Acetylation in pathogenesis: Revealing emerging mechanisms and therapeutic prospects

Jiang, Nan; Li, Wenyong; Jiang, Shuanglin; Xie, Ming; Liu, Ran

doi:10.1016/j.biopha.2023.115519

Cited by 6 publications

(1 citation statement)

References 295 publications

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“…The acetylation capacity of mitochondrion-localized acetyltransferases was reported to be correlated with autophagy, apoptosis and oxidative stress 67 - 69 . In prostate cancer, ACAT1 inhibited autophagy or oxidative stress by preventing FUS from transcribing LC3B or scavenging ROS, thereby promoting tumorigenesis 67 .…”

Section: Discussionmentioning

confidence: 99%

ACAT1 promotes proliferation and metastasis of bladder cancer via AKT/GSK3β/c-Myc signaling pathway

Wang,

Shan

et al. 2024

J. Cancer

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Acetyl-CoA acetyltransferase 1 (ACAT1) plays a significant role in the regulation of gene expression and tumorigenesis. However, the biological role of ACAT1 in bladder cancer (BLCA) has yet to be elucidated. This research aimed to elucidate the bioinformatics features and biological functions of ACAT1 in BLCA. Here, we demonstrate that ACAT1 is elevated in BLCA tissues and is correlated with specific clinicopathological features and an unfavorable prognosis for survival in BLCA patients. ACAT1 was identified as an independent risk factor in BLCA. Phenotypically, both in vitro and in vivo , ACAT1 knockdown suppressed BLCA cell proliferation and migration, while ACAT1 overexpression had the opposite effect. Mechanistic assays revealed that ACAT1 enhances BLCA cell proliferation and metastasis through the AKT/GSK3β/c-Myc signaling pathway by modulating the cell cycle and EMT. Taken together, the results of our study reveal that ACAT1 is an oncogenic driver in BLCA that enhances tumor proliferation and metastasis, indicating its potential as a diagnostic and therapeutic target for this disease.

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Section: Discussionmentioning

confidence: 99%

ACAT1 promotes proliferation and metastasis of bladder cancer via AKT/GSK3β/c-Myc signaling pathway

Wang,

Shan

et al. 2024

J. Cancer

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Key Regulators of Parasite Biology Viewed Through a Post‐Translational Modification Repertoire

Zhang,

Jiang,

Chen

2024

Proteomics

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Parasites are the leading causes of morbidity and mortality in both humans and animals, imposing substantial socioeconomic burdens worldwide. Controlling parasitic diseases has become one of the key issues in achieving “One Health”. Most parasites have sophisticated life cycles exhibiting progressive developmental stages, morphologies, and host‐switching, which are controlled by various regulatory machineries including protein post‐translational modifications (PTMs). PTMs have emerged as a key mechanism by which parasites modulate their virulence, developmental transitions, and environmental adaptations. PTMs are enzyme‐mediated additions or removals of chemical groups that dynamically regulate the stability and functions of proteins and confer novel properties, playing vital roles in a variety of biological processes and cellular functions. In this review, we circumscribe how parasites utilize various PTMs to regulate their intricate lives, with a focus on the biological role of PTMs in parasite biology and pathogenesis.

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Chemical probes for the identification of the molecular targets of honokiol

Vázquez-Villa,

Rueda-Zubiaurre,

Fernández

et al. 2025

European Journal of Medicinal Chemistry

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Acetylation in pathogenesis: Revealing emerging mechanisms and therapeutic prospects

Cited by 6 publications

References 295 publications

ACAT1 promotes proliferation and metastasis of bladder cancer via AKT/GSK3β/c-Myc signaling pathway

ACAT1 promotes proliferation and metastasis of bladder cancer via AKT/GSK3β/c-Myc signaling pathway

Key Regulators of Parasite Biology Viewed Through a Post‐Translational Modification Repertoire

Chemical probes for the identification of the molecular targets of honokiol

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