Acetyl salicylic acid augments functional recovery following sciatic nerve crush in mice

Subbanna, Prasanna Kumar T; Prasanna, C. G.; Gunale, Bhagawat K; Tyagi, Manoj

doi:10.1186/1749-7221-2-3

Cited by 21 publications

(15 citation statements)

References 9 publications

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“…In addition to reducing inflammatory reactions, reducing scar tissue is also one of the important aims in nerve healing. To achieve this goal, usage of steroids and nonsteroid anti-inflammatory drugs is beneficial [17] .…”

Section: Discussionmentioning

confidence: 99%

The Effects of Methylprednisolone and Vitamin A on the Healing of Traumatic Peripheral Nerve Paralysis

Sevük¹,

Vayısoğlu²,

Korlu³

et al. 2015

Int Adv Otol

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OBJECTIVE:This study planned to evaluate the effects of vitamin A (VA) and steroid treatment on nerve healing. Study design: we investigated electrophysiological, electron microscopic (EM), immunohistochemical, and biochemical findings in rat sciatic nerve model. MATERIALS and METHODS:In total, 112 female rats were divided into 16 groups, each consisting of 7 animals. Subjects were evaluated according to compound muscle action potential (CMAP) findings, ultrastructural staging of myelinated axons with EM, nitric oxide (NO) and malondialdehyde (MDA) findings in serum and tissue, and immunohistochemical findings in the first week and first month. RESULTS:NO and MDA levels in serum and tissue were found to be statistically lower after high-dose methylprednisolone (MP), normal-dose MP, high-dose MP+VA, normal-dose, and MP+VA treatment modalities compared to controls (p<0.05). The most similar EM findings compared to control animals were seen in the normal-dose MP and high-dose MP+VA treatment groups. The best amplitude values were seen in the high-dose MP and continuous normal-dose MP therapy groups in the first month. In the normal-dose MP and high-dose MP+VA treatment groups, intense staining was found compared to the control and sham groups according to the sciatic nerve immunohistochemical examination. CONCLUSION:This study revealed noticeable VA effects on the inflammatory process during the healing of traumatic nerve paralysis by electron microscopy and immunohistochemistry. However, similar findings were not established by electrophysiology. Therefore, more experimental studies are needed to further investigate the efficacy and the mechanism of action of VA on steroid administration and the inflammatory process.

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Section: Discussionmentioning

confidence: 99%

The Effects of Methylprednisolone and Vitamin A on the Healing of Traumatic Peripheral Nerve Paralysis

Sevük¹,

Vayısoğlu²,

Korlu³

et al. 2015

Int Adv Otol

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“…For this purpose, many pharmacological agents are tried experimentally and successful results were reported [9][10][11][12][13][14]. However, these studies did not go beyond the experimental studies.…”

Section: Discussionmentioning

confidence: 99%

“…Although this process is often facilitated by a permissive environment in the periphery, some factors can impede normal return to function, such as the distance from injury site, metabolic disturbances, age and type of lesion [5][6][7][8]. Experimentally, a lot of medications were used in rat crush injury models such as steroids, nonsteroidal anti-inflammatory drugs and vitamins [9][10][11]. Some antioxidants such as Acetyl-L carnitine (ALCAR), FK506, polyethylene glycol (PEG) are used experimentally in treatment of nerve crush injuries [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Effect of Zofenopril on regeneration of sciatic nerve crush injury in a rat model

