Accident vasculaire cérébral

Bouleti, Claire; Mathivet, Thomas; Lapergue, Bertrand; Monnot, Catherine; Germain, Stéphane

doi:10.1051/medsci/20143006003

Cited by 4 publications

(3 citation statements)

References 24 publications

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“…Stroke is a real public health problem. Each year, around fifteen million people suffer from it worldwide, of which five million die and another five million suffer from permanent disabilities [1] [2]. In developing countries (PVD), they represent the second leading cause of death, behind cardiovascular diseases, ahead of infectious diseases, in particular pulmonary or diarrheal infections, tuberculosis, AIDS or malaria and more than 80% of the deaths caused by these affections concern these countries.…”

Section: Introductionmentioning

confidence: 99%

Epidemiological Aspects of Stroke in Young People at the Friendship University Hospital Center in Bangui in the Central African Republic

Yangatimbi¹,

Zobanga²,

Grégbia³

et al. 2020

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Introduction: Stroke is a major public health problem even more dramatic in young people. Goal of the study: To make our contribution to the knowledge of strokes of the young subject. Methodology: It was a retrospective study conducted over a period of 02 years (January 2017 to December 2018) including the files of patients aged 18 to 49 years hospitalized for any suspected case of stroke in the Department of Neurology of C between Hospitalier A Sino-Central African Friendship University (CHUSCA) from Bangui. Results: During the study, 225 cases of stroke were recorded, including 26 cases in young subjects, representing a hospital frequency of 11.5%. The average age was 42.5 years with extremes ranging from 24 to 49 years. The most represented age group was 45 and 49 with a sex ratio (M/F) of 1.36. The average age for men was 41.93 years compared to 39.27 years for women. Civil servants were in the majority in 50% of the cases. Alcohol was the main FDR (80.8%) followed by hypertension (61.5%) and tobacco (50%). The majority of patients (57.70%) were admitted to neurology after the first 24 hours. Ischemic stroke represented 73.08% compared to 26.92% of AVCH. The lethality was 20.08%. The sequelae were found in 69.20% of cases. Cardiac exploration had found 57.10% of LVH. Conclusion: This study confirms a high frequency of stroke in the young subject. The predominance of modifiable FRCVs requires the implementation of a specific strategy based on awareness, early detection and effective and adequate PEC.

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Section: Introductionmentioning

confidence: 99%

Epidemiological Aspects of Stroke in Young People at the Friendship University Hospital Center in Bangui in the Central African Republic

Yangatimbi¹,

Zobanga²,

Grégbia³

et al. 2020

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“…Les troubles thromboemboliques tels que les embolies pulmonaires, la thrombose veineuse profonde, les crises cardiaques et les Accidents Vasculaires Cérébraux (AVC) étaient les principales causes de morbidité et de mortalité dans les pays développés (Dickneite et al, 1995 ;Go et al, 2014), avant la pandémie liée au coronavirus . Les AVC constituent une cause importante de cette mortalité et la première cause d'handicap moteur dans le monde (Bouleti et al, 2014). En médecine clinique, les récupérations motrices sont incomplètes pour 2/3 des personnes et une assistance humaine est indispensable pour 25 à 30% d'entre-elles (Hendricks et al, 2002).…”

Section: Introductionunclassified

“…Les effets neuroprotecteurs et neurorégénérateurs ont été mis en évidence sur deux modèles expérimentaux de « cérébro-lésion », l'un ischémique et l'autre traumatique (Quintard, 2014). Ainsi, pour pallier aux limites de la médecine clinique face aux séquelles des AVC, aux nombreux effets secondaires liés l'utilisation d'anticoagulants et autres agents thrombolytiques (Leys et al, 2009 ;Bouleti et al, 2014), l'utilisation des préparations à base de plantes dans le traitement des Maladies cardiovasculaires est, de plus en plus, courante. L'activité thrombolytique, antithrombotique, antioxydante de plusieurs plantes a déjà été évaluée (Kee et al, 2008 ;Daud et al, 2013, Luna-Vázquez et al, 2013Tanelli et al, 2017).…”

Section: Introductionunclassified

Phytothérapie et prise en charge des séquelles des accidents vasculaires cérébraux en Côte d’Ivoire

Cherry¹,

Losséni²,

Alain³

et al. 2020

J.Anim.Plant Sci.

