Accidental poisoning with Aconitum: Case report and review of the literature

Bonanno, Giuseppe; Ippolito, Mariachiara; Moscarelli, Alessandra; Misseri, Giovanni; Caradonna, Rosaria; Accurso, Giuseppe; Cortegiani, Andrea; Giarratano, Antonino

doi:10.1002/ccr3.2699

Cited by 23 publications

(18 citation statements)

References 17 publications

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“…The genus Aconitum (Ranunculaceae) contain alkaloid toxins, such as aconitine, which have been related to gastrointestinal, neurological, and cardiac toxicity. 4 Aconitine binds to the voltage sensitive sodium channel in its open state and delays repolarization by prolonging influx of sodium and membrane depolarization which promotes early afterdepolarization. There is also activation of the sodium-calcium exchanger resulting in transient inward current and development of delayed afterdepolarization.…”

Section: Discussionmentioning

confidence: 99%

Beyond the Pleasure Principle - Fatal Cardiac Arrhythmias After Ingestion of an Herbal Medication

Lakhdhir

Alauddin

Haq

et al. 2022

J Ayub Med Coll Abbottabad

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There is increasing popularity in the use of herbal medicine for different ailments as these natural products are considered safer than conventional medicines; however, their use in dosage exceeding prescribed limits can result in serious toxic side effects. We present a case of a 63-year-old male who presented with complaints of restlessness, nausea, vomiting and tingling sensation on his body and ECG evidence of bi-directional ventricular tachycardia. On interrogation, it was revealed that the patient had self-prepared and consumed large quantity of an herbal medication (containing toxic aconite roots) as therapy for erectile dysfunction resulting in a fatal outcome.

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Section: Discussionmentioning

confidence: 99%

Beyond the Pleasure Principle - Fatal Cardiac Arrhythmias After Ingestion of an Herbal Medication

Lakhdhir

Alauddin

Haq

et al. 2022

J Ayub Med Coll Abbottabad

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“…The half-life of Aconitine has been reported to be about 3 hours but intoxication symptoms may persist for 30 hours. 10 The onset of symptoms occurs rapidly, within 10 to 20 minutes. Skin paresthesia, followed by numbness and unexplained ventricular tachycardia, with the history of ingestion of herbal medications alerts clinicians to the possibility of aconite poisoning which are relevant with our case.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, mexiletine or procainamide may be used to manage tachyarrhythmias caused by aconite poisoning. 10,15…”

Section: Discussionmentioning

confidence: 99%

Aconite Poisoning: A Case Report

2022

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“…Most patients who died of aconite poisoning were due to the collapsed cardiac function, in those cases, the heart beating actions were disrupted irregularly or slowed down [52,74,75]. However, with suitable, accurate and on-time treatment, patients who suffered from aconite poisoning could usually be rescued and survived, with or without some consequences [76][77][78].…”

Section: Clinical Aspects Of the Toxicology Of Aconitummentioning

confidence: 99%

The toxicology and detoxification of Aconitum: traditional and modern views

2021

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Aconitum carmichaeli Debx.-derived herbal medicine has been used for anti-inflammation and anti-arrhythmia purpose for more than two thousand years. It is processed into Chuanwu (Radix Aconiti praeparata) and Fuzi (Radix Aconiti lateralis praeparata) in Traditional Chinese Medicine, which are two useful drugs but with toxic properties. There have been patients poisoned by accidental ingestion of Aconitum plants or misuse of the herbal drug, and this is of great concern to study in-depth. In this review, we provided the traditional and contemporary practice of using Aconitum herbs as medicine, from functions, processing methods to toxicity in ethnomedicine aspects to discuss the underlying connections of traditional and modern understanding on the toxicity of Aconitum plants. We summarized the functions and toxicology of the herbal drugs are analyzed from chemical and clinical aspects, with the help of traditional and modern knowledge of medicine. The medicinal doses and lethal doses determined by researches are summarized, and the usage and processing methods are updated and reviewed in the modern view. In addition, clinical management of poisoned cases using western medicine is discussed. This review provides insights and awareness of safety when using Aconitum-derived herbal medicine, and the application of modern scientific knowledge to optimize the detoxification processes. We suggest the possibility to renew the current standard processing method from the official Pharmacopoeia all over the world.

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Accidental poisoning with Aconitum: Case report and review of the literature

Abstract: Aconitine intoxication by ingestion of Aconitum roots can lead to ventricular tachycardia and cardiac arrest and provides an example of the potential effect of self‐medication. Educational campaigns should be implemented to contain acute intoxications caused by herbal‐derived products.

Cited by 23 publications

References 17 publications

Beyond the Pleasure Principle - Fatal Cardiac Arrhythmias After Ingestion of an Herbal Medication

Beyond the Pleasure Principle - Fatal Cardiac Arrhythmias After Ingestion of an Herbal Medication

Aconite Poisoning: A Case Report

The toxicology and detoxification of Aconitum: traditional and modern views

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