Acellular dermal graft augmentation in quadriceps tendon rupture repair

Wilkins, Ross M.

doi:10.1097/bco.0b013e3181c7ea2e

Cited by 8 publications

(3 citation statements)

References 26 publications

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“…Specifically, human ADM has been reported to be used clinically for repair of rotator cuff tears (Wong et al 2010 ; Snyder and Bone 2007 ; Barber et al 2008 ; Burkhead et al 2007 ; Bond et al 2008 ; Dopirak et al 2007 ), during which the dermal matrix is typically used to augment a repair procedure in order to provide biomechanical strength as well as support directed healing. Also, Achilles and quadriceps tendon augmentation procedures using human ADM are reported with satisfying clinical outcomes (Wilkins 2010 ; Lee 2007 , 2008 ; Barber et al 2006 ). In addition, human ADM is commonly used for soft tissue reconstruction procedures including primary, staged, and revision breast reconstruction (Sbitany et al 2009 ; Nahabedian 2009 ; Salzberg 2006 ) and hernia repair (Kapfer and Keshen 2006 ; Albo et al 2006 ; Candage et al 2008 ; Mitchell and Cima 2011 ).…”

Section: Introductionmentioning

confidence: 99%

Decellularization of human dermis using non-denaturing anionic detergent and endonuclease: a review

et al. 2014

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Decellularized human dermis has been used for a number of clinical applications including wound healing, soft tissue reconstruction, and sports medicine procedures. A variety of methods exist to prepare this useful class of biomaterial. Here, we describe a decellularization technology (MatrACELL®) utilizing a non-denaturing anionic detergent, N-Lauroyl sarcosinate, and endonuclease, which was developed to remove potentially immunogenic material while retaining biomechanical properties. Effective decellularization was demonstrated by a residual DNA content of ≤4 ng/mg of wet weight which represented >97 % DNA removal compared to unprocessed dermis. Two millimeter thick MatrACELL processed human acellular dermal matrix (MH-ADM) exhibited average ultimate tensile load to failure of 635.4 ± 199.9 N and average suture retention strength of 134.9 ± 55.1 N. Using an in vivo mouse skin excisional model, MH-ADM was shown to be biocompatible and capable of supporting cellular and vascular in-growth. Finally, clinical studies of MH-ADM in variety of applications suggest it can be an appropriate scaffold for wound healing, soft tissue reconstruction, and soft tissue augmentation.

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Section: Introductionmentioning

confidence: 99%

Decellularization of human dermis using non-denaturing anionic detergent and endonuclease: a review

et al. 2014

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“…The other 2 Advances in Orthopedic Surgery major category of biological scaffold augment material is decellularized human skin allografts which made up slightly more than half of the augmented repair market in 2010 and this number is expected to increase [1] as surgeons choose allografts over both xenografts and nonaugmented repairs. Decellularized human skin allografts have been used for a variety of medical procedures, primarily wound healing, soft tissue reconstruction, and sports medicine applications [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24]. In theory, decellularization serves to remove potentially immunogenic material and also provides a clean scaffold for host cellular and vascular ingrowth [25].…”

Section: Introductionmentioning

confidence: 99%

A Simplified Approach for Arthroscopic Repair of Rotator Cuff Tear with Dermal Patch Augmentation

Levenda¹,

Sanders²

2015

Advances in Orthopedic Surgery

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Here, we describe an arthroscopic method specifically developed to augment rotator cuff repair using a flexible acellular dermal patch (ADP). In this method, an apparently complex technique is simplified by utilizing specific steps to augment a rotator cuff repair. In this method, using a revised arthroscopic technique, rotator cuff repair was performed. This technique allowed easy passage of the graft, excellent visualization, minimal soft tissue trauma, and full four-corner fixation of an ADP. Twelve patients underwent rotator cuff repair with augmentation using the combination of this method and ADP. Due to the technique and biomechanical characteristics of the material, the repairs have been stable and with high patient satisfaction.

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“…An alternative treatment for ruptured distal triceps tendon is a matrix scaffold for new tissue generation, an acellular human dermal matrix (ADM) allograft as reviewed by Wainwright and Bury [6]. Decellularized human skin has been used for a variety of medical procedures, primarily involving wound healing, soft tissue reconstruction, and sports medicine applications [7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Repair of distal triceps tendon rupture with human acellular dermal matrix (ADM)

Atzei¹,

Bertasi²

2016

Trauma Emerg Care

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Acellular dermal graft augmentation in quadriceps tendon rupture repair

Cited by 8 publications

References 26 publications

Decellularization of human dermis using non-denaturing anionic detergent and endonuclease: a review

Decellularization of human dermis using non-denaturing anionic detergent and endonuclease: a review

A Simplified Approach for Arthroscopic Repair of Rotator Cuff Tear with Dermal Patch Augmentation

Repair of distal triceps tendon rupture with human acellular dermal matrix (ADM)

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