Acetylation of p65Lys310 by p300 in macrophages mediates anti-inflammatory property of berberine

Zhang, Shuchen; Xu, Pingyuan; Zhu, Ziwei; Zhou, Lingyan; Li, Jiao; Zhou, Ruonan; Kan, Yue; Yu, Xizhong; Zhao, Juan; Yu, Junsheng; Yan, Jing; Fang, Penghua; Shang, Wenbin

doi:10.1016/j.redox.2023.102704

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Functional Consequences Of Mtetc Adaptation In Macrophages1

Influence Of Gut Microbes On the Efficacy At Anti-ga Analges...1

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2024

2025

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Cited by 13 publications

(2 citation statements)

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“…Acetyl-CoA is an important cofactor required by HATs. Acetylation of NF-κB subunit p65 at Lys310 site results in the suppressed NF-kB activity leading to attenuation of inflammatory response ( Zhang et al, 2023 ). Acetylation of the Stat6 transcription factor suppresses M2 polarization ( Yu et al, 2019 ).…”

Section: Functional Consequences Of Mtetc Adaptation In Macrophagesmentioning

confidence: 99%

Mitochondrial electron transport chain in macrophage reprogramming: Potential role in antibacterial immune response

Kumar,

Sharma,

Kumar

et al. 2024

Current Research in Immunology

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Section: Functional Consequences Of Mtetc Adaptation In Macrophagesmentioning

confidence: 99%

Mitochondrial electron transport chain in macrophage reprogramming: Potential role in antibacterial immune response

Kumar,

Sharma,

Kumar

et al. 2024

Current Research in Immunology

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“…[Ranunculaceae; Coptidis rhizoma], has been shown to reduce joint inflammation and pain in GA mouse models (Xu et al, 2021). Berberine acts by inhibiting proteins like MyD88, TLR7 and NF-κB p65 through effects on the NLRP3/TLR signaling pathway (Zhang et al, 2023). It also downregulates the levels of inflammatory factors such as TNF-α and IL-6.…”

Section: Influence Of Gut Microbes On the Efficacy At Anti-ga Analges...mentioning

confidence: 99%

Gut-immunity-joint axis: a new therapeutic target for gouty arthritis

Chen,

Luo,

et al. 2024

Front. Pharmacol.

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Gouty arthritis (GA) is an inflammatory disease characterized by pain. The primary goal of current treatment strategies during GA flares remains the reduction of inflammation and pain. Research suggests that the gut microbiota and microbial metabolites contribute to the modulation of the inflammatory mechanism associated with GA, particularly through their effect on macrophage polarization. The increasing understanding of the gut-joint axis emphasizes the importance of this interaction. The primary objective of this review is to summarize existing research on the gut-immune-joint axis in GA, aiming to enhance understanding of the intricate processes and pathogenic pathways associated with pain and inflammation in GA, as documented in the published literature. The refined comprehension of the gut-joint axis may potentially contribute to the future development of analgesic drugs targeting gut microbes for GA.

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Exogenous acetate attenuates inflammatory responses through HIF-1α-dependent glycolysis regulation in macrophage

Li,

Gong,

Zhu

et al. 2024

Cell. Mol. Life Sci.

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Acetylation of p65Lys310 by p300 in macrophages mediates anti-inflammatory property of berberine

Cited by 13 publications

References 50 publications

Mitochondrial electron transport chain in macrophage reprogramming: Potential role in antibacterial immune response

Mitochondrial electron transport chain in macrophage reprogramming: Potential role in antibacterial immune response

Gut-immunity-joint axis: a new therapeutic target for gouty arthritis

Exogenous acetate attenuates inflammatory responses through HIF-1α-dependent glycolysis regulation in macrophage

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