Accumulation of memory T cells from childhood to old age: Central and effector memory cells in CD4+ versus effector memory and terminally differentiated memory cells in CD8+ compartment

Saule, Pasquine; Trauet, Jacques; Dutriez, Virginie; Lekeux, Véronique; Dessaint, Jean-Paul; Labalette, Myriam

doi:10.1016/j.mad.2005.11.001

Cited by 316 publications

(303 citation statements)

References 42 publications

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“…Predominance of CCR7 þ cells within the CD4 þ population was also described in peripheral blood. 11, 21 We observed an acute GVHD rate similar to those usually observed with allo-SCT in patients comparable to ours. One approach to evaluating whether, and to what extent, CCR7 þ T cells can be effective at initiating acute GVHD in human patients is to analyze whether the absolute numbers or the proportion of these cells correlates with incidences of GVHD.…”

Section: Discussionsupporting

confidence: 89%

“…[18][19][20][21] Many studies have reported on CD3 þ T cells and their CD4 þ and CD8 þ subpopulations in bone marrow stem cell (BMSC) or granulocyte colony-stimulating factor (G-CSF)-mobilized peripheral blood stem cell (PBSC) allografts. However, to our knowledge, none has investigated the distribution of naive, T CM , T EM and T TD subsets.…”

Section: Introductionmentioning

confidence: 99%

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A high proportion of donor CD4+ T cells expressing the lymph node-homing chemokine receptor CCR7 increases incidence and severity of acute graft-versus-host disease in patients undergoing allogeneic stem cell transplantation for hematological malignancy

et al. 2006

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CC-chemokine receptor 7 (CCR7), a chemokine receptor required for transmigration into lymphoid organs, is only expressed by naive and central memory T cells. T cells with a capacity of homing into lymphoid organs can initiate acute graft-versus-host disease (GVHD) in mice and respond vigorously in vitro to alloantigens in humans, but their impact on clinical outcomes is unknown. We evaluated prospectively the distribution of naive, central memory and CCR7 neg memory T-cell subsets in 39 bone marrow and 23 granulocyte colonystimulating factor-mobilized peripheral blood stem cell allografts and investigated their impact on patient outcomes. Ranges of the relative proportions of CCR7 þ cells within CD4 þ and CD8 þ T-cell populations were broad, but did not differ between the two sources of allografts. By multivariate analysis, high percentage of donor-derived CD4 þ CCR7 þ T cells (473.5%) significantly correlated with incidence, earliness of onset and severity of acute GVHD, conferring the highest adjusted hazard ratio (HR ¼ 3.9; 95% confidence interval 1.4-10.8; P ¼ 0.008) without interfering in other clinical events, especially chronic GVHD and relapse. Determination of the percentage of CD4 þ CCR7 þ T cells in the graft provides a predictive indicator of acute GVHD. Partial depletion of this subset may reduce the risk of acute GVHD while preserving immunotherapeutic effects.

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Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

A high proportion of donor CD4+ T cells expressing the lymph node-homing chemokine receptor CCR7 increases incidence and severity of acute graft-versus-host disease in patients undergoing allogeneic stem cell transplantation for hematological malignancy

et al. 2006

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“…S 11 was present at a much higher frequency in the two 22-mo-old mice (24% and 17%) compared with the two 5-mo-old mice (7% and 9%) within the unstimulated samples (see SI Appendix, Fig. S31E), consistent with the increase of the memory pool with age in humans (16,18). In the two 7.5-mo-old mice S 11 accounted for 22% and 14% of all cells.…”

Section: Resultssupporting

confidence: 71%

Automatic Classification of Cellular Expression by Nonlinear Stochastic Embedding (ACCENSE)

Shekhar

Brodin

Davis

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

212

216

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Mass cytometry enables an unprecedented number of parameters to be measured in individual cells at a high throughput, but the large dimensionality of the resulting data severely limits approaches relying on manual "gating." Clustering cells based on phenotypic similarity comes at a loss of single-cell resolution and often the number of subpopulations is unknown a priori. Here we describe ACCENSE, a tool that combines nonlinear dimensionality reduction with density-based partitioning, and displays multivariate cellular phenotypes on a 2D plot. We apply ACCENSE to 35-parameter mass cytometry data from CD8 + T cells derived from specific pathogen-free and germ-free mice, and stratify cells into phenotypic subpopulations. Our results show significant heterogeneity within the known CD8 + T-cell subpopulations, and of particular note is that we find a large novel subpopulation in both specific pathogen-free and germ-free mice that has not been described previously. This subpopulation possesses a phenotypic signature that is distinct from conventional naive and memory subpopulations when analyzed by ACCENSE, but is not distinguishable on a biaxial plot of standard markers. We are able to automatically identify cellular subpopulations based on all proteins analyzed, thus aiding the full utilization of powerful new single-cell technologies such as mass cytometry.immunophenotyping | machine learning | class discovery | CyTOF | FACS

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“…During normal ageing the number of naïve T cells decreases while the number of memory T cells increases (Saule et al, 2006). There is an accompanying loss of functional capacity, cellular integrity, and diversity of both CD4 + and CD8 + T cell repertoires (Dewan et al, 2012;Haynes and Maue, 2009;Larbi et al, 2008;Weiskopf et al, 2009).…”

Section: Naïve and Memory T Cells In Agingmentioning

confidence: 99%

Nutrition, diet and immunosenescence

Maijó

Clements

Ivory

et al. 2014

Mechanisms of Ageing and Development

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Ageing is characterized by immunosenescence and the progressive decline in immunity in association with an increased frequency of infections and chronic disease. This complex process affects both the innate and adaptive immune systems with a progressive decline in most immune cell populations and defects in activation resulting in loss of function. Although host genetics and environmental factors, such as stress, exercise and diet can impact on the onset or course of immunosenescence, the mechanisms involved are largely unknown. This review focusses on identifying the most significant aspects of immunosenescence and on the evidence that nutritional intervention might delay this process, and consequently improve the quality of life of the elderly. We would like to thank the reviewers for their careful review of our manuscript, which has been revised accordingly. Below, we have provided a point-by-point reply to the issues raised: AbstractAgeing is characterized by immunosenescence and the progressive decline in immunity in association with an increased frequency of infections and chronic disease. This complex process affects both the innate and adaptive immune systems with a progressive decline in most immune cell populations and defects in activation resulting in loss of function. Although host genetics and environmental factors, such as stress, exercise and diet can impact on the onset or course of immunosenescence, the mechanisms involved are largely unknown. This review focusses on identifying the most significant aspects of immunosenescence and on the evidence that nutritional intervention might delay this process, and consequently improve the quality of life of the elderly.

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Accumulation of memory T cells from childhood to old age: Central and effector memory cells in CD4+ versus effector memory and terminally differentiated memory cells in CD8+ compartment

Cited by 316 publications

References 42 publications

A high proportion of donor CD4+ T cells expressing the lymph node-homing chemokine receptor CCR7 increases incidence and severity of acute graft-versus-host disease in patients undergoing allogeneic stem cell transplantation for hematological malignancy

A high proportion of donor CD4+ T cells expressing the lymph node-homing chemokine receptor CCR7 increases incidence and severity of acute graft-versus-host disease in patients undergoing allogeneic stem cell transplantation for hematological malignancy

Automatic Classification of Cellular Expression by Nonlinear Stochastic Embedding (ACCENSE)

Nutrition, diet and immunosenescence

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