Acceptance towards Monkeypox Vaccination: A Systematic Review and Meta-Analysis

Abstract

Vaccination it is considered a vital strategy in order to mitigate monkeypox by protecting from severe disease and helping in reduction of hospitalisations. In this sense, this study aims to estimate the global prevalence of vaccination acceptance against monkeypox. We conducted a systematic review with a comprehensive search strategy for the following databases: PubMed, Scopus and Web of Science. A random-effect model meta-analysis was carried out using observational studies assessing the intention of vaccines against monkeypox from multiple continents. The quality assessment was developed using the Newcastle-Ottawa Scale adapted for cross-sectional studies. In addition, a subgroup analysis by study location and population and a sensitivity analysis was developed.Eleven cross-sectional studies were included. A total of 8045 participants were included. The pooled prevalence of monkeypox vaccination acceptance in all participants was 56.0% (95%CI: 42.0–70.0%). In the subgroup analysis of monkeypox vaccine acceptance according to continents, the prevalence of vaccine acceptance was 50.0% (95%CI: 24.0–76.0%) in Asian countries and 70.0% (95%CI: 55.0–84.0%) in European countries. The prevalence of vaccine acceptance was 43.0% (95%CI: 35.0–50.0%) in the general population, 63.0% (95%CI: 42.0–70.0%) in healthcare workers, and 84.0% (95%CI: 83.0–86.0%) in the LGBTI community. Despite the high prevalence of monkeypox vaccination acceptance in the LGBTI community found in our study, vaccination acceptance from healthcare workers and the general population are lower. Governments could use these results for planning, developing or promoting vaccination strategies and public health policies focused on these populations.

Monkeypox Vaccine Acceptance among Ghanaians: A Call for Action

“…In this study, we found that collective reasonability was a significant determinant of MPOX vaccine acceptance. Similarly, Ulloque-Badaracco et al [ 34 ] reported that participants with high collective responsibility reported a significantly greater uptake of the COVID-19 vaccine (64.7 vs. 49.7%). Further evidence was proven in Hong Kong and the United Kingdom (UK).…”

“…The overall acceptance rate for the monkeypox vaccination was 56.0% (95% CI: 42.0–70.0%). In the general population, the prevalence of vaccine acceptance was 43.0% (95% CI: 35.0–50.0%), among healthcare professionals it was 63.0% (95% CI: 42.0–70.0%), and among lesbian, gay, bisexual, and transgender (LGBTI) people, it was 84.0% (95% CI: 83.0–86.0%) [ 34 ]. In fact, people’s perceptions regarding vaccination acceptance may be influenced by a variety of local, racial, religious, cultural, and other factors, as well as false information, as was evidently seen during the COVID-19 pandemic [ 14 , 15 ].…”

Facing Mpox (Former Monkeypox) in Latin America: The Example of Peru and Its Vulnerable Healthcare System

“…The example of Peru is similar to other affected countries in Latin America [7]. Due to the many shortcomings of the Peruvian health system, it is vulnerable to outbreaks and other public health threats and unable to respond adequately to them.…”

“…These quantities are deficient compared to the population to be vaccinated, even requiring priority according to risk. Likewise, conducting comprehensive vaccination campaigns with an informative approach is paramount, as vaccine acceptance in the general population is pretty low [ 7 ]. Due to the lack of vaccines, the most vulnerable groups should be prioritized, such as the LGBTI+ community.…”

“…Fourth, we encourage strengthening epidemiological surveillance systems to provide updated data. As well, due to the low acceptance of vaccination [ 7 ], it should be monitored. Fifth, governmental standardized guidelines should be promptly published and constantly updated.…”