Acetophenone derivatives from the roots of Melicope ptelefolia

Xu, Qi-Qi; Chen, Xinlin; Xu, Jinfang; Wang, Sibei; Luo, Jian‐Guang; Kong, Ling–Yi

doi:10.1016/j.fitote.2018.11.013

Cited by 8 publications

(1 citation statement)

References 22 publications

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“…Moreover, enhanced research is needed to conserve the species and to obtain new sources for further natural product discovery. Acetophenones and chromenes have been discovered in 14 species of Melicope [11,[14][15][16][17]27,[51][52][53][54][55][56][57][58] as well as in some species of its close relatives Acronychia and Medicosma [33,46,[59][60][61][62][63][64]. Due to the great variability of the acetophenones and chromenes in these genera, they may be of interest as biomarkers for chemotaxonomy.…”

Section: Resultsmentioning

confidence: 99%

New Acetophenones and Chromenes from the Leaves of Melicope barbigera A. Gray

Bandolik

Kassack

et al. 2021

Molecules

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The dichloromethane extract from leaves of Melicope barbigera (Rutaceae), endemic to the Hawaiian island of Kaua’i, yielded four new and three previously known acetophenones and 2H-chromenes, all found for the first time in M. barbigera. The structures of the new compounds obtained from the dichloromethane extract after purification by chromatographic methods were unambiguously elucidated by spectroscopic analyses including 1D/2D NMR spectroscopy and HRESIMS. The absolute configuration was determined by modified Mosher’s method. Compounds 2, 4 and the mixture of 6 and 7 exhibited moderate cytotoxic activities against the human ovarian cancer cell line A2780 with IC50 values of 30.0 and 75.7 µM for 2 and 4, respectively, in a nuclear shrinkage cytotoxicity assay.

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Section: Resultsmentioning

confidence: 99%

New Acetophenones and Chromenes from the Leaves of Melicope barbigera A. Gray

Bandolik

Kassack

et al. 2021

Molecules

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Natural-derived acetophenones: chemistry and pharmacological activities

Ahmadpourmir,

Attar,

Asili

et al. 2024

Nat. Prod. Bioprospect.

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Acetophenones are naturally occurring phenolic compounds which have found in over 24 plant families and also fungi strains. They are exist in both free or glycosides form in nature. The biological activities of these compounds have been assayed and reported including cytotoxicity, antimicrobial, antimalarial, antioxidant and antityrosinase activities. Herein, we review the chemistry and biological activity of natural acetophenone derivatives that have been isolated and identified until January 2024. Taken together, it was reported 252 acetophenone derivatives in which the genera Melicope (69) and Acronychia (44) were the principal species as producers of acetophenones. Graphical Abstract

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