Acellular dermal matrix in premature ejaculation

Zhang, Xiaowei; Wu, Yanyan; Zhang, Min; Yin, Huaqi; Li, Qing; Wei, Bai; Xu, Tao

doi:10.1097/md.0000000000013135

Cited by 11 publications

(17 citation statements)

References 30 publications

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“…Furthermore, the contribution to the above phenomena from penile and skin proprioceptive neurons should not be excluded. There are proprioception receptors in the penis and deeper layers of the skin [32][33][34]. Skin and bone nerves are involved in, or theorized to contribute to, the stretch reflex in accordance with Hilton's law [12,25,35].…”

Section: Repetitive Eccentric Contractions and Acute Compression Proprioceptive Axonopathymentioning

confidence: 99%

Post Orgasmic Illness Syndrome (POIS) and Delayed Onset Muscle Soreness (DOMS): Do They Have Anything in Common?

Sonkodi

Kopa

Nyírády

2021

Cells

133

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Post orgasmic illness syndrome is a rare, mysterious condition with an unknown pathomechanism and uncertain treatment. The symptoms of post orgasmic illness syndrome last about 2–7 days after an ejaculation. The current hypothesis proposes that the primary injury in post orgasmic illness syndrome is an acute compression proprioceptive axonopathy in the muscle spindle, as is suspected in delayed onset muscle soreness. The terminal arbor degeneration-like lesion of delayed onset muscle soreness is theorized to be an acute stress response energy-depleted dysfunctional mitochondria-induced impairment of Piezo2 channels and glutamate vesicular release. The recurring symptoms of post orgasmic illness syndrome after each ejaculation are suggested to be analogous to the repeated bout effect of delayed onset muscle soreness. However, there are differences in the pathomechanism, mostly attributed to the extent of secondary tissue damage and to the extent of spermidine depletion. The spermidine depletion-induced differences are as follows: modulation of the acute stress response, flu-like symptoms, opioid-like withdrawal and enhanced deregulation of the autonomic nervous system. The longitudinal dimension of delayed onset muscle soreness, in the form of post orgasmic illness syndrome and the repeated bout effect, have cognitive and memory consequences, since the primary injury is learning and memory-related.

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Section: Repetitive Eccentric Contractions and Acute Compression Proprioceptive Axonopathymentioning

confidence: 99%

Post Orgasmic Illness Syndrome (POIS) and Delayed Onset Muscle Soreness (DOMS): Do They Have Anything in Common?

Sonkodi

Kopa

Nyírády

2021

Cells

133

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“…81 , 84 One study followed 39 patients seeking treatment for ED, and after six months, flaccid girth increased >1 cm, erect girth by >2 cm and intravaginal ejaculatory latency time increased by 200 s on average. 84 …”

Section: Resultsmentioning

confidence: 99%

“… 84 Additionally, a thick ADM may affect proprioception receptors in the deep tissue and on the skin surface, leading to abnormal temperature and pressure differences. 84 …”

Section: Resultsmentioning

confidence: 99%

Clinical applications of acellular dermal matrices: A review

Petrie

Cox

Becker

2022

Scars, Burns & Healing

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Introduction The extracellular matrix (ECM) plays an integral role in wound healing. It provides both structure and growth factors that allow for the organised cell proliferation. Large or complex tissue defects may compromise host ECM, creating an environment that is unfavourable for the recovery of anatomical function and appearance. Acellular dermal matrices (ADMs) have been developed from a variety of sources, including human (HADM), porcine (PADM) and bovine (BADM), with multiple different processing protocols. The objective of this report is to provide an overview of current literature assessing the clinical utility of ADMs across a broad spectrum of applications. Methods PubMed, MEDLINE, EMBASE, Scopus, Cochrane and Web of Science were searched using keywords ‘acellular dermal matrix’, ‘acellular dermal matrices’ and brand names for commercially available ADMs. Our search was limited to English language articles published from 1999 to 2020 and focused on clinical data. Results A total of 2443 records underwent screening. After removing non-clinical studies and correspondence, 222 were assessed for eligibility. Of these, 170 were included in our synthesis of the literature. While the earliest ADMs were used in severe burn injuries, usage has expanded to a number of surgical subspecialties and procedures, including orthopaedic surgery (e.g. tendon and ligament reconstructions), otolaryngology, oral surgery (e.g. treating gingival recession), abdominal wall surgery (e.g. hernia repair), plastic surgery (e.g. breast reconstruction and penile augmentation), and chronic wounds (e.g. diabetic ulcers). Conclusion Our understanding of ADM’s clinical utility continues to evolve. More research is needed to determine which ADM has the best outcomes for each clinical scenario. Lay Summary Large or complex wounds present unique reconstructive and healing challenges. In normal healing, the extracellular matrix (ECM) provides both structural and growth factors that allow tissue to regenerate in an organised fashion to close the wound. In difficult or large soft-tissue defects, however, the ECM is often compromised. Acellular dermal matrix (ADM) products have been developed to mimic the benefits of host ECM, allowing for improved outcomes in a variety of clinical scenarios. This review summarises the current clinical evidence regarding commercially available ADMs in a wide variety of clinical contexts.

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“…To our knowledge, this is the first study on the application of MADM for the treatment of PE. Although some previous studies have used ADM patches to treat PE (Dai et al., 2019; Zhang et al., 2018), the MADM particles we used can better prevent tissue adhesion. Second, this surgical method is associated with less trauma and shorter postoperative recovery time than other surgical methods.…”

Section: Discussionmentioning

confidence: 99%

Application of micronised acellular dermal matrix for primary premature ejaculation: A preliminary study

Wang

et al. 2021

Andrologia

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This study aimed to explore the efficacy of injection of micronised acellular dermal matrix (MADM) particles for treating primary premature ejaculation. This study was a prospective single‐arm clinical trial. Thirty patients who met the surgical indications were enrolled. MADM particles, mixed in platelet‐rich plasma, were injected into Buck's fascia to spread over the dorsal penile nerve, suppress the influx of nerve impulses and, thus, reduce penis sensitivity. We evaluated the changes according to intravaginal ejaculation latency time using a stopwatch and a premature ejaculation diagnostic tool. Meanwhile, we also recorded sexual partner satisfaction and adverse events. All patients recovered well after surgery with no complications such as infections or allergies. The mean intravaginal ejaculation latency time before surgery was 0.72 ± 0.28 min, compared with 2.41 ± 0.54 min, 2.64 ± 0.41 min, 2.79 ± 0.25 min and 2.89 ± 0.35 min at, respectively, 4, 8, 16 and 20 weeks after surgery. The premature ejaculation diagnostic values and sexual partner satisfaction had significantly improved after treatment. Injection of MADM particles is an effective, safe and simple method for treating premature ejaculation.

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Acellular dermal matrix in premature ejaculation

Cited by 11 publications

References 30 publications

Post Orgasmic Illness Syndrome (POIS) and Delayed Onset Muscle Soreness (DOMS): Do They Have Anything in Common?

Post Orgasmic Illness Syndrome (POIS) and Delayed Onset Muscle Soreness (DOMS): Do They Have Anything in Common?

Clinical applications of acellular dermal matrices: A review

Application of micronised acellular dermal matrix for primary premature ejaculation: A preliminary study

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