Achados oculares em crianças com toxoplasmose congênita

Soares, Janer Aparecida Silveira; Nasser, Luciano Sólia; Carvalho, Sílvio Fernando Guimarães; Caldeira, Antônio Prates

doi:10.1590/s0004-27492011000400005

Cited by 13 publications

(6 citation statements)

References 17 publications

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“…Similar results were found in a previous study with a similar population, which identified microcephaly in 20.8%, intracranial calcification in 37.5% and chorioretinitis in 54% of the sample 20 . Screening for toxoplasmosis during pregnancy can anticipate the diagnosis so that treatment is performed at gestation, reducing the risk of injury to the NB 11,21 .…”

Section: Discussionmentioning

confidence: 99%

Epidemiological profile of 39 cases of microcephaly caused by congenital infections diagnosed in the state of Rio Grande do Sul between 2015-2017

Friedrich

Herber

Terra

et al. 2019

CBR

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Introduction: Microcephaly is a clinical finding that can arise from congenital anomalies or emerge after childbirth. Maternal infections acquired during pregnancy can result in characteristic brain damage in the newborn (NB), which may be visible even in the fetal stage. To describe the epidemiological profile of newborns with reported microcephaly and diagnosed with congenital infections in the state of Rio Grande do Sul between 2015 and 2017. Methods: A cross-sectional study was carried out on data collected from the Public Health Event Registry as well as from medical records. The investigation included serologies for toxoplasmosis and rubella; polymerase chain reaction (PCR) for Zika virus (ZIKV) in the blood and cytomegalovirus in the urine; non-treponemal tests for syphilis; and brain imaging tests. Results: Of the 257 reported cases of microcephaly, 39 were diagnosed with congenital infections. Severe microcephaly was identified in 13 patients (33.3%) and 51.3% of the cases showed alterations in brain imaging tests. In relation to the diagnosis of congenital infections, three patients (7.7%) were diagnosed with ZIKV, nine (23.1%) with cytomegalovirus, nine (23.1%) with toxoplasmosis, and 18 (46.1%) with congenital syphilis. The three cases of ZIKV showed calcification in brain imaging tests, signs of arthrogryposis, excess occipital skin and irritability, characterizing the typical phenotype of ZIKV infection. Conclusions: Most cases of congenital infection had severe neurological lesions, particularly the cases of ZIKV, which can cause neurodevelopmental delays and sequelae in these infants throughout early childhood.

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Section: Discussionmentioning

confidence: 99%

Epidemiological profile of 39 cases of microcephaly caused by congenital infections diagnosed in the state of Rio Grande do Sul between 2015-2017

Friedrich

Herber

Terra

et al. 2019

CBR

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“…However, when the infection occurs during the third trimester of gestation, the child may be born without evidence of the disease, and may present them years latter Health and Diversity, v.1, p.53-58, 2017(JONES et al, 2003SOUZA et al, 2010). The main manifestation observed in congenital toxoplasmosis is the toxoplasmic retinochoroiditis, being present in 80% of cases (SOARES et al, 2011). However, brain calcifications, mental retardation, hydrocephalus, with macro and microcephaly may also be present in patients who develop this condition (VIDIGAL et al, 2002).…”

Section: Congenital Toxoplasmosismentioning

confidence: 99%

Toxoplasma gondii infection, congenital toxoplasmosis, toxoplasmic retinochoroiditis and neurotoxoplasmosis: an overview

