Acetone, ethanol and methanol extracts of Phyllanthus urinaria inhibit HSV-2 infection in vitro

Yang, Chien-Min; Cheng, Hua-Yew; Lin, Ta‐Chen; Chiang, Lien-Chai; Lin, Chun‐Ching

doi:10.1016/j.antiviral.2005.02.008

Cited by 67 publications

(57 citation statements)

References 20 publications

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“…Drug-resistant viral strains were increasingly isolated from patients, in particular immunocompromised individuals (20). Although more HSV inhibitors (both nucleoside and nonnucleoside analogues) were established, very few of them were approved for therapeutic use due to their relatively high toxicity (20). Thus, it is imperative to search for new antiherpetic agents that are less toxic and have lower probability of resistance development for the prevention or treatment of herpes virus infections.…”

Section: Treatments Of Herpes Simplex Virusmentioning

confidence: 99%

“…The only drawback of these limited anti-HSV drugs is the development of viral resistance against these treatments and drug toxicity (19)(20)(21). Drug-resistant viral strains were increasingly isolated from patients, in particular immunocompromised individuals (20). Although more HSV inhibitors (both nucleoside and nonnucleoside analogues) were established, very few of them were approved for therapeutic use due to their relatively high toxicity (20).…”

Section: Treatments Of Herpes Simplex Virusmentioning

confidence: 99%

Section: Treatments Of Herpes Simplex Virusmentioning

confidence: 99%

“…Herpesviridae family consists of at least eight species of single large double stranded DNA enveloped viruses that are pathogenic to humans (16)(17)(18)(19)(20). Among these species, HSV-1 and HSV-2 are more intriguing due to the enormous clinical symptoms that they may manifest, ranging from gingivostomatitis to keratoconjunctivitis, genital disease, encephalitis.…”

Section: Introduction On Hsvmentioning

confidence: 99%

“…Among these species, HSV-1 and HSV-2 are more intriguing due to the enormous clinical symptoms that they may manifest, ranging from gingivostomatitis to keratoconjunctivitis, genital disease, encephalitis. In addition, these viruses are likely to infect newborn and immunocompromised patients, which is more alarming (20). The main concern however, are their ability to remain latent and produce lifelong infections, get reactivated whenever triggered by a particular stimuli; which can include sunlight, stress or due to the weakened immunity, resulting in secondary infections (21).…”

Section: Introduction On Hsvmentioning

confidence: 99%

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Phyllanthus Sp a Local Plant With Multiple Medicinal Properties

Sd¹,

Yq²,

Sh³

2014

JUMMEC

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The plants of the genus Phyllanthus (Euphorbiaceae) are distributed in most tropical and subtropical regions of world. This plant has been long used as a traditional medicine to treat problems such as stomach, intestinal infections, kidney and urinary bladder disturbances, diabetes, and hepatitis B. There has been considerable interest in these plants in recent years. This review discusses the antiviral and anticancer aspects of Phyllanthus species. Scientific studies have demonstrated that extracts and purified isolated compounds (flavonoids, lignans, phenols, and terpenes) obtained from these plants possess antiviral effects against herpes simplex (HSV) and dengue virus infections (DENV). These observations are associated with the disruption of essential proteins needed during viral cycle, thus halting the viral replication. In addition, the Phyllanthus species have also been shown to exert inhibitory effects against selected cancers types. In these studies anti-proliferative, anti-metastatic, anti-angiogenic effects and induced apoptosis of human cancers cell lines were observed. These may be explained by the disruption of multiple survival pathways and differential protein expression. CONLCUSION:As a conclusion, tThe Phyllanthus plant possesses multiple medicinal properties, including antiviral and anticancer activities which may potentially be used as a medicinal source for many disease locally.

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Section: Treatments Of Herpes Simplex Virusmentioning

confidence: 99%

Section: Treatments Of Herpes Simplex Virusmentioning

confidence: 99%

Section: Treatments Of Herpes Simplex Virusmentioning

confidence: 99%

Section: Introduction On Hsvmentioning

confidence: 99%

Section: Introduction On Hsvmentioning

confidence: 99%

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Phyllanthus Sp a Local Plant With Multiple Medicinal Properties

Sd¹,

Yq²,

Sh³

2014

JUMMEC

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Phenolic Antioxidants from the Whole Plant of Phyllanthus urinaria

Zha

Qin

et al. 2007

Chemistry & Biodiversity

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The 1,1-diphenyl-2-picrydydrazyl (DPPH) assay on the extract of Phyllanthus urinaria L. (Euphorbiaceae) displayed considerable radical-scavenging activity (SC50 = 14.3 microg/ml). Further bioassay-guided purification of the extract led to the isolation of a series of 15 phenolic compounds, including the ellagitannins 1-7, the flavonoids 8-10, and the simple hydroxylated (or glycosylated) aromatic acids 11-15. Their structures were identified by spectroscopic analyses and comparison with authentic samples or literature data. The structure of repandinin B (1) was for the first time fully assigned by 1D- and 2D-NMR experiments. The phenolic compounds 1, 3, 4, 6, 9, 11, and 15 have not been isolated before from the title plant. The antioxidant activities and mushroom-tyrosinase-inhibitory activities of all compounds were determined by DPPH-radical-scavenging and mushroom-tyrosinase-inhibitory assays (Table 2).

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Chemical Constituents of the Plants from the Genus Phyllanthus

Liu

Gao

2014

Chemistry & Biodiversity

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Acetone, ethanol and methanol extracts of Phyllanthus urinaria inhibit HSV-2 infection in vitro

Cited by 67 publications

References 20 publications

Phyllanthus Sp a Local Plant With Multiple Medicinal Properties

Phyllanthus Sp a Local Plant With Multiple Medicinal Properties

Phenolic Antioxidants from the Whole Plant of Phyllanthus urinaria

Chemical Constituents of the Plants from the Genus Phyllanthus

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