Acetylcholinesterase-functionalized two-dimensional photonic crystal for the sensing of G-series nerve agents

Qi, Fenglian; Cao, Yan; Meng, Zihui; Li, Shuguang; Xu, Jin; Hu, Xiaochun; Xue, Min

doi:10.1007/s00216-019-01700-w

Cited by 29 publications

(16 citation statements)

References 36 publications

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“…The synthesis of tricyanofuran hydrazone was easily carried out via azo coupling of TCF comprising a reactive methyl with the diazonium generated from 2-alkyloxy-4-nitroaniline. The chemical structures of the prepared organogelators and related intermediates were supported by 1 H and 13 C NMR spectroscopy, elemental analyses and FT-IR spectral profiles.…”

Section: Synthesis Of Organogelatorsmentioning

confidence: 99%

“…The consequential excessive aggregation of acetylcholine in the synapse neuronal junctions of the nervous system results in instant symptoms, such as hyperventilation, hindered muscle relaxation or loss of human life [6–11] . Detection of those nerve agents has been accomplished by several techniques, such as photonic crystals, electrochemical tools, ion mobility spectroscopy, microcantilevers, optical fibers and biosensors [12–18] . However, most of those techniques demonstrated some limitations, such as high cost, low portability or the necessity of trained personnel.…”

Section: Introductionmentioning

confidence: 99%

“…[6][7][8][9][10][11] Detection of those nerve agents has been accomplished by several techniques, such as photonic crystals, electrochemical tools, ion mobility spectroscopy, microcantilevers, optical fibers and biosensors. [12][13][14][15][16][17][18] However, most of those techniques demonstrated some limitations, such as high cost, low portability or the necessity of trained personnel. The utilization of colorimetric and/or fluorescent sensors has recently gained significance because they have proved to be simple and cost-effective detection tools.…”

Section: Introductionmentioning

confidence: 99%

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Hydrazone‐Based Supramolecular Organogel for Selective Chromogenic Detection of Organophosphorus Nerve Agent Mimic

2021

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Synthesis and spectroscopic characterization of a low molecular mass organogelator based on alkyl chain‐substituted tricyanofuran hydrazone (TCFH) dyes are described for detecting organophosphorus based nerve agent mimic. The reactivity of the prepared TCFH‐based organogel towards diethylchlorophosphonate (DCP) has been examined in organic phases. TCFH chromophore showed a successful gelation ability of different organic solvents. In addition, responsiveness of TCFH to nerve agent mimic with a gel‐sol reversible switching was monitored associated with colorimetric shifting from yellow to blue. The supramolecular self‐assembly of TCFH occurs via van der Waals interactions as well as cooperative π‐π stacking leading to gel formation in organic solvents. Moreover, the existence of nerve agents‐based gases results in a remarkable variation in the rheological behavior of the tricyanofuran hydrazone‐based gel. Scanning electron microscopy (SEM) images demonstrated that the xerogel generated from n‐propanol (n‐PrOH) is able to create fibrous supramolecular architecture with the ability for naked‐eye detection of a nerve agent mimic. The development of TCFH‐based supramolecular organogel in organic solvents was disturbed by the nerve agent mimic presenting a novel detection technique for organophosphorus warfare agents.

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Section: Synthesis Of Organogelatorsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Hydrazone‐Based Supramolecular Organogel for Selective Chromogenic Detection of Organophosphorus Nerve Agent Mimic

2021

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“…Referring to 2D PhC sensors, one can mention the results by Qi et al [80], who developed a tunable acetylcholinesterase (AChE)-functionalized 2D structure for the detection of a real nerve agent, sarin, and observed a linear relationship between the logarithm of the sarin concentration and the particle spacing of the 2D PhC in the range from 7.1 × 10 −14 to 7.1 × 10 −1 mmol/L. The same structure could be the basis for sensing of other G-series nerve agents.…”

Section: Photonic Crystals For Biological Sensingmentioning

confidence: 99%

Photonic Crystal Stimuli-Responsive Chromatic Sensors: A Short Review

et al. 2020

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Photonic crystals (PhC) are spatially ordered structures with lattice parameters comparable to the wavelength of propagating light. Their geometrical and refractive index features lead to an energy band structure for photons, which may allow or forbid the propagation of electromagnetic waves in a limited frequency range. These unique properties have attracted much attention for both theoretical and applied research. Devices such as high-reflection omnidirectional mirrors, low-loss waveguides, and high- and low-reflection coatings have been demonstrated, and several application areas have been explored, from optical communications and color displays to energy harvest and sensors. In this latter area, photonic crystal fibers (PCF) have proven to be very suitable for the development of highly performing sensors, but one-dimensional (1D), two-dimensional (2D) and three-dimensional (3D) PhCs have been successfully employed, too. The working principle of most PhC sensors is based on the fact that any physical phenomenon which affects the periodicity and the refractive index of the PhC structure induces changes in the intensity and spectral characteristics of the reflected, transmitted or diffracted light; thus, optical measurements allow one to sense, for instance, temperature, pressure, strain, chemical parameters, like pH and ionic strength, and the presence of chemical or biological elements. In the present article, after a brief general introduction, we present a review of the state of the art of PhC sensors, with particular reference to our own results in the field of mechanochromic sensors. We believe that PhC sensors based on changes of structural color and mechanochromic effect are able to provide a promising, technologically simple, low-cost platform for further developing devices and functionalities.

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“…Hydrogels have been used previously in nerve agent detection, including studies of the release of entities attached to the gels, 9,10 fluorescence sensors using fluorophore-integrated smart hydrogels, 11 and photonic crystal hydrogel sensors. 12,13 However, these studies induced small changes in the signaling units included in the hydrogel or the particle spacing.…”

Section: Introductionmentioning

confidence: 99%

A Self-Degradable Hydrogel Sensor for a Nerve Agent Tabun Surrogate Through a Self-Propagating Cascade

et al. 2021

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Acetylcholinesterase-functionalized two-dimensional photonic crystal for the sensing of G-series nerve agents

Cited by 29 publications

References 36 publications

Hydrazone‐Based Supramolecular Organogel for Selective Chromogenic Detection of Organophosphorus Nerve Agent Mimic

Hydrazone‐Based Supramolecular Organogel for Selective Chromogenic Detection of Organophosphorus Nerve Agent Mimic

Photonic Crystal Stimuli-Responsive Chromatic Sensors: A Short Review

A Self-Degradable Hydrogel Sensor for a Nerve Agent Tabun Surrogate Through a Self-Propagating Cascade

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