Acceptability of two spermicides in five countries

Raymond, Elizabeth G.; Alvarado, Gloria; Ledesma, Lola; S, Diaz; Bassol, Susana; Morales, Edwin E.; Fernández, Víctor; Carlos, Gerardo

doi:10.1016/s0010-7824(99)00060-8

Cited by 21 publications

(13 citation statements)

References 5 publications

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“…Furthermore, the present analysis did not show any association between acceptability and time to pregnancy on an individual level. A similar result was noted in a previous randomized trial of two spermicides [2]. The interpretation of these findings is not straightforward, as the analysis was observational and we may not have been able to adjust for all of the relevant confounders of any possible association between acceptability and pregnancy.…”

Section: Discussionsupporting

confidence: 82%

“…In our population, acceptability was higher in older women, but no such association was found in a previous study of spermicides conducted largely in developing countries [2]. Notably, although our participants were specifically informed that the contraceptive efficacy of spermicides is poor compared to that of other methods, spermicide acceptability was unrelated to desire to avoid pregnancy or to coital frequency at admission, which is a risk factor for pregnancy.…”

Section: Discussioncontrasting

confidence: 54%

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Acceptability of five nonoxynol-9 spermicides

et al. 2005

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Objective-To examine the acceptability of five nonoxynol-9 (N-9) spermicides.Methods-We analyzed data from a randomized trial of five products, including three gels containing different amounts of N-9 per dose, a film and a suppository. In the trial, 1536 participants were asked to use the assigned spermicide for 7 months and to complete questionnaires 4 weeks after admission and at discontinuation.Results-Overall, 43% of participants liked their spermicide "very much." This proportion was higher in the three gel groups than in the suppository and film groups. Difficulty with insertion, messiness and discontent with timing of insertion were common complaints in all groups. After adjustment for selected baseline factors, acceptability on the first questionnaire was not related to duration or consistency of subsequent spermicide use or to subsequent time to pregnancy.Conclusions-In this study, all five spermicides were considered acceptable by most users. Acceptability did not appear to influence spermicide use or pregnancy risk.

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Section: Discussionsupporting

confidence: 82%

Section: Discussioncontrasting

confidence: 54%

Acceptability of five nonoxynol-9 spermicides

et al. 2005

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“…Indeed, in acceptability studies comparing vaginal contraceptive films to gels, films have performed well. 15,16 Secondly, because films are dissolved in physiologic fluids, they should not dilute the endogenous antibacterial and antiviral properties of vaginal fluid in the same manner as gel formulations, and hence should only minimally impact innate immunity. There are other potential advantages of films related to logistics and manufacturing.…”

Section: Introductionmentioning

confidence: 99%

A Phase 1 Trial to Assess the Safety, Acceptability, Pharmacokinetics, and Pharmacodynamics of a Novel Dapivirine Vaginal Film

Bunge

Dezzutti

Rohan

et al. 2016

JAIDS Journal of Acquired Immune Deficiency Syndromes

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Background Films may deliver antiretroviral drugs efficiently to mucosal tissues. In this first in-human trial of a vaginal film for delivering the non-nucleoside reverse transcriptase inhibitor dapivirine, safety, pharmacokinetics, and pharmacodynamics of film and gel formulations were compared to placebo. Methods 61 healthy HIV negative women were randomized to daily dapivirine (0.05%) or placebo gel, or dapivirine (1.25mg) or placebo film for seven days. The proportion of participants experiencing Grade 2 and higher adverse events related to study product were compared. Plasma dapivirine concentrations were quantified. Paired cervical and vaginal tissue biopsies obtained ∼2 hours following the last dose were measured for tissue drug concentration and exposed to HIV in an ex vivo challenge assay. Results Two Grade 2 related AEs occurred in the placebo film group. Women randomized to gel and film products had 4 log10 higher of dapivirine in cervical and vaginal tissues than plasma. While gel and film users had comparable plasma dapivirine concentrations, tissue concentrations of dapivirine were 3 to 5 times higher in the gel users when compared to film users. HIV replication in the ex vivo challenge assay was significantly reduced in vaginal tissues from women randomized to dapivirine film or gel; furthermore, tissue drug concentrations were highly correlated with HIV protection. Women rated the film more comfortable with less leakage, but found it more difficult to insert than gel. Discussion Both film and gel delivered dapivirine at concentrations sufficient to block HIV ex vivo. This proof of concept study suggests film formulations for microbicides merit further investigation.

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“…Los espermicidas son una buena opción como método anticonceptivo controlado por la mujer debido a que su uso es directamente dependiente del coito pero no lo hace dependiente de la cooperación del compañero sexual, además tienen un bajo costo, amplia disponibilidad, variabilidad, (McNaught & Jamieson, 2005;Raymond et al, 1999) y se hacen fáciles de usar sobre todo para aquellas mujeres que tienen relaciones sexuales esporádicas, no programadas y no desean utilizar métodos hormonales (Burke et al, 2010), los cuales generalmente requieren de un uso prolongado.…”

Section: Ventajas De Los Espermicidasunclassified

Espermicidas: Una alternativa de anticoncepción para considerar

Uribe-Clavijo

Ospina-Medina

Álvarez-Gomez

et al. 2012

TecnoL.

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El objetivo de éste artículo fue realizar una revisión bibliográfica que permitiera referir algunos datos históricos, generalidades, uso, ventajas y desventajas sobre los espermicidas. Mediante el uso de diferentes bases de datos biomédicas, utilizando los términos Anticoncepción, Espermato-zoide, Espermicidas, Nonoxinol-9, Microbicida y Productos naturales se realizó una revisión de la literatura y para esto, se seleccionaron diferen-tes artículos científicos, documentos y manuales que permitieron la reali-zación del presente manuscrito, encontrando que desde hace muchos años la anticoncepción ha sido un tema de gran interés en el mundo tratando aspectos como el control de la natalidad y algunas infecciones de transmi-sión sexual. Con el tiempo se han desarrollado métodos anticonceptivos, entre ellos los espermicidas de origen sintético, que cuentan con una multiplicidad de ventajas y desventajas. Sin embargo, diferentes organi-zaciones han planteado la necesidad de buscar nuevos compuestos activos con propiedades espermicidas y microbicidas, que presenten mínimos efectos secundarios; entre estos nuevos compuestos, se destacan en el presente artículo aquellos espermicidas derivados de productos naturales.

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Acceptability of two spermicides in five countries

Cited by 21 publications

References 5 publications

Acceptability of five nonoxynol-9 spermicides

Acceptability of five nonoxynol-9 spermicides

A Phase 1 Trial to Assess the Safety, Acceptability, Pharmacokinetics, and Pharmacodynamics of a Novel Dapivirine Vaginal Film

Espermicidas: Una alternativa de anticoncepción para considerar

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