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Les Accidents Vasculaires Cérébraux (AVC) sont une urgence de santé publique. Le présent travail vise à évaluer, dans la pharmacopée ivoirienne, les connaissances des phytothérapeutes puis à identifier les préparations médicamenteuses utilisées dans le traitement des séquelles des AVC, à déterminer leurs caractéristiques ethnopharmacologiques, phytochimiques, leur potentiel antioxydant et leur toxicité pour une meilleure prise en charge des malades. Les résultats des enquêtes réalisées auprès de 20 phytothérapeutes du Programme National de Promotion de la Médecine Traditionnelle (PNPMT) ont montré que l’hypertension artérielle est la principale cause des AVC et l’hémiplégie, la séquelle majeure. Parmi les 36 préparations collectées, 10 parmi les extraits aqueux ont fait l’objet de tests. Les résultats indiquent la présence de polyphénols, de flavonoïdes, de tanins, de stérols et de saponosides dans toutes les préparations. Daoutra Fort et Daoutra 3 sont celles qui ont présenté les teneurs les plus élevées en polyphénols (173913,8 et 151456,9 µg EAG/g MS) et en flavonoïdes (77,13 %et 75,07 %). Les résultats indiquent également que Ballo (CI50 = 0,0280 mg/mL), Daoutra Fort (0,0409 mg/mL) et Daoutra 3 (0,0593 mg/mL) présentent d’importants potentiels antioxydants. Les tests de toxicité aigüe ont indiqué que, pour les préparations, la DL50 est supérieure à 5000 mg/kg de pc. Elles peuvent être considérées comme non toxiques par voie orale. ABSTRACT Stroke are a public health emergency. The present work aims to evaluate, in the Ivorian pharmacopoeia, the knowledge of phytotherapists then to identify the medicinal preparations used in the treatment of the sequelae of stroke, to determine their ethnopharmacological and phytochemical characteristics, their antioxidant potential and their toxicity for a better taking in charge of the sick. The results of surveys carried out with 20 phytotherapists from the National Program for the Promotion of Traditional Medicine (PNPMT) showed that high blood pressure is the main cause of stroke and hemiplegia, the major sequel. Of the 36 Piba et al., 2020 Journal of Animal & Plant Sciences (J.Anim.Plant Sci. ISSN 2071-7024) Vol.46 (2): 8197-8211 https://doi.org/10.35759/JAnmPlSci.v46-2.4 8198 preparations collected, 10 of the aqueous extracts were tested. The results indicate the presence of polyphenols, flavonoids, tannins, sterols and saponosides in all preparations. Daoutra Fort and Daoutra 3 are those which presented the highest contents of polyphenols (173,913.8 and 151,456.9 µg EAG / g DM) and of flavonoids (77.13% and 75.07%). The results also indicate that Ballo (IC50 = 0.0280 mg / mL), Daoutra Fort (0.0409 mg / mL) and Daoutra 3 (0.0593 mg / mL) exhibit significant antioxidant potential. Acute toxicity testing indicated that for preparations the DL50 is greater than 5000 mg / kg bw. They can be considered nontoxic by the oral route.

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The no-reflow phenomenon: State of the art

Bouleti

Mewton

Germain

2015

Archives of Cardiovascular Diseases

150

103

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Primary percutaneous coronary intervention (PCI) is the best available reperfusion strategy for acute ST-segment elevation myocardial infarction (STEMI), with nearly 95% of occluded coronary vessels being reopened in this setting. Despite re-establishing epicardial coronary vessel patency, primary PCI may fail to restore optimal myocardial reperfusion within the myocardial tissue, a failure at the microvascular level known as no-reflow (NR). NR has been reported to occur in up to 60% of STEMI patients with optimal coronary vessel reperfusion. When it does occur, it significantly attenuates the beneficial effect of reperfusion therapy, leading to poor outcomes. The pathophysiology of NR is complex and incompletely understood. Many phenomena are known to contribute to NR, including leukocyte infiltration, vasoconstriction, activation of inflammatory pathways and cellular oedema. Vascular damage and haemorrhage may also play important roles in the establishment of NR. In this review, we describe the pathophysiological mechanisms of NR and the tools available for diagnosing it. We also describe the microvasculature and the endothelial mechanisms involved in NR, which may provide relevant therapeutic targets for reducing NR and improving the prognosis for patients.

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Accident vasculaire cérébral

Cited by 4 publications

References 24 publications

Epidemiological Aspects of Stroke in Young People at the Friendship University Hospital Center in Bangui in the Central African Republic

Epidemiological Aspects of Stroke in Young People at the Friendship University Hospital Center in Bangui in the Central African Republic

Phytothérapie et prise en charge des séquelles des accidents vasculaires cérébraux en Côte d’Ivoire

The no-reflow phenomenon: State of the art

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