Acid Trip: Zika Virus Goes Off-Pathway during pH-Triggered Membrane Fusion

Abstract

Single-virus measurements reveal unusual details of Zika and liposome fusion, suggesting an off-pathway mechanism.

Curcumin-Poly(sodium 4-styrenesulfonate) Conjugates as Potent Zika Virus Entry Inhibitors

“…Despite intensive global efforts, no specific treatment for ZIKV-associated diseases is currently available, which partially may be attributed to an incomplete understanding of the infection process. , Curcumin, a natural compound with pleiotropic activity, has demonstrated broad-spectrum antiviral properties. − Experimental data have confirmed that curcumin inhibits ZIKV in a dose-dependent manner by preventing virus attachment to the cell surface without disrupting viral RNA . Recent studies have suggested a possible additional mechanism; specifically, curcumin inhibits dengue virus, a flavivirus that is related closely to ZIKV, by allosteric binding to the NS2B-NS3 protease. , Although curcumin shows potential as an antiviral, its effectiveness is hampered by its low solubility and instability in water .…”

“…Despite intensive global efforts, no specific treatment for ZIKV-associated diseases is currently available, 19 which partially may be attributed to an incomplete understanding of the infection process. 20 , 21 Curcumin, a natural compound with pleiotropic activity, has demonstrated broad-spectrum antiviral properties. 22 − 24 Experimental data have confirmed that curcumin inhibits ZIKV in a dose-dependent manner by preventing virus attachment to the cell surface without disrupting viral RNA.…”