Acidic Cannabinoid Decarboxylation

Filer, Crist N.

doi:10.1089/can.2021.0072

Cited by 21 publications

(17 citation statements)

References 113 publications

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“…Strong healing properties are indicated even among drug-resistant bacteria, such as the Staphylococcus aureus strain. Hemp also contains various polyphenols with antioxidant properties, coloring compounds and polysaccharides [ 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 ].…”

Section: Characteristics Of Hemp Plantsmentioning

confidence: 99%

“…Its source may be hemp dust and waste generated during the processing of entire plants, fibers, seeds and leaves in various technological processes. This dust and waste is usually a waste product, but in the future, it may become a potential source of hemp waxes for use as an ingredient in cosmetics or as a natural polymer plasticizer [ 69 ]. They are part of the oil fraction which, according to the data contained in Table 2 given by L. Apostol in his article, has the following composition [ 78 ]:…”

Section: Characteristics Of Hemp Plantsmentioning

confidence: 99%

“…Interestingly, almost all wax esters were lost from hemp waste processed during paper production. The largest amounts of waxes were obtained as a result of supercritical extraction carried out at a temperature of about 50 °C and high pressure of 350 bar [ 69 ].…”

Section: Characteristics Of Hemp Plantsmentioning

confidence: 99%

“…One of Ireland’s exports from the decades to the 1930s was high-quality hemp-based underwear, while Italian hemp-based fabrics were considered one of the best textiles in the world. Hemp was also used to strengthen rotting and fire-resistant carpets, as opposed to artificial, flammable synthetics [ 69 ].…”

Section: Characteristics Of Hemp Plantsmentioning

confidence: 99%

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Hemp and Its Derivatives as a Universal Industrial Raw Material (with Particular Emphasis on the Polymer Industry)—A Review

Tutek

Masek

2022

Materials

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This review article provides basic information about cannabis, its structure, and its impact on human development at the turn of the century. It also contains a brief description of the cultivation and application of these plants in the basic branches of the economy. This overview is also a comprehensive collection of information on the chemical composition of individual cannabis derivatives. It contains the characteristics of the chemical composition as well as the physicochemical and mechanical properties of hemp fibers, oil, extracts and wax, which is unique compared to other review articles. As one of the few articles, it approaches the topic in a holistic and evolutionary way, moving through the plant’s life cycle. Its important element is examples of the use of hemp derivatives in polymer composites based on thermoplastics, elastomers and duroplasts and the influence of these additives on their properties, which cannot be found in other review articles on this subject. It indicates possible directions for further technological development, with particular emphasis on the pro-ecological aspects of these plants. It indicates the gaps and possible research directions in basic knowledge on the use of hemp in elastomers.

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Section: Characteristics Of Hemp Plantsmentioning

confidence: 99%

Section: Characteristics Of Hemp Plantsmentioning

confidence: 99%

Section: Characteristics Of Hemp Plantsmentioning

confidence: 99%

Section: Characteristics Of Hemp Plantsmentioning

confidence: 99%

See 2 more Smart Citations

Hemp and Its Derivatives as a Universal Industrial Raw Material (with Particular Emphasis on the Polymer Industry)—A Review

Tutek

Masek

2022

Materials

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“…these phenomena often lead to the decarboxylation of acidic cannabinoids and the eventual formation of neutral cannabinoids such as cannabidiol (CBD), cannabigerol (CBG), and Δ 9 -tetrahydrocannabinol (Δ 9 -THC) [24][25][26] .…”

