Acidic Conditions Enhance Bactericidal Effects of Sodium Bisulfite on <i>Helicobacter pylori</i>

Murano, Akiyuki; Morinaga, Naoko; Iwamaru, Yoshifumi; Yahiro, Kinnosuke; Tagashira, Motoyuki; Moss, Joel; Tanzawa, Hideki; Noda, Masatoshi

doi:10.1111/j.1523-5378.2005.00299.x

Cited by 12 publications

(8 citation statements)

References 23 publications

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“…However, these 3 bacterial species did not increase in another TPN solution containing lipid (L+AT1V) even at pH5.5 and pH5.9 (Experiment 3), which is the same result as obtained in the solution without lipid (AT1V or S+AT1V); this finding conflicts with the results of Experiment 1. The conflicting results from these 2 TPN solutions may be attributable to the difference in the bisulfite concentrations (ML contains NaHSO 3 at a very low concentration [20 ppm], but L+AT1V contains NaHSO 3 at a relatively high concentration [400 ppm]) because the bactericidal effect of bisulfite is enhanced in acidic conditions 21. Therefore, the additional experiment (Experiment 4) was performed to investigate the effect of bisulfite concentration in the TPN solution containing both lipid and multivitamins (MLV).…”

Section: Discussionmentioning

confidence: 99%

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Growth of Microorganisms in Total Parenteral Nutrition Solutions Containing Lipid

Kubo¹,

Shimono²,

Kaneda³

et al. 2010

Int. J. Med. Sci.

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Background: To identify the microorganisms that can grow rapidly in total parenteral nutrition (TPN) solutions, we investigated the growth of the major causes of catheter-related blood stream infection (Staphylococcus aureus, Serratia marcescens, Bacillus cereus, and Candida albicans) in TPN solutions containing lipid. Methods: The pH value of a TPN solution containing lipid (pH 6.0, containing 20 ppm of NaHSO3) was adjusted by the addition of HCl to 5.7, 5.4, or 4.9. The pH value of another TPN solution (pH5.5, containing 400 ppm of NaHSO3) was adjusted by the addition of NaOH to 5.9, 6.3, or 6.8. A specific number of each microorganism was added to 10 mL of each test solution and incubated at room temperature. The number of microorganisms was counted as colony forming units at 0, 24, and 48 hrs later. Results: C albicans increased similarly at any pH values in the TPN solution. The bacterial species also increased rapidly at pH6.0 in the solution containing 20 ppm of NaHSO3, but growth was suppressed as the pH value was reduced, with growth halted at pH4.9. However, these bacterial species did not increase, even at pH5.9, in the other solution containing 400 ppm of NaHSO3. Conclusions: These results suggest that Candida species can grow rapidly in almost all TPN solutions regardless of the acidity, lipid, and NaHSO3; also, some bacterial species may grow in TPN solutions containing lipid unless the pH value is 5.0 or less. Therefore, each TPN solution should be examined whether or not the bacterial species can proliferate.

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Section: Discussionmentioning

confidence: 99%

“…The results are shown as values of CFU/mL in semi-logarithmic graphs. As other experimental studies of microbial growth,5,12,13,21,22 the data obtained in this study were not analyzed statistically, because biological significance of these kinds of data is considered to be assessable without statistical analysis.…”

Section: Methodsmentioning

confidence: 99%

Growth of Microorganisms in Total Parenteral Nutrition Solutions Containing Lipid

Kubo¹,

Shimono²,

Kaneda³

et al. 2010

Int. J. Med. Sci.

