Acid base balance in pre-eclamptic, hypertensive and diabetic pregnancies. Maternal blood and amniotic fluid studies

He, Fang; Northrop, Gretajo; Hr, Misenhimer; Rj, Harp

doi:10.1515/jpme.1979.7.4.202

Cited by 2 publications

(1 citation statement)

References 14 publications

(27 reference statements)

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“…42 Fadel et al reported no significant difference between arterial levels of lactic acid in women with preeclampsia and healthy pregnant controls. 43 An attempt to use venous lactic acid levels early in pregnancy as a predictor for onset of preeclampsia was not successful. 15 Specific levels of lactic acid reported should be interpreted with caution because many of the studies reporting lactic acid levels did not clarify whether or not patients were in labor at the time of collection.…”

Section: Discussionmentioning

confidence: 99%

Normal Range for Maternal Lactic Acid during Pregnancy and Labor: A Systematic Review and Meta-Analysis of Observational Studies

et al. 2018

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Objective This article systematically reviews the literature to establish the normal range of lactic acid in healthy pregnant women. Study Design Ovid MEDLINE, Embase.com, and Clinicaltrials.gov were searched to identify studies that reported maternal lactic acid in healthy pregnant women. Pooled aggregate means and two standard deviations for each time period were computed using the inverse variance weighting technique. Analyses were performed separately for 1st, 2nd, and 3rd trimesters, scheduled cesarean delivery, early labor, active labor, 2nd stage of labor, and delivery. Results Overall, 22 studies met the inclusion criteria. There were 1,193 patients, and 2,008 observations identified. All time periods had maternal venous lactic acid aggregate means and two-standard-deviation ranges less than 4 mmol/L. Outside of labor, all ranges were less than 2 mmol/L. All labor periods had a range higher than 2 mmol/L. While the pooled ranges were less than 4 mmol/L, many individual studies reported ranges > 4 mmol/L during labor. Conclusion This meta-analysis suggests that venous lactic acid levels can be used as a screening tool in pregnant women just as the test would be used in nonpregnant women, except that elevations may be seen during labor, especially later in labor when there is maximal skeletal muscle contraction.

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Section: Discussionmentioning

confidence: 99%

Normal Range for Maternal Lactic Acid during Pregnancy and Labor: A Systematic Review and Meta-Analysis of Observational Studies

et al. 2018

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Strong ion and weak acid analysis in severe preeclampsia: potential clinical significance

Ortner

Combrinck

Allie

et al. 2015

British Journal of Anaesthesia

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Acid base balance in pre-eclamptic, hypertensive and diabetic pregnancies. Maternal blood and amniotic fluid studies

Abstract: 202Fadel et al., Acid base balance in maternal blood and amniotic fluid J. Perinat. Med.Acid base balance in pre-eclamptic, hypertensive and diabetic pregnancies. Maternal 7 (1979) 195 Wood ^ ^ ^ fl ui d studies

Cited by 2 publications

References 14 publications

Normal Range for Maternal Lactic Acid during Pregnancy and Labor: A Systematic Review and Meta-Analysis of Observational Studies

Normal Range for Maternal Lactic Acid during Pregnancy and Labor: A Systematic Review and Meta-Analysis of Observational Studies

Strong ion and weak acid analysis in severe preeclampsia: potential clinical significance

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