ACE inhibitors hypothesis generation for selective design, synthesis and biological evaluation of 3-mercapto-2-methyl-propanoyl-pyrrolidine-3-imine derivatives as antihypertensive agents

Docking, synthesis and bioassay studies of imine derivatives as potential inhibitors for dengue NS2B/ NS3 serine protease

“…In another example, Yang and his co-workers [10] reported imine to be a novel class of potential inducible nitric oxide synthase inhibitors. Imine derivatives have also been shown to be potential antihypertensive agents [11]. However, to the best of our knowledge, there have been no reports on imine derivatives with antiviral activities, in particular towards dengue virus.…”

Synthesis and preliminary biological screening of certain 5-aralkyl pyrrolidine-3-carboxylic acids as anticonvulsants

“…These compounds display a broad spectrum of pharmacodynamic and chemotherapeutic profiles [6]. Among these, are the compounds that display anticonvulsant activities [7][8][9][10][11][12][13][14][15].…”