Achievement in active agent structures as a power tools in tumor angiogenesis imaging

Staszak, Katarzyna; Wieszczycka, Karolina; Bajek, Anna; Staszak, Maciej; Tylkowski, Bartosz; Roszkowski, Krzysztof

doi:10.1016/j.bbcan.2021.188560

Cited by 2 publications

(1 citation statement)

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“…Computed tomography (CT) and magnetic resonance imaging are routine medical imaging techniques for clinical cancer diagnosis and prognosis evaluation. In contrast to CT, which relies on in vitro x-ray transmission, single-photon emission CT, and positron emission tomography are functional imaging methodologies that rely on in vivo emission from relatively expensive radionuclides ( 17 ). Dynamic contrast–enhanced CT, capable of 3D and large-scale imaging, can be used to describe the pathological structural features of tumor foci ( 18 ).…”

Section: Introductionmentioning

confidence: 99%

Cross-scale tracing of nanoparticles and tumors at the single-cell level using the whole-lung atlas

Cao

Zhao²,

Sun

et al. 2023

Sci. Adv.

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Currently, the effectiveness of oncotherapy is limited by tumor heterogeneities, which presents a huge challenge for the development of nanotargeted drug delivery systems (DDSs). Therefore, it is important to resolve the spatiotemporal interactions between tumors and nanoparticles. However, targeting evaluation has been limited by particle visualization due to the gap between whole-organ scale and subcellular precision. Here, a high-precision three-dimensional (3D) visualization of tumor structure based on the micro-optical sectioning tomography (MOST) system and fluorescence MOST (fMOST) system is presented to clarify 3D spatial distribution of nanoparticles within the tumor. We demonstrate that through the MOST/fMOST system, it is possible to reveal multidimensional and cross-scale correlations between the tumor structure and nanoparticle distribution to remodel the tumor microenvironment and explore the structural parameters of vasculature. This visualization methodology provides an accurate assessment of the efficacy, distribution, and targeting efficiency of DDSs for oncotherapy compared to available approaches.

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Section: Introductionmentioning

confidence: 99%