Accuracy, sensitivity and specificity of fine needle aspiration biopsy in salivary gland tumours: A retrospective study

Stramandinoli, Roberta-Targa; Sassi, Laurindo-Moacir; Pedruzzi, Paola-Andrea; Ramos, Gyl-Henrique; Oliveira, Benedito-V; Ogata, Daniel-Cury; Ioshii, Sergio-Ossamu

doi:10.4317/medoral.15.e32

Cited by 23 publications

(33 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The overall accuracy has been reported to be 82% to 94% in distinguishing benign from malignant lesions. FNAC also has a reported sensitivity of 65% to 85% and a specificity of 90% to 100% ( [3], [4], [5], [6]). Table 2 shows that the sensitivity, specificity and accuracy of FNA diagnosis of salivary glands obtained in this study is comparable with the data obtained in similar studies done previously.…”

Section: Results and Observationsmentioning

confidence: 99%

Fine Needle Aspiration Cytology of Salivary Gland Lesions and Its Diagnostic Pitfalls – A Tertiary Care Centre Experience From North East India

Roy¹,

Deka²,

Dutta³

2013

jemds

View full text Add to dashboard Cite

-INTRODUCTION:Fine needle aspiration cytology (FNAC) of salivary gland lesions has become very popular as a pre-operative diagnostic tool. However, in some instances the final histology of these lesions differs from the FNAC result. OBJECTIVE: To determine the diagnostic accuracy of FNAC in salivary gland lesions and identify the salivary gland FNA cases having discordant histological diagnosis so that most common diagnostic pitfalls can be avoided. MATERIAL AND METHODS: Sixty four salivary gland FNAC cases from January 2009 to December 2010 were retrospectively reviewed to identify the cytological characteristics that may have contributed to this discrepancy. Only 44 cases could be correlated histopathologically. RESULTS: Of the 64 cases analysed cytologically, 4 smears turned out to be unsatisfactory for evaluation, hence only rest 60 smears were evaluated. Out of the 32 cases which were given as cytologically benign, 28 were confirmed as benign on histology, while 04 cases turned out as malignant on histology. Of the 12 cases which were cytologically malignant, 2 turned out to be benign on histology. Taking histology as the "gold standard", the following data were obtained: specificity 92.8%, sensitivity 69.8%, diagnostic accuracy 84.5%, positive predictive value 83% and negative predictive value 83%. CONCLUSION: Despite inadequate samples obtained in some cases, FNAC should be done in the preoperative diagnosis of salivary gland lesions as it offers high diagnostic accuracy and specificity and an acceptable sensitivity.

show abstract

Section: Results and Observationsmentioning

confidence: 99%

Fine Needle Aspiration Cytology of Salivary Gland Lesions and Its Diagnostic Pitfalls – A Tertiary Care Centre Experience From North East India

Roy¹,

Deka²,

Dutta³

2013

jemds

View full text Add to dashboard Cite

show abstract

“…Additionally, the degree of differentiation of neoplastic cells can be determined, which may aid in the selection of the type of surgical intervention. However, in the management of salivary gland masses, the cytology results of FNAB should be interpreted along with the clinical findings and radiological investigations (2). When performed and analyzed by experienced hands, FNAB has the advantage of providing valuable diagnostic data in a relatively short period of time (6).…”

Section: Introductionmentioning

confidence: 99%

“…Salivary gland tumors account for 3-10% of head and neck tumors (1)(2)(3). Fine-needle aspiration biopsy (FNAB) of the salivary gland mass is considered as an important diagnostic tool, although some controversy exists (4,5).…”

