Acoustic Centrifugation Facilitating Particle Sensing in Liquid on a Piezoelectric Resonator

Qian, Jingui; Begum, Habiba; Lee, Joshua

doi:10.1109/led.2022.3162327

Cited by 7 publications

(3 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As such, we demonstrate that our high throughput acoustofluidic platform can aggregate different cells and of different cluster sizes, which can be a useful tool in the fabrication of 3D tumor spheroids. Moreover, as an open-channel approach, our acoustofluidic device can be further integrated with other functional chips such as bio-sensors for deeper cell analysis [25,26].…”

Section: Multi-sample Acoustofluidic Device For Cell Aggregationsmentioning

confidence: 99%

Developing a multi-sample acoustofluidic device for high-throughput cell aggregation

Yang

Huang

Zhang

et al. 2023

J. Micromech. Microeng.

Self Cite

View full text Add to dashboard Cite

Plug-and-play acoustofluidic devices are highly promising for dexterously aggregating microparticles owing to the advantages of being contactless, label-free, and cost-efficient.Despite extensive achievement, existing acoustofluidic devices are largely limited to one sample and lack the ability to achieve multi-sample, high-throughput operations in a single acoustofluidic device. In this work, we report a high-throughput multi-sample acoustofluidic aggregation device that enables to manipulate up to 12 samples simultaneously using a single reusable acoustic tweezer. The key design of multi-sample acoustofluidic device lies in the utilization of polydimethylsiloxane (PDMS) frame as a selective acoustic-absorbing platform to create asymmetric acoustic waves over multiple detachable superstrates in a single device, which are highly distinct from the conventional strategies by modifying any of the superstrates or tuning settings for individual superstrates. We demonstrate that the acoustofluidic device can high-efficiently, arbitrarily aggregate multiple samples of various compositions ranging from non-bioactive microparticles to bioactive cells, as well as a range of object sizes spanning from 0.6 µm to 13 µm. With the merits of simplicity, cost-efficiency and high throughput, the proposed platform in this work can also find some promising biomedical applications requiring large-scale operations, such as 3D tumor spheroids and bio-sensors.

show abstract

Section: Multi-sample Acoustofluidic Device For Cell Aggregationsmentioning

confidence: 99%

Developing a multi-sample acoustofluidic device for high-throughput cell aggregation

Yang

Huang

Zhang

et al. 2023

J. Micromech. Microeng.

Self Cite

View full text Add to dashboard Cite

show abstract

“…Owing to their good tensile properties, flexible strain sensors are commonly used in specific wearable devices and flexible electronics − to monitor muscle and joint motion through skin deformation. − However, several challenges must be addressed for practical application of these sensors. The first challenge is to improve the torsional interference resistance of the sensor.…”

Section: Introductionmentioning

confidence: 99%

Flexible Strain Sensor Based on Copper/Graphene Composite Films

Zhu,

Zhang,

Lin

et al. 2023

ACS Appl. Nano Mater.

View full text Add to dashboard Cite

This study analyzed a flexible strain sensor with torsional low interference, waterproofing, and self-adhesive properties using a copper/ graphene microcrack composite film as a strain-sensitive layer and a selfadhesive silica gel as a waterproofing and self-adhesive layer. The sensor exhibits a wide response range (with a strain capability of up to 110%), high sensitivity (with a gauge factor of 847.87 (92% < ε < 110%)), and satisfactory sensing durability (with response cycles of 10000 under 25% strain) and can detect ultrasmall strains (0.2% strain). In addition, the sensor exhibits similar real-time dynamic responses at different strain levels (0%−40%) and states (untwisted, twisted by 90°, and twisted by 180°), indicating its characteristic of torsional low interference. Moreover, the self-adhesive silica gel allows the sensor to directly adhere to the skin surface, reducing motion artifacts and improving the accuracy of monitoring complex strain states during underwater activities. Therefore, the flexible strain sensor holds potential as a nextgeneration flexible strain sensor for underwater use.

show abstract

“…These features consequently enable improvements in terms of phase noise and frequency stability of the oscillator implementation that integrates the piezoelectric-on-silicon resonator as the frequency determining element [ 25 ]. Leveraging these benefits of piezoelectric transduction, several papers in the literature have demonstrated applications to gravimetric sensing including to particulate matter detection and mass sensing in liquids [ 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 ].…”

Section: Introductionmentioning

confidence: 99%

Towards Portable MEMS Oscillators for Sensing Nanoparticles

Chellasivalingam

Zielinski

Whitney

et al. 2022

Sensors

View full text Add to dashboard Cite

This paper reports on the design, and implementation of piezoelectric-on-silicon MEMS resonators installed within a portable experimental setup for sensing nanoparticles in a laboratory environment. MEMS oscillators with a center frequency of approximately 5.999 MHz are employed for sensing 50 nm size-selected silver nanoparticles generated in the laboratory. The same experimental setup is then assembled to sense indoor particles that are present in the laboratory environment. The challenges associated with particle deposition as a result of assembling the portable experimental setup is highlighted. Furthermore, the MEMS oscillators demonstrate that the total mass of silver nanoparticles deposited onto the MEMS resonator surface using the inertial impaction technique-based experimental setup is approximately 7.993 nanograms. The total indoor particle mass accumulated on the MEMS resonator surface is estimated to be approximately 1.732 nanograms and 26.9 picograms for two different runs. The frequency resolution of the MEMS oscillator is estimated to be approximately 32 ppb and, consequently, the minimum detectable particle mass is approximately 60 femtograms for a 9.2 s integration time.

show abstract

Acoustic Centrifugation Facilitating Particle Sensing in Liquid on a Piezoelectric Resonator

Cited by 7 publications

References 27 publications

Developing a multi-sample acoustofluidic device for high-throughput cell aggregation

Developing a multi-sample acoustofluidic device for high-throughput cell aggregation

Flexible Strain Sensor Based on Copper/Graphene Composite Films

Towards Portable MEMS Oscillators for Sensing Nanoparticles

Contact Info

Product

Resources

About