Acid–base management – is it relevant for the study design of hypothermic neuroprotection?

Alpha-Stat Versus pH-Stat Guided Ventilation in Patients with Large Ischemic Stroke Treated by Hypothermia

“…Alpha-stat management is considered to be the standard ventilation mode for patients undergoing cardiac bypass surgery in deep hypothermia [9,10]. In these patients, lower CBF might result in diminished delivery of embolic material to the brain and therefore lead to a better outcome compared to pH-stat ventilation [11].…”