need to be defi ned for serum biomarkers to be clinically useful in directing therapy designed to prevent airfl ow obstruction after irritant exposure.…”

Section: Discussionmentioning

confidence: 99%

Inflammatory Biomarkers Predict Airflow Obstruction After Exposure to World Trade Center Dust

Nolan

Naveed

Comfort

et al. 2012

Chest

Self Cite

View full text Add to dashboard Cite

“…The average age was 46 years and 40 years in MZ and MM individuals, respectively. After September 11, the MZ subjects exhibited a 110 mL annual decline in FEV1, compared to 25-50 mL in their MM counterparts [77]. MEHTA et al [78] also found that exposure to dust, vapour, gas and fumes was associated with a greater decline in lung function among 97 MZ when compared to 3546 MM individuals with the same level of exposure.…”

Section: Effects Of Environmental and Occupational Exposuresmentioning

confidence: 96%

COPD in individuals with the PiMZ alpha-1 antitrypsin genotype

Ashry

Strange

2017

Eur Respir Rev

View full text Add to dashboard Cite

Since the discovery of severe alpha-1 antitrypsin deficiency as a genetic risk factor for emphysema, there has been ongoing debate over whether individuals with intermediate deficiency with one protease inhibitor Z allele (PiMZ, or MZ) are at some risk for emphysema. This is important, because MZ individuals comprise 2-5% of the general population. In this review we summarise the evidence about the risks of the MZ population to develop emphysema or asthma. We discuss the different study designs that have tried to answer this question. The risk of emphysema is more pronounced in case-control than in population-based studies, perhaps due to inadequate power. Carefully designed family studies show an increased risk of emphysema in MZ smokers. This is supported by the rapid decline in lung function of MZ individuals when compared to the general population after massive environmental exposures. The risk of asthma in MZ subjects is less studied, and more literature is needed before firm conclusions can be made. Augmentation therapy in MZ individuals is not supported by any objective studies. MZ smokers are at increased risk for emphysema that is more pronounced when other environmental challenges are present.

show abstract

Accelerated Spirometric Decline in New York City Firefighters With α;1-Antitrypsin Deficiency

Cited by 45 publications

References 42 publications

Metabolic Syndrome Biomarkers Predict Lung Function Impairment

Metabolic Syndrome Biomarkers Predict Lung Function Impairment

Inflammatory Biomarkers Predict Airflow Obstruction After Exposure to World Trade Center Dust

COPD in individuals with the PiMZ alpha-1 antitrypsin genotype

Contact Info

Product

Resources

About