Accurate modelling of small-scale linear ion trap operating mode using He buffer gas to improve sensitivity and resolution for in-the-field mass spectrometry

Abstract

Improved sensitivity and resolution of a small-scale linear ion trap is observed using He buffer.

Liquid-Phase Ion Trap for Ion Trapping, Transfer, and Sequential Ejection in Solutions

“…With a minimum ion-neutral damping effect in a vacuum environment, ions with different m/z ratios would possess different motional frequencies in the radio frequency (rf) quadrupole electric field. 12, 30,31 Supplemented with alternating current (AC) and direct current (DC) electric fields, ion trapping, 32,33 isolation, 25,30,34 dissociation, and sequential ejection 35−37 could be achieved in an ion trap. 38 However, the ruling principles of ion motion in solutions are totally different from those in a vacuum environment.…”

“…Indeed, great efforts have been carried out to fabricate and place miniaturized mass analyzers (ion traps or quadrupole rods) in aqueous solutions. − In MS, a quadrupole ion trap is an ion manipulation device operated in vacuum environments, − and it has been widely applied in physics to build an atomic clock and chemistry for molecular structure analysis. With a minimum ion-neutral damping effect in a vacuum environment, ions with different m / z ratios would possess different motional frequencies in the radio frequency (rf) quadrupole electric field. ,, Supplemented with alternating current (AC) and direct current (DC) electric fields, ion trapping, , isolation, ,, dissociation, and sequential ejection − could be achieved in an ion trap . However, the ruling principles of ion motion in solutions are totally different from those in a vacuum environment. , Due to strong viscous damping effects in solutions, ions usually no longer possess characteristic motional frequencies within a rf quadrupole electric field.…”