Kalender

Doğan

Bakan

et al. 2014

J Brachial Plex Peripher Nerve Inj

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BackgroundZofenopril is an antioxidant agent which has been shown to have beneficial effects in hypertension and heart failure. The aim of this study was to test the effects of Zofenopril on nerve regeneration and scarring in a rat model of peripheral nerve crush injury.MethodsTwenty-one adult Sprague-Dawley rats underwent a surgical procedure involving right sciatic nerve crush injury. 15 mg/kg Zofenopril was administered orally to seven rats in group Z for seven days. Seven rats in group S received saline orally for seven days. Seven rats in the control group C received no drug after crush injury. Fourteenth and 42nd days after injury, functional and electromyography assessments of nerves were performed. Functional recovery was analyzed using a walking track assessment, and quantified using the sciatic functional index (SFI). After these evaluations, all rats were sacrificed and microscopic evaluations were performed.ResultsThe Sciatic functional Index (SFI) in group Z on 14th day is different significantly from group S and group C (p = 0.037). But on 42nd day there was no difference between groups (p = 0.278). The statistical analyses of electromyelographic (EMG) studies showed that the latency in group Z is significantly different from group S (p = 0.006) and group C (p = 0.045). But on 42nd day there was no difference between groups like SFI (p = 0.147). The amplitude was evaluated better in group Z than others (p < 0.05). In microscopic evaluation, we observed the highest number of nerve regeneration in the group Z and the lowest in the group C. But it was not significant statistically.ConclusionOur results demonstrate that Zofenopril promotes the regeneration of peripheral nerve injuries in rat models.

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“…ASA at 50 mg/kg/day dose has shown marginally higher functional recovery; however, it was not significant in comparison to normal saline treatment. 23) Hence, the neuroprotective action of ASA following peripheral nerve injuries appears to be dose-dependent. Even though our study shows the topical neuroprotective action of ASA in peripheral nerve injuries, data regarding the molecular mechanisms leading to the neuroprotective action are still lacking.…”

Section: Discussionmentioning

confidence: 99%

“… 26) Its effect on peripheral nerve injuries is reported to be accelerative in a nerve crush model in mice. 23) …”

Section: Introductionmentioning

confidence: 99%

Acetyl Salicylic Acid Locally Enhances Functional Recovery After Sciatic Nerve Transection in Rat

Mohammadi

Amini

Abdollahi-Pirbazari

et al. 2013

Neurol. Med. Chir.(Tokyo)

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Local effect of acetyl salicylic acid (ASA) on peripheral nerve regeneration was studied using a rat sciatic nerve transection model. Forty-five male healthy White Wistar rats were divided into three experimental groups (n = 15), randomly: Sham-operation (SHAM), control (SIL), and ASA-treated (SIL/ASA) groups. In SHAM group after anesthesia left sciatic nerve was exposed through a gluteal muscle incision and after homeostasis the muscle was sutured. In SIL group the left sciatic nerve was exposed the same way and transected proximal to tibio-peroneal bifurcation leaving a 10-mm gap. Proximal and distal stumps were each inserted into a silicone tube and filled with 10 μl phosphate buffered solution. In SIL/ASA group defect was bridged using a silicone tube filled with 10 μl acetyl salisylic acid (0.1 mg/ml). Each group was subdivided into three subgroups of five animals each and were studied 4, 8, and 12 weeks after surgery. Data were analyzed statistically by factorial analysis of variance (ANOVA) and the Bonferroni test for pair-wise comparisons. Functional study confirmed faster and better recovery of regenerated axons in SIL/ASA than in SIL group (p < 0.05). Gastrocnemius muscle mass in SIL/ASA was significantly more than in SIL group. Morphometric indices of regenerated fibers showed that the number and diameter of the myelinated fibers in SIL/ASA were significantly higher than in control group. In immuohistochemistry, location of reactions to S-100 in SIL/ASA was clearly more positive than in SIL group. Response to local treatment of ASA demonstrates that it influences and improves functional recovery of peripheral nerve regeneration.

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Acetyl salicylic acid augments functional recovery following sciatic nerve crush in mice

Cited by 21 publications

References 9 publications

The Effects of Methylprednisolone and Vitamin A on the Healing of Traumatic Peripheral Nerve Paralysis

The Effects of Methylprednisolone and Vitamin A on the Healing of Traumatic Peripheral Nerve Paralysis

Effect of Zofenopril on regeneration of sciatic nerve crush injury in a rat model

Acetyl Salicylic Acid Locally Enhances Functional Recovery After Sciatic Nerve Transection in Rat

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