Pavini

Gasparini

Cerni

et al. 2017

RSD

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Introduction: The toxoplasmosis disease resulting from Toxoplasma gondii infection can manifest itself in many ways, however, congenital, ocular and cerebral forms require greater care. The infection by this protozoan is directly related to environmental and economic factors of the region. Objective: The present study, through a review in the literature, aimed to reinforce the knowledge about the infection caused by Toxoplasma gondii and its main clinical manifestations. Methods: This is a literature overview from academic books and scientific articles available in the Scientific Electronic Library Online, US National Library of Medicine National Institutes of Health and Google Scholar databases. To search the publications, the following descriptors were used: Toxoplasma gondii, toxoplasmosis, congenital toxoplasmosis, ocular toxoplasmosis and cerebral toxoplasmosis. The most relevant articles corresponding to the period from 2000 to 2017 were selected. Development: Toxoplasmosis may be of congenital or acquired origin after birth. The congenital form occurs during the embryonic/fetal life and through the passage of Toxoplasma gondii through the transplacental route. Ocular disease is common in both congenital and acquired infections and is closely associated with the presence of neurotoxoplasmosis in AIDS patients. Conclusion: Thus, immunocompromised patients and immunosuppressed patients are considered to be risk groups for Toxoplasma gondii infection.

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“…As daily routine, the cleaning of catteries, with fecal material removal is indicated, since, in dependence on the environmental conditions, the T. gondii oocysts eliminated doi: 10.7243/2052-5958- [1][2][3][4][5][6][7] by cats require at least 24 hours to sporulate and become infectious. It is also important to cover or encircle sand tanks for children recreation, especially when they are not in use, to prevent the cats access [12,33].…”

Section: Control Of Human Toxoplasmosismentioning

confidence: 99%

“…Women in initial stages of gestation may undergo miscarriage, premature birth, neonatal death and even the classical Sabin's Triad, characterized by retinochoroiditis, cerebral calcifications, hydrocephaly or microcephaly [1,2].…”

Section: Introductionmentioning

confidence: 99%

Relevant aspects of human toxoplasmosis

Bresciani¹,

Galvão²,

Vasconcellos³

et al. 2013

Res J Infect Dis

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Considering the great importance that the infection by Toxoplasma gondii has in public health, the aim of this article was to demonstrate some aspects about this disease in human being. This parasite can cause several behavioral changes and many cases of reactivation of this disease are associated with Acquired Immunodeficiency Syndrome -AIDS. Major cases of human infections by T. gondii are assymptomatic and the main clinical manifestation in the acute phase of this zoonosis is lymphadenopathy, usually in the cervical area. There may also be fever, night sweats, myalgia, maculopapular rash lymphocytic atypia and chorioretinitis. The congenital and/or acquired chronic latent cerebral toxoplasmosis play an important role in the development of some types of neurodegeneration, like Alzheimer disease and Down Syndrome. Humans and animals should not consume raw or undercooked meat, unpasteurized or not boiled dairy products, water without being treated and poorly washed fruits and vegetables. Educational programs focused on reducing T. gondii environmental contamination are essential for the congenital infection control. Due to the severity of this kind of infection and its sequel, it is critical that those responsible for the community's health establish prevention programs to avoid such a situation, obtaining results in the medium and long term, and particularly preserving the involved population's welfare. A lack or incomplete prenatal treatment was identified as an important risk factor for congenital toxoplasmosis, reinforcing the need of improvement of prenatal care. In this study was demonstrated the importance of implementing prevention programs to guide pregnant women to prevent the infection. Preventive measures like information and health education; screening of pregnant women and infants; limiting harm from risk behaviour; treatment of risk cases and vaccination are recommended. Serum monitoring throughout pregnancy, so as detect cases of maternal seroconversion allowing for early maternal treatment is also basic. Some countries have adopted control programs of human toxoplasmosis, however, this issue should be of world attention, considering its relevant aspects of public health, requiring the establishment of community education campaigns and monitoring of pregnant women in the pre and neonatal, especially in a preventive action to reduce the pathogenic effects of this disease.

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Achados oculares em crianças com toxoplasmose congênita

Cited by 13 publications

References 17 publications

Epidemiological profile of 39 cases of microcephaly caused by congenital infections diagnosed in the state of Rio Grande do Sul between 2015-2017

Epidemiological profile of 39 cases of microcephaly caused by congenital infections diagnosed in the state of Rio Grande do Sul between 2015-2017

Toxoplasma gondii infection, congenital toxoplasmosis, toxoplasmic retinochoroiditis and neurotoxoplasmosis: an overview

Relevant aspects of human toxoplasmosis

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