Acceptability and Preferences of Dry HR HPV Self-Sampling Mailed Kits Among Canadian Women: A Cross-Sectional Study

Ruel-Laliberté, Jessica; Marieve, Jacob-Wagner; Julie, Bestman-Smith; Josianne, Paré

doi:10.1016/j.jogc.2023.02.012

Cited by 4 publications

(2 citation statements)

References 25 publications

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“…Long distance from the access point at the HIV clinic and the CLP location is a significant barrier to HPV self-sampling. Our findings are like previous studies which have assessed distance as a blockage to HPV self-sampling among HIV-infected women [21,33,37,40,47,49,50]. Therefore, there is a need to improve the CLP program which would create demand for HPV self-sampling in preferred places for HPV self-sampling among HIV-infected women.…”

Section: Effectiveness Of the Clinic-based Compared To Home-based Hpv...supporting

confidence: 82%

The efficacy of the clinic-based HPV self-sampling approach among HIV- infected rural women in Uganda.

Nyabigambo,

Mayega,

Obuya

et al. 2023

Preprint

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Objective: The main objective of this study was to determine the effectiveness of the clinic-based HPV self-sampling approach at a rural HIV clinic in Uganda. Methods: A simple single-blind randomized controlled trial was used to estimate the efficacy of a clinic-based (intervention) compared to a home-based (control) HPV self-sampling approach among 150 HIV-infected women aged 25-49 years at the rural HIV clinic. The Health Promotion Model (HPM) guided the broad conceptualization. The participants were randomized to either clinic or home-based HPV self-sampling using a ratio of 1:1. The assignment was concealed and handed over to the midwife. The outcome was a continuation rate for HPV self-sampling at 6 months follow-up among participants tested for HPV. Survival analysis was used to determine the effectiveness of the clinic-based HPV self-sampling. The continuation rate was determined using the intention to treat analysis. The predictors of time to continue with HPV self-sampling in both arms, recovery, and Cox proportional hazards regression were used. The multivariable model was built using the forward modeling approach while controlling for confounding variables. The best model was selected after comparing the fitness of the final models (global test under chi-squared distribution). A Cox–Snell residual plot was fitted to ensure the final model did not violate the proportional hazards assumption. Adjusted Hazard ratios and their 95% confidence interval were reported. Results: The results show that of the HIV-infected women in the clinic-based arm, 92% (69/75) had attained at least a primary level education, 78.7% (59/75) were self-employed, and 74.4% (56/75) had a history of STIs compared to those in the home-based HPV self-sampling arm. The overall continuation rate was generally low at 30.7% (46/150) among HIV-infected women receiving HPV self-sampling in both arms. The continuation rate of HPV self-sampling was higher at 41.3% (31/75) among HIV-infected women randomized to receive clinic-based HPV self-sampling compared to the 20% (15/75) of those in the home-based arm. The average time for timely continuation of HPV self-sampling of 8.2 days while those in the home-based arm had 22 days. The factors that influenced the continuation of HPV self-sampling were residing between 6-10km (HR:0.11; CI: 0.014-0.84), a history of taking alcohol (HR: 7.74; CI: 1.06-56.54), age of a sexual debut above 18 years (HR:1.48; CI:1.08-2.03) and educated about HPV by the health worker (HR: 17:22; CI: 1.106-268.42). Conclusion: The overall continuation rate for HPV self-sampling is low. The clinic-based HPV self-sampling is more effective compared to the home-based HPV self-sampling approach. The factors influencing the increased continuation of HPV self-sampling are having a history of taking alcohol, age at sexual debut of >18 years, and receiving HPV education from health workers. Therefore, it is important to improve HPV self-sampling services at the HIV clinics and boost the capacity of health workers to educate HIV-infected women on HPV as well as provide integrated HPV self-sampling within the HIV clinics.

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Section: Effectiveness Of the Clinic-based Compared To Home-based Hpv...supporting

confidence: 82%

The efficacy of the clinic-based HPV self-sampling approach among HIV- infected rural women in Uganda.

Nyabigambo,

Mayega,

Obuya

et al. 2023

Preprint

View full text Add to dashboard Cite

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“…3 Self-sampling has been shown to increase participation in screening, be acceptable to participants, yield reliable results, and lead to reasonable attendance at colposcopy follow up. 3,17,18 To be able to perform reflex cytology as the guidelines recommend, if a vaginal self-sample tests positive for HPV, the next step is for a health care provider to collect a liquid-based cytology sample. Participants in the screening program should be aware that a pelvic exam may still be necessary based on the results of the test.…”

Section: Age and Interval Of Screening With Hpv Testingmentioning

confidence: 99%

2024 Updates to Cervical Cancer Screening in Canada

Reardon

2024

Can Womens Health Today

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The landscape of cervical cancer screening in Canada is about to undergo a major shift from cytology-based screening to testing directly for the presence of high-risk strains of the human papilloma virus (HPV), the persistence of which is known to be a prerequisite for the development of almost all cases of cervical cancer. In 2018, the World Health Organization declared a call to action for the worldwide elimination of cervical cancer by 2040. Subsequently the Canadian Partnership Against Cancer (CPAC) released an action plan outlining the necessary steps for Canada to reach this goal. One of the 3 major priorities identified in the action plan is the transition to primary HPV testing. This transition from screening to testing represents a major shift in infrastructure and also a shift in mindset for clinicians, policymakers, and the public. To help guide this transition, CPAC has collaborated with the Gynecologic Oncology Society of Canada (GOC) and the Society of Canadian Colposcopists (SCC) to release two open-access, evidence‑based guidelines in June 2023. These guidelines address how to manage a positive HPV screening test, and colposcopy in the context of primary HPV‑screening. This paper will outline the evolution of cervical cancer screening in Canada along with the rationale behind the transition to HPV testing. Also included is a discussion on the broad recommendations from the 2023 CPAC/GOC/SCC guidelines, as well as recommendations for age and interval of screening and special populations. Readers of this article in e-journal format can access the Canadian Guideline on the Management of a Positive Human Papillomavirus Test and Guidance for Specific Populations here. Readers may also access the 2023 Canadian Colposcopy Guideline: A Risk-Based Approach to Management and Surveillance of Cervical Dysplasia here.

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Comparison of diagnostic accuracy and acceptability of self-sampling devices for human Papillomavirus detection: A systematic review

Aimagambetova,

Atageldiyeva,

Marat

et al. 2024

Preventive Medicine Reports

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Acceptability and Preferences of Dry HR HPV Self-Sampling Mailed Kits Among Canadian Women: A Cross-Sectional Study

Cited by 4 publications

References 25 publications

The efficacy of the clinic-based HPV self-sampling approach among HIV- infected rural women in Uganda.

The efficacy of the clinic-based HPV self-sampling approach among HIV- infected rural women in Uganda.

2024 Updates to Cervical Cancer Screening in Canada

Comparison of diagnostic accuracy and acceptability of self-sampling devices for human Papillomavirus detection: A systematic review

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