Accelerometry-Measured Physical Activity and Inflammation after Gestational Diabetes

Gingras, Véronique; Vigneault, Jessica; Weisnagel, S. John; Tchernof, André; Robitaille, Julie

doi:10.1249/mss.0b013e318285402b

Cited by 12 publications

(8 citation statements)

References 31 publications

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“…Leipold et al (2006) reported that the 5G allele of the PAI-1 gene is associated with normal glucose tolerance in pregnant women independent of maternal age or BMI and it is also related to low fasting glucose values in the oral glucose tolerance test [ 108 ]. Physical activities can lower cardiometabolic risk in women with previous GDM and PAI-1 levels, as well as the level of C-reactive protein, leptin and triglycerides [ 109 ].…”

Section: Role Of Pai-1 In the Female Reproduction Systemmentioning

confidence: 99%

Role of Plasminogen Activator Inhibitor Type 1 in Pathologies of Female Reproductive Diseases

Yao

Vattai

Zhang

et al. 2017

IJMS

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Normal pregnancy is a state of hypercoagulability with diminishing fibrinolytic activity, which is mainly caused by an increase of plasminogen activator inhibitor type 1 (PAI-1). PAI-1 is the main inhibitor of plasminogen activators, including tissue-type plasminogen activator (tPA) and urokinase-type plasminogen activator (uPA). In human placentas, PAI-1 is expressed in extravillous interstitial trophoblasts and vascular trophoblasts. During implantation and placentation, PAI-1 is responsible for inhibiting extra cellular matrix (ECM) degradation, thereby causing an inhibition of trophoblasts invasion. In the present study, we have reviewed the literature of various reproductive diseases where PAI-1 plays a role. PAI-1 levels are increased in patients with recurrent pregnancy losses (RPL), preeclampsia, intrauterine growth restriction (IUGR), gestational diabetes mellitus (GDM) in the previous pregnancy, endometriosis and polycystic ovary syndrome (PCOS). In general, an increased expression of PAI-1 in the blood is associated with an increased risk for infertility and a worse pregnancy outcome. GDM and PCOS are related to the genetic role of the 4G/5G polymorphism of PAI-1. This review provides an overview of the current knowledge of the role of PAI-1 in reproductive diseases. PAI-1 represents a promising monitoring biomarker for reproductive diseases and may be a treatment target in the near future.

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Section: Role Of Pai-1 In the Female Reproduction Systemmentioning

confidence: 99%

Role of Plasminogen Activator Inhibitor Type 1 in Pathologies of Female Reproductive Diseases

Yao

Vattai

Zhang

et al. 2017

IJMS

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“…To the best of our knowledge, this study is the first to investigate the association of the number of breaks taken during SB, measured objectively by a device, and serum lipid profiles in a healthy middle-aged female population. Previous studies have focused on PA and SB in child [ 26 , 27 ], youth [ 28 ] or adult populations with certain physiological states or illnesses [ 29 – 31 ] or adults with different types of professions [ 32 , 33 ].…”

Section: Discussionmentioning

confidence: 99%

Higher number of steps and breaks during sedentary behaviour are associated with better lipid profiles

et al. 2021

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Background Physical activity (PA) is known to be associated with lipid profiles and the risk of both cardiovascular diseases and cancer. The aim of this study was to evaluate the association of objectively measured PA, sedentary behaviour (SB), amount of breaks during SB and number of daily steps with serum lipids in a healthy, Finnish, middle-aged, female population. Methods The participants (571) were recruited at mammography screening, target group was women aged 50–60 years. A measurement of PA was done with accelerometer, blood lipid profile was assessed, and questionnaires of participants characteristics were sent to participants. Results The participants with the highest number of daily breaks during SB (≥ 41) had the highest mean concentration of HDL-cholesterol (high density lipoprotein cholesterol, HDL-c) (1.9 mmol/l, standard deviation (SD) 0.4) and the lowest mean concentration of triglycerides (1.0 mmol/l, SD 0.5). HDL-c level was 0.16 mmol/l higher (p < 0.001) in the group with 28–40.9 breaks/day and 0.25 mmol/l higher (p < 0.001) among participants with ≥41 breaks/day than in the group with the fewest breaks during SB (< 28). Those with the most daily steps (≥ 9100) had the highest mean HDL-c level (1.9 mmol/l). HDL-c level was 0.16 mmol/l higher (p < 0.001) among the participants with 5600–9099 steps/day and 0.26 mmol/l higher (p < 0.001) among participants with ≥9100 steps/day than those with the fewest steps (< 5600). The number of daily steps was inversely associated with the triglyceride concentration. From wake-time, participants spent 60% in SB, 18% standing, 14% in light PA, and 9% in moderate-to-vigorous PA (MVPA). PA was associated with serum total cholesterol (TC), HDL-c and triglyceride levels. The mean HDL-c level was the highest in the lowest quartile of SB and in the highest quartile of MVPA. Conclusions To our knowledge, this is the first study showing a high number of objectively measured breaks during SB is associated with a favourable effect on the level of serum lipids, which may later translate into cardiovascular health among middle-aged women. Trial registration This study was registered and approved by the Regional Ethics Committee of Tampere University Hospital in Finland (approval code R15137).