Section: Introductionmentioning

confidence: 99%

Decarboxylation of acidic cannabinoids in Cannabis sativa during storage period

Kim,

Park,

Kinney

et al. 2024

Preprint

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This study was conducted to determine the quantity of acidic cannabinoids converted to neutral cannabinoids during the 15-day storage period. The secretory cavity contents acquired from the capitate-stalked glandular trichomes by glass microcapillaries and air-dried inflorescence were analysed by high-pressure liquid chromatography. The ratio of acidic cannabinoids to the total cannabinoids was much lower in the air-dried inflorescence samples compared to the secretory cavity samples as follows. In the secretory cavity content, the percentage of acidic cannabinoids to the total cannabinoids was measured as 86.7% cannabidiolic acid (CBDA), 1.4% cannabigerolic acid (CBGA), 4.1% cannabichromenic acid (CBCA), and 6.4% Δ 9-tetrahydrocannabinolic acid (Δ 9-THCA), respectively. In the air-dried inflorescence, however, the acidic cannabinoids were detected with 42.5% CBDA, 0.4% CBGA, 1.7% CBCA, and 2.4% Δ 9-THCA, respectively. The ratio of cannabidiol (CBD) to cannabidiolic acid (CBDA) was close to 1:95 (w/w) in secretory cavity contents, however, it was roughly 1:20 (w/w) in the air-dried inflorescence. In addition, Δ 9-tetrahydrocannabivarin (Δ 9-THCV) and Δ 9-tetrahydrocannabivarinic acid (Δ 9-THCVA) were only detected in the air-dried inflorescence sample, and the ratio of Δ 9-THCV to Δ 9-THCVA was about 1:20 (w/w). Besides, cannabidivarinic acid (CBDVA) was only observed in the secretory cavity content.

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Simultaneous quantification of terpenes and cannabinoids by reversed-phase LC-APCI-MS/MS in Cannabis sativa L. samples combined with a subsequent chemometric analysis

Raeber,

Poetzsch,

Schmidli

et al. 2024

Anal Bioanal Chem

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Cannabis sativa L. has been the most discussed medicinal plant in recent years. In particular, the dynamic shift from a formerly illicit and tightly controlled substance to a plant recognized for both medicinal and recreational purposes has brought C. sativa into the global spotlight. Due to the ongoing international legalization processes, fast and convenient analytical methods for the quality control of C. sativa flowers for medicinal and recreational purposes are of tremendous interest. In this study, we report the development and validation of a liquid chromatography-tandem mass spectrometry (LC–MS/MS)-based method applying atmospheric pressure chemical ionization (APCI) to fully quantify 16 terpenes and 7 cannabinoids including their acidic forms by a single chromatographic method. The method presented here is unique and simple, as it eliminates the need for derivatization reactions and includes the unconventional analysis of volatile compounds by liquid chromatography. Samples were prepared by a simple and fast ethanolic extraction. Separation was accomplished within 25 min on a reversed-phase C18 column. Method validation was conducted according to international guidelines regarding selectivity, accuracy, precision, robustness, and linearity. Detection was done in multiple reaction monitoring, which allowed the simultaneous quantification of co-eluting analytes applying two selective mass transitions. In addition, due to reproducible in-source decarboxylation, the acidic forms of cannabinoids were reliably quantified using mass transitions of the neutral forms. The accuracy given as the bias was below 15% for all analytes. Matrix effects for cannabinoids were studied by spiking Humulus lupulus extracts with the analytes at varying concentrations. APCI did not show susceptibility toward ion suppression or enhancement. In addition, the recovery effect after spiking was between 80 and 120% for terpenes. Further, 55 authentic C. sativa extracts were fully quantified, and the obtained results for the terpene profiles were compared to state-of-the-art gas chromatography coupled to flame ionization detection. Comparable results were achieved, emphasizing the method’s applicability for cannabinoids and terpenes. Further, acquired metabolite patterns for C. sativa samples were studied, identifying a relationship between cannabinoid and terpene patterns, as well as the abundance of myrcene in CBD-dominant C. sativa strains. Graphical Abstract

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Acidic Cannabinoid Decarboxylation

Cited by 21 publications

References 113 publications

Hemp and Its Derivatives as a Universal Industrial Raw Material (with Particular Emphasis on the Polymer Industry)—A Review

Hemp and Its Derivatives as a Universal Industrial Raw Material (with Particular Emphasis on the Polymer Industry)—A Review

Decarboxylation of acidic cannabinoids in Cannabis sativa during storage period

Simultaneous quantification of terpenes and cannabinoids by reversed-phase LC-APCI-MS/MS in Cannabis sativa L. samples combined with a subsequent chemometric analysis

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