2023
DOI: 10.1038/s41420-023-01624-6
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Acid-sensing ion channel 1a modulation of apoptosis in acidosis-related diseases: implications for therapeutic intervention

Zhenyu Zhang,
Minnan Chen,
Wenjing Zhan
et al.

Abstract: Acid-sensing ion channel 1a (ASIC1a), a prominent member of the acid-sensing ion channel (ASIC) superfamily activated by extracellular protons, is ubiquitously expressed throughout the human body, including the nervous system and peripheral tissues. Excessive accumulation of Ca2+ ions via ASIC1a activation may occur in the acidified microenvironment of blood or local tissues. ASIC1a-mediated Ca2+‑induced apoptosis has been implicated in numerous pathologies, including neurological disorders, cancer, and rheuma… Show more

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Cited by 4 publications
(1 citation statement)
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“…A variety of channels participate in the process of Ca 2+ overload. These include Ca 2+ release channels such as IP 3 and ryanodine receptors, located in the endoplasmic reticulum, as well as storage-type Ca 2+ influx channels Orai1/Stim, acid-sensing ion channels (ASICs), and TRP channels, which are found in the plasma membrane ( 62 , 86 ). Mitochondrial Ca 2+ channels voltage-dependent anion channels (VDACs) and mitochondrial calcium uniporter (MCU) play major roles in transporting Ca 2 + across the outer and inner mitochondrial membranes, respectively ( 87 ).…”
Section: Roles Of Cations In Regulated Cell Deathmentioning
confidence: 99%
“…A variety of channels participate in the process of Ca 2+ overload. These include Ca 2+ release channels such as IP 3 and ryanodine receptors, located in the endoplasmic reticulum, as well as storage-type Ca 2+ influx channels Orai1/Stim, acid-sensing ion channels (ASICs), and TRP channels, which are found in the plasma membrane ( 62 , 86 ). Mitochondrial Ca 2+ channels voltage-dependent anion channels (VDACs) and mitochondrial calcium uniporter (MCU) play major roles in transporting Ca 2 + across the outer and inner mitochondrial membranes, respectively ( 87 ).…”
Section: Roles Of Cations In Regulated Cell Deathmentioning
confidence: 99%