Accuracy Evaluation of Circular RNA in Diagnosing Lung Cancer in a Chinese Population

Xiao, Zhihao; Chen, Xinglei; Lü, Xiaodan; Zhong, Xiaoyu; Ling, Yihui

doi:10.1155/2019/7485389

Cited by 9 publications

(6 citation statements)

References 23 publications

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“…Emerging studies have established an important role of circRNAs in cancer initiation and progression. In recent years, circRNAs have been recommended as novel diagnostic and prognostic biomarkers in several cancers (41), including colorectal cancer (21), hepatocellular cancer (42,43), gastric cancer(44), esophageal cancer (45), and lung cancer (6,46). Our study implicated a marked correlation between abnormal circRNAs expression levels with clinical, diagnostic and prognostic significance in osteosarcoma.…”

Section: Discussionmentioning

confidence: 55%

Diagnostic and Prognostic Significance of Dysregulated Expression of Circular RNAs in Osteosarcoma

Zhang

et al. 2021

Expert Review of Molecular Diagnostics

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Section: Discussionmentioning

confidence: 55%

Diagnostic and Prognostic Significance of Dysregulated Expression of Circular RNAs in Osteosarcoma

Zhang

et al. 2021

Expert Review of Molecular Diagnostics

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“…Emerging studies have established an important role of circRNAs in cancer initiation and progression. In recent years, circRNAs have been recommended as novel diagnostic and prognostic biomarkers in several cancers [44], including colorectal cancer [29], hepatocellular cancer [45,46], gastric cancer [47], esophageal cancer [48], and lung cancer [9,49]. Our study implicated a marked correlation between abnormal circRNAs expression levels with clinical, diagnostic and prognostic signi cance in osteosarcoma.…”

Section: Discussionmentioning

confidence: 51%

Diagnostic and Prognostic Significance of Dysregulated Expression of Circular RNAs in Osteosarcoma

Zhang

et al. 2020

Preprint

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Background CircRNAs have emerged as pivotal regulators in osteosarcoma tumorigenesis and progression, but their prognostic and diagnostic significance remain unclear. Herein, we aimed to perform an updated meta-analysis to explore the clinical, diagnostic and prognostic values of circRNAs in osteosarcoma. Methods Several databases, including PubMed, Web of Science, EMBASE, Scopus and Cochrane Library, were systematically searched up to April 10, 2020. Eligible studies regarding the relationship between circRNAs levels and clinicopathological, diagnostic and prognostic values in osteosarcoma patients were included in this study. Pooled odds ratios with corresponding 95% confidence intervals were used to measure clinical characteristics, while hazard ratios with 95% CIs were adopted to assess overall survival (OS) and disease-free survival (DFS). Results Overall, 26 relevant studies involving 1,652 patients with osteosarcoma were enrolled, with eighteen studies on clinicopathological parameters, ten on diagnosis and eighteen on prognosis. For clinical parameters, overexpression of oncogenic circRNAs was intimately correlated with larger tumor size (P < 0.00001), advanced Enneking stage (P < 0.00001), poor differentiation (P = 0.0001), and distant metastasis (DM) (P < 0.00001). In contrast, the downregulated circRNAs showed negative correlation with Enneking stage (P = 0.002) and DM (P < 0.0001). For the diagnostic values, the summary area under the curve of circRNA for the discriminative efficacy between osteosarcoma patients and non-cancer counterparts was estimated to be 0.86 (95% CI: 0.83–0.89), with a weighted sensitivity of 0.80 (95% CI: 0.74–0.84), specificity of 0.80 (95%: 0.75–0.84), and diagnostic odds ratio of 15.48 (10.85–22.10), respectively. For the prognostic significance, oncogenic circRNAs had poor OS (HR = 1.92, 95% CI: 1.68–2.19) and DFS (HR = 2.65, 95% CI: 2.02–3.49), while elevated expression of tumor-suppressor circRNAs were closely related to longer OS (HR = 0.44, 95% CI: 0.28–0.69). Conclusions Taken together, our study showed that aberrantly expressed circRNA signatures could serve as potential biomarkers in diagnosis and prognosis in patients with osteosarcoma.

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“…In recent years, circRNAs have been recommended as novel diagnostic and prognostic biomarkers in several cancers (41), including colorectal cancer (21), hepatocellular cancer (42,43), gastric cancer(44), esophageal cancer (45), and lung cancer (6,46). Our study implicated a marked correlation between abnormal circRNAs expression levels with clinical, diagnostic and prognostic significance in osteosarcoma.…”

Section: Discussionmentioning

confidence: 55%

Diagnostic and prognostic significance of dysregulated expression of circular RNAs in osteosarcoma

Zhang

et al. 2020

Preprint

View full text Add to dashboard Cite

Background Circular RNAs (circRNAs) have emerged as pivotal regulators in osteosarcoma tumorigenesis and progression, but their prognostic and diagnostic significance remain unclear. Herein, we aimed to perform an updated meta-analysis to explore the clinical, diagnostic and prognostic values of circRNAs in osteosarcoma. Methods Several databases, including PubMed, Web of Science, EMBASE, Scopus and Cochrane Library, were systematically searched up to Mar 10, 2020. Eligible studies regarding the relationship between circRNAs levels and clinicopathological, diagnostic and prognostic values in osteosarcoma patients were included in this study. Pooled odds ratios (ORs) with corresponding 95% confidence intervals (CIs) were used to measure clinical characteristics, while hazard ratios (HRs) with 95% CIs were adopted to assess overall survival (OS) and disease-free survival (DFS). Results Overall, 26 relevant studies involving 1,652 patients with osteosarcoma were enrolled, with eighteen studies on clinicopathological parameters, ten on diagnosis and eighteen on prognosis. For clinical parameters, overexpression of oncogenic circRNAs was intimately correlated with larger tumor size (P <0.00001), advanced Enneking stage (P <0.00001), poor differentiation (P =0.0001), and distant metastasis (DM) (P <0.00001). In contrast, the downregulated circRNAs showed negative correlation with Enneking stage (P=0.002) and DM (P<0.0001). For the diagnostic values, the summary area under the curve (AUC) of circRNA for the discriminative efficacy between osteosarcoma patients and non-cancer counterparts was estimated to be 0.86 (95% CI: 0.83-0.89), with a weighted sensitivity of 0.80 (95% CI: 0.74-0.84), specificity of 0.80 (95%: 0.75-0.84), and diagnostic odds ratio (DOR) of 15.48 (10.85-22.10), respectively. For the prognostic significance, oncogenic circRNAs had poor OS (HR=1.92, 95% CI: 1.68-2.19) and DFS (HR=2.65, 95% CI: 2.02-3.49), while elevated expression of tumor-suppressor circRNAs were closely related to longer OS (HR=0.44, 95% CI: 0.28-0.69). Conclusions Taken together, our study showed that aberrantly expressed circRNA signatures could serve as potential predictive indicators in diagnosis and prognosis in patients with osteosarcoma.

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Accuracy Evaluation of Circular RNA in Diagnosing Lung Cancer in a Chinese Population

Cited by 9 publications

References 23 publications

Diagnostic and Prognostic Significance of Dysregulated Expression of Circular RNAs in Osteosarcoma

Diagnostic and Prognostic Significance of Dysregulated Expression of Circular RNAs in Osteosarcoma

Diagnostic and Prognostic Significance of Dysregulated Expression of Circular RNAs in Osteosarcoma

Diagnostic and prognostic significance of dysregulated expression of circular RNAs in osteosarcoma

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