Acetaldehyde inhibits angiotensin-converting enzyme activity of bovine lung

Thevananther, Sundararajah; Brecher, Arthur S.

doi:10.1016/0741-8329(93)90080-8

Cited by 21 publications

(14 citation statements)

References 22 publications

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“…Elevated AcH has been related to the kinin mechanisms, either by inhibiting the conversion of angiotensin I to II (Thevananther and Brecher, 1993), which attenuates the bradykinin degradation, or by the activation of plasma kallikrein (Hatake et al, 1990), which via kininogen activation increases the bradykinin formation (see also review by Ijiri, 1999). In addition to direct effects by AcH, or indirectly mediated by catecholamines (Adamson et al, 1969), the burst of bradykinin also may be linked to histamine effects, although this aspect is not yet evaluated.…”

Section: Acute Effects Of Alcohol Drinkingmentioning

confidence: 97%

The Role of Acetaldehyde in the Actions of Alcohol (Update 2000)

Eriksson

2001

Alcoholism Clin & Exp Res

228

116

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Background: Recent advances in the field of acetaldehyde (AcH) research have raised the need for a comprehensive review on the role of AcH in the actions of alcohol. This update is an attempt to summarize the available AcH research.Methods: The descriptive part of this article covers not only recent research but also the development of the field. Special emphasis is placed on mechanistic analyses, new hypotheses, and conclusions.Results: Elevated AcH during alcohol intoxication causes alcohol sensitivity, which involves vasodilation associated with increased skin temperature, subjective feelings of hotness and facial flushing, increased heart and respiration rate, lowered blood pressure, sensation of dry mouth or throat associated with bronchoconstriction and allergy reactions, nausea and headache, and also reinforcing reactions like euphoria. These effects seem to involve catecholamine, opiate peptide, prostaglandin, histamine, and/or kinin mechanisms. The contribution of AcH to the pathological consequences of chronic alcohol intake is well established for different forms of cancer in the digestive tract and the upper airways. AcH seems to play a role in the etiology of liver cirrhosis. AcH may have a role in other pathological developments, which include brain damage, cardiomyopathy, pancreatitis, and fetal alcohol syndrome. AcH creates both unpleasant aversive reactions that protect against excessive alcohol drinking and euphoric sensations that may reinforce alcohol drinking. The protective effect of AcH may be used in future treatments that involve gene therapy with or without liver transplantation.Conclusions: AcH plays a role in most of the actions of alcohol. The individual variability in these AcH-mediated actions will depend on the genetic polymorphism, not only for the alcohol and AcHmetabolizing enzymes but also for the target sites for AcH actions. The subtle balance between aversive and reinforcing, protecting and promoting factors will determine the overall behavioral and pathological developments.

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Section: Acute Effects Of Alcohol Drinkingmentioning

confidence: 97%

The Role of Acetaldehyde in the Actions of Alcohol (Update 2000)

Eriksson

2001

Alcoholism Clin & Exp Res

228

116

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“…Acetaldehyde-mediated inhibition of angiotensin-converting enzyme activity could be responsible for transient acute vasodilation and facial flushing in response to alcohol [37]. People who harbor the ALDH2 genetic polymorphism *1/*2 or *2/*2 refrain from excessive alcohol consumption because of the aversive reactions that result from increased acetaldehyde levels.…”

Section: Discussionmentioning

confidence: 99%

Associations between aldehyde dehydrogenase 2 (ALDH2) genetic polymorphisms, drinking status, and hypertension risk in Japanese adult male workers: a case–control study

Ota

Hisada

et al. 2015

Environ Health Prev Med

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Objectives We sought to identify associations between aldehyde dehydrogenase 2 (ALDH2), alcohol consumption, and hypertension in Japanese men. Methods The study participants were 1,225 male Japanese workers. We collected lifestyle information, body measurements, blood biochemical parameters, blood pressure measurements, and ALDH2 genotyping data during medical examinations conducted between March 2004 and January 2005 at a work facility and an affiliated company. Lifestyle data on alcohol intake and smoking were collected using self-administered questionnaires at the same time as when the aforementioned measurements were obtained. Results The genotype frequencies of ALDH2 genetic polymorphisms were 62.6, 32.7, and 4.7 % for

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“…Bradykinin is another well-known vasodilation factor (Fox et al, 1961;Guyton and Hall, 1996). Elevated AcH has been related to the kinin mechanisms, either by inhibiting the conversion of angiotensin I to II (Thevananther and Brecher, 1993), which attenuates the bradykinin degradation, or by the activation of plasma kallikrein (Hatake et al, 1990), which via kininogen activation increases the bradykinin formation (see also review by Ijiri, 1999). In addition to direct effects by AcH, or indirectly mediated by catecholamines (Adamson et al, 1969), the burst of bradykinin also may be linked to histamine effects, although this aspect is not yet evaluated.…”

Section: Acute Effects Of Alcohol Drinkingmentioning

confidence: 99%

The Role of Acetaldehyde in the Actions of Alcohol (Update 2000)

2001

Alcoholism: Clinical and Experimental Research

138

102

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AcH plays a role in most of the actions of alcohol. The individual variability in these AcH-mediated actions will depend on the genetic polymorphism, not only for the alcohol and AcH-metabolizing enzymes but also for the target sites for AcH actions. The subtle balance between aversive and reinforcing, protecting and promoting factors will determine the overall behavioral and pathological developments.

show abstract

Acetaldehyde inhibits angiotensin-converting enzyme activity of bovine lung

Cited by 21 publications

References 22 publications

The Role of Acetaldehyde in the Actions of Alcohol (Update 2000)

The Role of Acetaldehyde in the Actions of Alcohol (Update 2000)

Associations between aldehyde dehydrogenase 2 (ALDH2) genetic polymorphisms, drinking status, and hypertension risk in Japanese adult male workers: a case–control study

The Role of Acetaldehyde in the Actions of Alcohol (Update 2000)

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