ACE gene I/D and NOS3 G894T polymorphisms and response to sildenafil in men with erectile dysfunction

Eisenhardt, Andreas; Sperling, H.; Hauck, Ekkehard W.; Porst, Hartmut; Stief, Christian G.; Rübben, H.; Müller, Norbert; Siffert, Winfried

doi:10.1016/s0090-4295(03)00137-7

Cited by 50 publications

(52 citation statements)

References 25 publications

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“…11,12 Thus, we aimed to investigate the possible association of eNOS gene intron 4 VNTR, E298A and IVF 23 þ 10 G/T polymorphisms in particular, with the responsiveness to sildenafil treatment in patients with ED. We hypothesized that ED patients with eNOS gene polymorphisms respond less to sildenafil.…”

Section: Introductionmentioning

confidence: 99%

The association between intron 4 VNTR, E298A and IVF 23+10 G/T polymorphisms of ecNOS gene and sildenafil responsiveness in patients with erectile dysfunction

et al. 2006

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Section: Introductionmentioning

confidence: 99%

The association between intron 4 VNTR, E298A and IVF 23+10 G/T polymorphisms of ecNOS gene and sildenafil responsiveness in patients with erectile dysfunction

et al. 2006

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“…They fo und that eNOS 894T al le le car ri ers had sig ni ficantly gre a ter fre qu en ci es of ED (80.0% vs 63.3%; p= 0.04) and lo wer II EF-5 sco res (13.2 (5.3) vs. 15.7 (6.1); p= 0.01) than G al le le car ri ers. In a study from Ger many, Ei sen hardt et al 9 in di ca ted that in di vidu als ho mozy go us for the 894T al le le of the eNOS G894T poly morp hism showed a re du ced res pon se to sil de na fil com pa red with in di vi du als ho mozy gous or he te rozy go us for the 894G al le le. In a Me xi can Mes ti zo po pu la ti on, Ro sas-Var gas et al 38 re por ted that the eNOS 894T al le le was as so ci a ted with an in cre a sed risk for ED.…”

Section: Discussionmentioning

confidence: 99%

“…In anot her study, Ma zo et al 36 fo und that, the pre va len ce of DD genoty pe in the ED gro up was sig ni fi cantly hig her than the non-ED gro up (p< 0.001). Anot her study in ves ti ga ting the sa me ge ne poly morp hism and ED was published by Ei sen hardt et al 9 This study enrol led 113 pa ti ents with ED and 108 con trols. The re sults sho wed that pa ti ents with ED ho mozy go us for the ACE I al le le had a bet ter drug res pon se to sil de na fil than did D al le le car ri ers.…”

Section: Discussionmentioning

confidence: 99%

“…8 NO is an im por tant va soac ti ve mo le cu le and a ne u rot rans mit ter es sen ti al for re la xa ti on of smo oth musc le cells of the cor pus ca ver no sum, and it has im por tant imp li ca ti ons for at he ro ge ne sis. 9 The ne u ro nal nit ric oxi de syntha se (nNOS) pro du ces NO in ca ver no us ner ves af ter parasy mpat he tic ac ti va ti on. 10 Azad zo i et al 11 sug gested that iNOS do mi na ted the erec ti le tis su e un der isc he mic/hypo xic con di ti ons, and in cre a sed iNOS le vels in vas cu lar tis su es might downre gu la te eNOS and thus in hi bit NO pro duc ti on and smo oth musc le re la xa ti on.…”

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Association of Angiotensin-Converting Enzyme I/D and eNOS G894T Gene Polymorphisms with Erectile Dysfunction