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“…In young women who had GDM about seven years prior to enrolment, soluble TNF α R2 and IL-6 levels were higher than those in young women without a history of GDM [ 25 ]. In another cross-sectional study of predictors of inflammatory markers in young women ~three years after pregnancy complicated by GDM, higher waist circumference was significantly associated with higher CRP, leptin, and resistin and negatively with adiponectin [ 26 ]. Although the majority of women (~70%) did not meet recommended weekly levels of physical activity, participation in physical activity lowered cardiometabolic risk in women with prior GDM.…”

Section: Discussionmentioning

confidence: 99%

Inflammatory Markers in Older Women with a History of Gestational Diabetes and the Effects of Weight Loss

Ryan

2018

Journal of Diabetes Research

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The purpose of this study was to compare systemic inflammation in older women with a history of gestational diabetes (GDM) who developed impaired glucose tolerance (IGT) or type 2 diabetes (T2DM) to that in those with normal glucose tolerance (NGT) and to determine, in these women, the effect of weight loss (WL) induced by diet and exercise training on systemic inflammation and adipokine levels. This was a longitudinal clinical investigation of overweight/obese (BMI: 32 ± 1 kg/m2) women (59 ± 1 years) with a GDM history (n = 19) who had normal glucose tolerance (NGT, n = 7) or IGT/T2DM (n = 12). Women completed 6 months of weight loss induced by diet and exercise and underwent VO2max, body composition, blood draw, glucose tolerance testing, and 2-hour hyperinsulinemic-euglycemic clamps (40 mU·m−2·min−1). Glucose utilization (M) was 42% higher in the NGT group (P < 0.05). CRP was two-fold higher in the IGT/T2DM group than that in the NGT group (P < 0.01). Adiponectin levels were 59% higher in the NGT group than those in the IGT/T2DM group (P < 0.01). IL-6sR was higher in the NGT group (P < 0.01). The women lost body weight, body fat, visceral fat, and subcutaneous abdominal fat (P < 0.001). Fasting glucose (P < 0.05), fasting insulin, glucose, and insulin AUC decreased (all P < 0.005) after the intervention. M increased by 21% (P < 0.05). CRP (−16%) and TNFR1 (−6%) tended to decrease, whereas TNFα, IL-6, SAA, and adiponectin did not change in the group. In conclusion, older women with a history of GDM who have developed IGT or T2DM have higher CRP and reduced adiponectin levels despite similar BMI and total and abdominal obesity to those with NGT. Six months WL induced by diet and exercise improves body composition and increases insulin sensitivity without a significant modification of inflammatory markers and adiponectin levels.

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Accelerometry-Measured Physical Activity and Inflammation after Gestational Diabetes

Abstract: These analyses suggest that in the years after delivery, longer time spent in MVPA practice is associated with a lower cardiometabolic risk only in women with prior GDM who do not have abdominal obesity.

Cited by 12 publications

References 31 publications

Role of Plasminogen Activator Inhibitor Type 1 in Pathologies of Female Reproductive Diseases

Role of Plasminogen Activator Inhibitor Type 1 in Pathologies of Female Reproductive Diseases

Higher number of steps and breaks during sedentary behaviour are associated with better lipid profiles

Inflammatory Markers in Older Women with a History of Gestational Diabetes and the Effects of Weight Loss

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