Acetyl carnitine modified liposomes elevate cisplatin uptake in macrophage and cancer cells

Zahednezhad, Fahimeh; Zakeri–Milani, Parvin; Mojarrad, Javid Shahbazi; Sarfraz, Muhammad; Mahmoudian, M.R.; Baradaran, Behzad; Valizadeh, Hadi

doi:10.1016/j.jddst.2023.104198

Cited by 3 publications

(3 citation statements)

References 51 publications

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“…Recent studies have also shown the outstanding drug-carrying capabilities of liposomes. Zahednezhad et al [101] employed different techniques to formulate liposomal cisplatin (CDDP) delivery systems, achieving an embedding rate of 84.0-88.2%. Chen et al [10b] used antibody-modified liposomes to deliver clove essential oil to prolong its antimicrobial effect, which achieved the oil encapsulation, casein mosaicking and antibody coupling efficiencies of 16.9%, 70.1%, and 87.5%, respectively.…”

Section: Drug-carrying Liposomementioning

confidence: 99%

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Construction Strategy of Functionalized Liposomes and Multidimensional Application

Wang,

Lan,

Zhu

et al. 2024

Small

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Liposomes are widely used in the biological field due to their good biocompatibility and surface modification properties. With the development of biochemistry and material science, many liposome structures and their surface functional components have been modified and optimized one by one, pushing the liposome platform from traditional to functionalized and intelligent, which will better satisfy and expand the needs of scientific research. However, a main limiting factor effecting the efficiency of liposomes is the complicated environmental conditions in the living body. Currently, in order to overcome the above problem, functionalized liposomes have become a very promising strategy. In this paper, binding strategies of liposomes with four main functional elements, namely nucleic acids, antibodies, peptides, and stimuli‐responsive motif have been summarized for the first time. In addition, based on the construction characteristics of functionalized liposomes, such as drug‐carrying, targeting, long‐circulating, and stimulus‐responsive properties, a comprehensive overview of their features and respective research progress are presented. Finally, the paper critically presents the limitations of these functionalized liposomes in the current applications and also prospectively suggests the future development directions, aiming to accelerate realization of their industrialization.

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Section: Drug-carrying Liposomementioning

confidence: 99%

“…Zahednezhad et al. [ 101 ] employed different techniques to formulate liposomal cisplatin (CDDP) delivery systems, achieving an embedding rate of 84.0‐88.2%. Chen et al.…”

Section: Types and Applications Of Functionalized Liposomesmentioning

confidence: 99%

Construction Strategy of Functionalized Liposomes and Multidimensional Application

Wang,

Lan,

Zhu

et al. 2024

Small

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“…Regarding their structure, liposomes are colloidal systems formed by the self-assembly of amphiphilic lipid molecules in solution; their polar head and long-chain hydrocarbon tail provide a unique configuration that is capable of encapsulating both hydrophilic and lipophilic molecules [7]. Because of this, they have found applications, for example, as antitumor [8,9] and anti-ischemic stroke neuroprotective [10] agents, in the management of psoriasis [11], as vaccines to combat COVID-19 [6], and also as an approach to improve quercetin delivery to the skin [12].…”

Section: Introductionmentioning

confidence: 99%

Production and Properties of Quercetin-Loaded Liposomes and Their Influence on the Properties of Galactomannan-Based Films

et al. 2023

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The objective of this work was to prepare different concentrations of liposomes based on lecithin containing quercetin, and evaluate their effect on the properties of galactomannan films obtained from Cassia grandis seeds. Quercetin-loaded lecithin liposomes (QT-LL) were obtained by the ethanol injection method by incorporating quercetin in different concentrations in a previously prepared suspension of lecithin liposomes in water. Following characterization of QT-LLs by zeta potential and dynamic light scattering, QT-LL with 75 µg quercetin/mL suspension was incorporated at different concentrations in galactomannan films. The films obtained were characterized for color, solubility, moisture content (MC), water vapor permeability (WVP), scanning electron microscopy (SEM), X-ray diffraction (XRD), and Fourier-transform infrared (FTIR) spectroscopy. The size of lecithin liposomes with no quercetin was statistically than those containing quercetin above 50 µg/mL. All the QT-LLs presented a low polydispersity index, even considering their significant differences and similar values for zeta potential. The films displayed a rough surface and the galactomannan structure was confirmed by FTIR. Additionally, the amorphous nature of the polysaccharide was observed by XRD. The films were luminous, with a predominant yellow tendency and low opacity. The incorporation of QT-LL in galactomannan films did not lead to statistical differences for solubility and MC, while significant differences were observed for WVP. Galactomannan films were shown to be a promising structure for the incorporation of lecithin liposomes loaded with quercetin, pointing at promising applications for different applications.

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Platinum-based chemotherapy: trends in organic nanodelivery systems

Santos,

Silva,

Marques

et al. 2024

Nanoscale

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Acetyl carnitine modified liposomes elevate cisplatin uptake in macrophage and cancer cells

Cited by 3 publications

References 51 publications

Construction Strategy of Functionalized Liposomes and Multidimensional Application

Construction Strategy of Functionalized Liposomes and Multidimensional Application

Production and Properties of Quercetin-Loaded Liposomes and Their Influence on the Properties of Galactomannan-Based Films

Platinum-based chemotherapy: trends in organic nanodelivery systems

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