Cam¹,

Gümüş²,

Var³

et al. 2011

Turkiye Klinikleri J Med Sci

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432rectile dysfunction (ED) is defined as the inability to achieve and maintain an erection sufficient to permit satisfactory sexual intercourse, 1 and is a frequent chronic disorder increasing with age. In a community-based random sample observational study, 2 the total prevalen- Association of Angiotensin-ConvertingEnzyme I/D and eNOS G894T Gene Polymorphisms with Erectile Dysfunction A AB BS S T TR RA AC CT T O Ob b j je ec c t ti i v ve e: : Re cent stu di es sug gest that an gi o ten sin II and nit ric oxi de (NO) may mo du la te pe ni le smo oth musc le to ne and con trac ti lity. Be ca u se ge noty pes of the an gi o ten sin con ver ting enz yme (ACE) and en dot he li al nit ric oxi de syntha se (eNOS) poly morp hisms ha ve be en as so ci a ted with di sor ders in the vas cu lar system, in this study, we in ves ti ga ted an as so ci a ti on bet we en the ACE I/D and eNOS G894T ge ne poly morp hisms and erec ti le dysfunc ti on (ED). M Ma a t te e r ri i a al l a an nd d M Me et t --h ho od ds s: : A to tal of 44 pa ti ents and 45 con trol sub jects we re inc lu ded in the study. Di ag no sis of erec tile dysfunc ti on (< 26) was pro vi ded by In ter na ti o nal In dex of Erec ti le Func ti on (II EF). The ACE I/D ve eNOS G894T ge ne poly morp hisms we re ge noty ped using PCR and RFLP. R Re e s su ul lt ts s: : No sig ni fi cant ca se-con trol dif fe ren ce was ob ser ved for the ACE I/D and eNOS G894T ge ne poly morp hisms either by ge noty pe or al le le fre qu en ci es [(ACE I/D-X 2 = 0.930 p= 0.628) and eNOS 894 G/T-X 2 = 2.114 p = 0.348)]. In addition, the re was no sig ni fi cant dif fe ren ce bet we en ACE I/D (X 2 = 3.174 p= 0.787) and eNOS G894T (X 2 = 4.320 p= 0.633) and II EF sco res among the pa ti ent gro up. C Co on nc c l lu u s si i o on n: : In this study, no as so ci a ti on was fo und bet we en ACE I/D and eNOS G894T ge ne poly morp hisms and erecti le dysfunc ti on in the Tur kish po pu la ti on stu di ed.K Ke ey y W Wo or rd ds s: : Erec ti le dysfunc ti on; poly morp hism, angiotensin-converting enzyme Ö ÖZ ZE ET T A Am ma aç ç: : Ya pı lan ça lış ma lar da nit rik ok sit (NO) ve an ji yo ten sin II'nin pe nil düz kas la rın to nüs ve kon trak ti li te si ni et ki le ye bil di ği ile ri sü rül mek te dir. An ji yo ten sin dö nüş tü rü cü en zim (ACE-ADE) ve en do te li yal nit rik ok sit sen taz (eNOS) gen po li mor fizm le ri da mar has ta lık la rı ile iliş ki li ol duk ların dan, bu ça lış ma da, erek til dis fonk si yon ile eNOS 894 G/T (Glu298Asp) ve ACE I/D gen po li morfizm le ri ara sın da ki iliş ki nin in ce le me si amaç lan mış tır. G Ge er re eç ç v ve e Y Yö ön n t te em ml le er r: : Ça lış ma ya erek til dis fonk si yo nu (ED) olan 44 has ta ile 45 sağ lık lı kon trol gru bu alın dı. ED ta nı sı (< 26), Ulus la ra ra sı Erek til Fonk si yon İndek si ne (II EF) gö re de ğer len di ril di. Has ta ve kon trol gru bun da ACE I/D ve eNOS 894 G/T gen po li mor fizm le ri, po li me raz zin cir re ak si yo nu ve kı sıt la yı cı en zim ke si mi yön tem le ri ile sap tan dı. B ...

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“…28 Although no study of sildenafil response in relationship to the 894 polymorphism is available in a Mexican population, the sildenafil response was decreased in German ED patients heterozygous for Relationship satisfaction in men with ED E Zonana Farca et al the 894 T polymorphism, with a gene dosage effect evident in homozygous patients. 29 Interestingly, Mexican populations reportedly have lower CYP3A4 activity, the major enzyme in the liver responsible for sildenafil metabolism. 30,31 A comparison of sildenafil pharmacokinetics in young, healthy, Mexican men with historical pharmacokinetic data from Caucasian men taking the same 100 mg dose of sildenafil showed twofold higher peak levels of sildenafil in the serum of Mexican men, although the drug half-life of about 4 h was similar in both the groups.…”

Section: Discussionmentioning

confidence: 99%

Self-esteem, confidence and relationship satisfaction in men with erectile dysfunction: a randomized, parallel-group, double-blind, placebo-controlled study of sildenafil in Mexico

et al. 2008

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Erectile dysfunction (ED) negatively impacts self-esteem and relationship satisfaction. The Self-Esteem and Relationship (SEAR) questionnaire is a validated, ED-specific, patient-reported instrument that specifically addresses self-esteem and relationship issues within the context of ED. Effective ED treatment with sildenafil in a double-blind, placebo-controlled clinical trial conducted in Brazil, Mexico, Australia and Japan showed pooled cross-cultural improvements in self-esteem, confidence and relationship satisfaction. This report focuses on the results from the subgroup of men from nine Mexican centers who participated in the multinational study. A total of 95 men aged X18 years with clinically diagnosed ED and currently in a stable relationship were randomized to placebo (n ¼ 47) or sildenafil (n ¼ 48). The SEAR results for Mexican men showed that sildenafil treatment led to significant improvements in self-esteem, confidence and relationship satisfaction. These data support an earlier study showing that Latin American men taking sildenafil have similar safety and efficacy profiles compared to non-Latin counterparts.

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ACE gene I/D and NOS3 G894T polymorphisms and response to sildenafil in men with erectile dysfunction

Cited by 50 publications

References 25 publications

The association between intron 4 VNTR, E298A and IVF 23+10 G/T polymorphisms of ecNOS gene and sildenafil responsiveness in patients with erectile dysfunction

The association between intron 4 VNTR, E298A and IVF 23+10 G/T polymorphisms of ecNOS gene and sildenafil responsiveness in patients with erectile dysfunction

Association of Angiotensin-Converting Enzyme I/D and eNOS G894T Gene Polymorphisms with Erectile Dysfunction

Self-esteem, confidence and relationship satisfaction in men with erectile dysfunction: a randomized, parallel-group, double-blind, placebo-controlled study of sildenafil in Mexico

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