Acetaminophen Use During Pregnancy: Effects on Risk for Congenital Abnormalities

Rebordosa, Cristina; Kogevinas, M; Horváth‐Puhó, Erzsébet; Nørgård, Bente Mertz; Morales, Maira Saad de Ávila; Czeizel, Andr̀ew E.; Vilstrup, Hendrik; Sørensen, H.T.; Olsen, Jørn

doi:10.1097/01.aoa.0000326392.65734.4f

Cited by 27 publications

(39 citation statements)

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“…Using two different rat models, we further support these data and show that fetal exposure to mild analgesics exerts an anti-androgenic action in the male. The cohort study was performed by trained paediatricians and incorporated mild cryptorchidism (high scrotal testis) as part of the continuum of maldescent, which is reflected in subtle primary testicular dysfunction (Suomi et al, 2006), setting this study significantly apart from former investigations that focused exclusively on the most severe types of cryptorchidism reported in Hospital registries (Norgard et al, 2005;Ofori et al, 2006;Rebordosa et al, 2008a). The results indicate an increase in prevalence after the maternal use of mild analgesic in both the mild and more severe forms of congenital cryptorchidism.…”

Section: Discussionmentioning

confidence: 99%

Intrauterine exposure to mild analgesics is a risk factor for development of male reproductive disorders in human and rat

et al. 2010

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Section: Discussionmentioning

confidence: 99%

Intrauterine exposure to mild analgesics is a risk factor for development of male reproductive disorders in human and rat

et al. 2010

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“…In the present study, 95.9z of the pregnant women were febrile at some point during treatment; however, their fever lasted for a lesser time than that of nonpregnant women, probably because of a more rapid initiation of treatment. In pregnant woman with influenza, prompt treatment of fever with acetaminophen is recommended to reduce the risks to the fetus (50).…”

Section: Discussionmentioning

confidence: 99%

Pandemic Influenza A (H1N1) Infection in Pregnant and Nonpregnant Women in Spain (2009–2010)

Suárez-Varela

Gónzález-Candelas

Astray³

et al. 2014

Jpn J Infect Dis

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SUMMARY:The present study aimed to compare the main features of infection with pandemic influenza A virus in pregnant and nonpregnant women admitted to hospitals in Spain during the first waves of the 2009-2010 influenza pandemic. This was a prospective (November 2009 to June 2010), multicenter observational study. All cases were women of reproductive age who had not been vaccinated against seasonal or pandemic influenza A. Influenza infection was confirmed by reverse transcriptionpolymerase chain reaction (RT-PCR). The sociodemographic and clinical data of all cases were reviewed. A total of 219 inpatients, including 49 pregnant women and 170 nonpregnant women, were enrolled in the study upon admission to participating hospitals. The most substantially different symptoms between the groups were respiratory distress and unilobar consolidation, both of which were more frequent among nonpregnant women. Antibiotics and systemic corticosteroids were more frequently used in nonpregnant women; however, there were no differences in the rates of treatment with antivirals. Our findings indicated that the compared with nonpregnant women, pregnant women in this study did not have significantly different symptoms and were not at increased risk of complications from pandemic influenza virus infection.

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“…A large Danish cohort study suggested an increase risk of preterm birth in mothers with pre-eclampsia (Rebordosa et al, 2009 Level III-3) following paracetamol exposure in early pregnancy; no increased prevalence of congenital anomalies (Rebordosa, Kogevinas, Horvath-Puho et al, 2008 Level III-3); but a slight increase in asthma in infants (Rebordosa, Kogevinas, Sorensen et al, 2008 Level III-3). A smaller study reported an increased risk of wheeze in offspring if exposure to paracetamol occurred in mid to late pregnancy (Persky et al, 2008 Level IV).…”

Section: Paracetamolmentioning

confidence: 99%

Acupuncture for analgesia in the emergency department: a multicentre, randomised, equivalence and non‐inferiority trial

Cohen

Smit

Andrianopoulos³

et al. 2017

Medical Journal of Australia

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Objectives: This study aimed to assess analgesia provided by acupuncture, alone or in combination with pharmacotherapy, to patients presenting to emergency departments with acute low back pain, migraine or ankle sprain. Design: A pragmatic, multicentre, randomised, assessor‐blinded, equivalence and non‐inferiority trial of analgesia, comparing acupuncture alone, acupuncture plus pharmacotherapy, and pharmacotherapy alone for alleviating pain in the emergency department. Setting, participants: Patients presenting to emergency departments in one of four tertiary hospitals in Melbourne with acute low back pain, migraine, or ankle sprain, and with a pain score on a 10‐point verbal numerical rating scale (VNRS) of at least 4. Main outcome measures: The primary outcome measure was pain at one hour (T1). Clinically relevant pain relief was defined as achieving a VNRS score below 4, and statistically relevant pain relief as a reduction in VNRS score of greater than 2 units. Results: 1964 patients were assessed between January 2010 and December 2011; 528 patients with acute low back pain (270 patients), migraine (92) or ankle sprain (166) were randomised to acupuncture alone (177 patients), acupuncture plus pharmacotherapy (178) or pharmacotherapy alone (173). Equivalence and non‐inferiority of treatment groups was found overall and for the low back pain and ankle sprain groups in both intention‐to‐treat and per protocol (PP) analyses, except in the PP equivalence testing of the ankle sprain group. 15.6% of patients had clinically relevant pain relief and 36.9% had statistically relevant pain relief at T1; there were no between‐group differences. Conclusion: The effectiveness of acupuncture in providing acute analgesia for patients with back pain and ankle sprain was comparable with that of pharmacotherapy. Acupuncture is a safe and acceptable form of analgesia, but none of the examined therapies provided optimal acute analgesia. More effective options are needed. Trial registration: Australian New Zealand Clinical Trials Registry, ACTRN12609000989246.

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Acetaminophen Use During Pregnancy: Effects on Risk for Congenital Abnormalities

Cited by 27 publications

References 0 publications

Intrauterine exposure to mild analgesics is a risk factor for development of male reproductive disorders in human and rat

Intrauterine exposure to mild analgesics is a risk factor for development of male reproductive disorders in human and rat

Pandemic Influenza A (H1N1) Infection in Pregnant and Nonpregnant Women in Spain (2009–2010)

Acupuncture for analgesia in the emergency department: a multicentre, randomised, equivalence and non‐inferiority trial

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Acetaminophen Use During Pregnancy: Effects on Risk for Congenital Abnormalities

Cited by 27 publications

References 0 publications

Intrauterine exposure to mild analgesics is a risk factor for development of male reproductive disorders in human and rat

Intrauterine exposure to mild analgesics is a risk factor for development of male reproductive disorders in human and rat

Pandemic Influenza A (H1N1) Infection in Pregnant and Nonpregnant Women in Spain (2009&ndash;2010)

Acupuncture for analgesia in the emergency department: a multicentre, randomised, equivalence and non‐inferiority trial

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Product

Resources

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Pandemic Influenza A (H1N1) Infection in Pregnant and Nonpregnant Women in Spain (2009–2010)