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“…In addition, flow‐cytometric analysis of treated cells implied membrane potential disruption and DNA synthesis inhibition through blocking of DNA gyrase activity. According to the literature, RSV exhibits the most potent inhibitory activity on Helicobacter pylori infection under natural condition (Murano et al., 2005). Chan (2002) evaluated the antimicrobial activity of RSV against bacteria and dermatophytes as skin infection agents and indicated the anti‐fungal effects of RSV.…”

Section: Resveratrol and Diseasesmentioning

confidence: 99%

“…Results from most of these studies indicate that RSV can prevent inhibiting protein synthesis and thus inhibit virus proliferation (Yang et al, 2015). Helicobacter pylori infection under natural condition (Murano et al, 2005). Chan (2002) evaluated the antimicrobial activity of RSV against bacteria and dermatophytes as skin infection agents and indicated the anti-fungal effects of RSV.…”

Section: Antimicrobial and Antiviral Effects Of Resveratrolmentioning

confidence: 99%

Resveratrol: A miraculous natural compound for diseases treatment

Koushki

Amiri-Dashatan

Ahmadi

et al. 2018

Food Science & Nutrition

210

109

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Resveratrol (3, 5, 4′‐trihydroxystilbene) is a nonflavonoid polyphenol that naturally occurs as phytoalexin. It is produced by plant sources such as grapes, apples, blueberries, plums, and peanut. This compound has critical roles in human health and is well known for its diverse biological activities such as antioxidant and anti‐inflammatory properties. Nowadays, due to rising incidence of different diseases such as cancer and diabetes, efforts to find novel and effective disease‐protective agents have led to the identification of plant‐derived compounds such as resveratrol. Furthermore, several in vitro and in vivo studies have revealed the effectiveness of resveratrol in various diseases such as diabetes mellitus, cardiovascular disease, metabolic syndrome, obesity, inflammatory, neurodegenerative, and age‐related diseases. This review presents an overview of currently available studies on preventive properties and essential molecular mechanisms involved in various diseases.

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“…Resveratrol, a polyphenol found in wine, is known to exhibit the most potent inhibitory activity on H. pylori infection under neutral conditions 31 . The bactericidal effect of sodium bisulfite on H. pylori was greater under acidic conditions and independent of urease activity 31 . In addition, resveratrol and red wine extracts inhibited the growth of cag A + strains of H. pylori in vitro 32 .…”

Section: Phytoceuticals For Modulating H Pylori: a Better Option Thamentioning

confidence: 99%

Phytoceuticals: Mighty but ignored weapons against Helicobacter pylori infection

Lee

Shin

Hahm

2008

J of Digest Diseases

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Helicobacter pylori (H. pylori) infection causes peptic ulcer disease, mucosa‐associated lymphoid tissue (MALT) lymphomas and gastric adenocarcinomas, for which the pathogenesis of chronic gastric inflammation prevails and provides the pathogenic basis. Since the role of H. pylori infection is promoting carcinogenesis rather than acting as a direct carcinogen, as several publications show, eradication alone cannot be the right answer for preventing H. pylori‐associated gastric cancer. Therefore, a non‐antimicrobial approach has been suggested to attain microbe‐associated cancer prevention through controlling H. pylori‐related chronic inflammatory processes and mediators responsible for carcinogenesis. Phytoceutical is a term for plant products that are active on biological systems. Phytoceuticals such as Korean red ginseng, green tea, red wine, flavonoids, broccoli sprouts, garlic, probiotics and flavonoids are known to inhibit H. pylori colonization, decrease gastric inflammation by inhibiting cytokine and chemokine release, and repress precancerous changes by inhibiting nuclear factor‐kappa B DNA binding, inducing profuse levels of apoptosis and inhibiting mutagenesis. Even though further unsolved issues are awaited before phytoceuticals are accepted as a standard treatment for H. pylori infection, phytoceuticals can be a mighty weapon for either suppressing or modulating the disease‐associated footprints of H. pylori infection.

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Acidic Conditions Enhance Bactericidal Effects of Sodium Bisulfite on Helicobacter pylori

Abstract: The bactericidal effect of sodium bisulfite on H. pylori was greater under acidic conditions and independent of urease activity.

Cited by 12 publications

References 23 publications

Growth of Microorganisms in Total Parenteral Nutrition Solutions Containing Lipid

Growth of Microorganisms in Total Parenteral Nutrition Solutions Containing Lipid

Resveratrol: A miraculous natural compound for diseases treatment

Phytoceuticals: Mighty but ignored weapons against Helicobacter pylori infection

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