Section: Introductionmentioning

confidence: 99%

Role of Fine-Needle Aspiration Biopsy in the Management of Salivary Gland Masses

Edızer¹,

Server²,

Yiğit³

et al. 2016

Turk Arch Otorhinolaryngol

View full text Add to dashboard Cite

Objective: Fine-needle aspiration biopsy (FNAB) is widely used in the management of salivary gland masses. Its main advantage is its ability to differentiate benign from malignant disease. In this study, we aimed to evaluate the diagnostic ability of FNAB in salivary gland masses. Methods:The records of patients who had undergone FNAB before parotidectomy or submandibular gland excision between 2005 and 2013 were retrospectively analyzed. FNAB results were classified as negative, positive, suspicious for malignancy, and non-diagnostic. Preoperative FNAB results were compared with definitive histopathological results. The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy of FNAB results were calculated.Results: A total of 285 patients were enrolled. Among them, 230 (80.7%) had parotid gland and 55 (19.3%) had submandibular gland masses. Following a definitive histopathological examination, the most common benign tumor was pleomorphic adenoma (52.6%), whereas malignant tumors were mucoepidermoid carcinoma (2%) and squamous cell carcinoma (2%). The sensitivity, specificity, PPV, NPV and accuracy of FNAB results were 76.9%, 95.4%, 75%, 95.9%, and 92.6%, respectively. The rate of a suspicious cytology was 5.2% (15 patients) and that of a non-diagnostic cytology was 8.8% (25 patients). Conclusion:FNAB is a safe and simple diagnostic tool for the diagnosis of salivary gland masses and has a relatively high sensitivity and specificity. It may provide valuable information for patient counselling and surgical planning. The major drawbacks include a lower sensitivity than specificity and a relatively high rate of non-diagnostic results.

show abstract

“…In the study by Al- Khafaji et al (1998), reported the sensitivity of 82%, a specificity of 86% and an overall diagnostic accuracy of 84%. In the study by Stramandinoli et al (2010) after comparing 79 cases of result of aspiration and pathological results, the sensitivity was reported 86.2%, specificity 87.7% and the diagnostic value 82.3%, positive predictive value 86.2% and negative predictive value 87.7%.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Value of Fine Needle Aspiration in Salivary Gland Tumors Compared with the Histopathological Results after Mass Excision

Ranjbari¹,

Rahim²,

Masoumi³

et al. 2015

International J. of Cancer Research

View full text Add to dashboard Cite

Fine Needle Aspiration (FNA) is a relatively painless, safe and inexpensive diagnostic method, which is a widely accepted for the diagnosis of salivary glands neoplastic and inflammatory lesions before surgery. The aim of this study was to evaluate the diagnostic value of FNA in the diagnosis of salivary gland tumors nature compared with the histopathological results after mass excision. This is a cross-sectional study, where since April 2009 to March 2012, all patients complaining about salivary gland tumors referred to the ear, nose and throat ward of Ahvaz Imam Khomeini hospital and undergone FNA and biopsy have been studied. Then, the results of FNA were compared with pathology results after mass excision, as well as the diagnostic accuracy of FNA was calculated. In this study, 160 patients were studied including 88 females (55%) and 72 males (45%). Most patients were in the age group of 31-40 years and lowest in patients aged over 80 years. The mean age of patients was 41.7±18.9 with a minimum 3 years and the maximum was 85 years old. The FNA sensitivity in salivary gland tumor to pathological findings after mass excision was calculated 92.3% and its characteristics 99%. The positive predictive value was 96% and negative predicted value 97.9%. As shown in this study, FNA sensitivity has a high specificity and diagnostic value in the detection of the salivary gland lesions. Given that it is an inexpensive, safe and reliable method, it is recommended to be used more widely.

show abstract

Accuracy, sensitivity and specificity of fine needle aspiration biopsy in salivary gland tumours: A retrospective study

Cited by 23 publications

References 20 publications

Fine Needle Aspiration Cytology of Salivary Gland Lesions and Its Diagnostic Pitfalls – A Tertiary Care Centre Experience From North East India

Fine Needle Aspiration Cytology of Salivary Gland Lesions and Its Diagnostic Pitfalls – A Tertiary Care Centre Experience From North East India

Role of Fine-Needle Aspiration Biopsy in the Management of Salivary Gland Masses

Diagnostic Value of Fine Needle Aspiration in Salivary Gland Tumors Compared with the Histopathological Results after Mass Excision

Contact Info

Product

Resources

About