2009
DOI: 10.1007/s10522-009-9237-z
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Acetylcholine and muscarinic receptor function in cerebral cortex of diabetic young and old male Wistar rats and the role of muscarinic receptors in calcium release from pancreatic islets

Abstract: We investigated acetylcholine esterase (AChE) activity, acetylcholine and muscarinic M1, M3 receptors kinetics in the cerebral cortex of young and old streptozotocin induced and insulin treated diabetic rats. The role of muscarinic receptors in intracellular calcium release from pancreatic islets was studied in vitro. Wistar rats of 7 and 90-weeks old were used. All studies were done in cerebral cortex. AChE assay was done by spectrophotometric method. Radioreceptor binding assays were done for Acetylcholine, … Show more

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Cited by 4 publications
(3 citation statements)
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References 90 publications
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“…In the cerebral cortex of 7-week-old STZ rats the number of m 1 -MAChRs decreased by 28 %, while the number of m 3 -MAChRs increased by 30 %. In the cerebral cortex of 90-week-old diabetic rats the number of m 1 -and m 3 -MAChRs increased by 43 and 23 %, respectively, and the level of acetylcholine was significantly increased compared to control (Savitha et al, 2010). These alterations of m 1 -and m 3 -MAChR expression correlate with cholinergic hypofunction in short-term and prolonged STZ-induced DM.…”
Section: Acetylcholine Signalingmentioning
confidence: 79%
“…In the cerebral cortex of 7-week-old STZ rats the number of m 1 -MAChRs decreased by 28 %, while the number of m 3 -MAChRs increased by 30 %. In the cerebral cortex of 90-week-old diabetic rats the number of m 1 -and m 3 -MAChRs increased by 43 and 23 %, respectively, and the level of acetylcholine was significantly increased compared to control (Savitha et al, 2010). These alterations of m 1 -and m 3 -MAChR expression correlate with cholinergic hypofunction in short-term and prolonged STZ-induced DM.…”
Section: Acetylcholine Signalingmentioning
confidence: 79%
“…e degree of alterations and abnormalities in hormonal signaling systems is well correlated with the severity of T1DM and its complications [11,12]. As a result, at the later stages of the disease characterized by pronounced clinical symptoms, there are all reasons to expect the changes in these systems to be much expressed.…”
Section: Introductionmentioning
confidence: 99%
“…The sections were observed and photographed using confocal imaging system (Leica SP 5). The Pixel intensity of each image was calculated using LAS software from Lyca (Savitha et al, 2009a(Savitha et al, , 2009b.…”
Section: Confocal Imagingmentioning
confidence: 99%