Acneiform eruptions caused by vitamin B12: A report of five cases and review of the literature

Abstract

We describe five cases of acneiform eruption caused by vitamin B12 in five females aged 37, 32, 62, 29, and 21 years, respectively. The eruption appeared from 1 week to 5 months after the beginning of the therapy with i.m. or oral vitamin B12. Clinical picture was characterized by papules and pustules located on the face. In three patients, similar lesions were also present on the neck, shoulders, chest, and upper portion of the back. Comedones and cysts were absent. In two patients, serum vitamin B12 levels were very high. Histopathologic examination in one patient revealed an eosinophilic folliculitis. Spontaneous and complete remission was observed in all patients 3-6 weeks after vitamin B12 discontinuation.

Irritant contact dermatitis due to Euphorbia trigona

“…It is traditionally used to treat skin cancers, actinic keratosis, and digestive system disorders . Many species of Euphorbia typically have a milky sap that can cause irritant reactions, including E. helioscopia , E. pulcherrima , E. marginata , E. myrsinites , and E. hermentiana . E. trigona , known as African milk tree, also produces a milky sap which causes irritant contact dermatitis.…”

Acné en alumnos de medicina humana y sus factores asociados

“…El consumo de suplemento vitamínico B no se relaciona con la presencia de acné. En Canadá encontraron que una forma de amida de la Vitamina B3 es beneficiosa en una variedad de afecciones de la piel como el acné (24), semejante a lo mostrado por Veraldi donde sugieren que la vitamina B12 tiene un rol patogénico en el desarrollo de erupciones acneiformes (25). Kang y cols.…”

Acneiform eruption associated with the use of vortioxetine

“…The lesions can sometimes be itchy. After drug withdrawal, they heal spontaneously depending on the half-life of the drug [8].…”