Acoustic stimulation during slow wave sleep shows delayed effects on memory performance in older adults

Wunderlin, Marina; Zeller, Céline J.; Wicki, Korian; Nissen, Christoph; Züst, Marc A.

doi:10.3389/frsle.2023.1294957

Cited by 4 publications

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Multi-night acoustic stimulation is associated with better sleep, amyloid dynamics, and memory in older adults with cognitive impairment

Zeller,

Wunderlin,

Wicki

et al. 2024

GeroScience

View full text Add to dashboard Cite

Sleep is a potential early, modifiable risk factor for cognitive decline and dementia. Impaired slow wave sleep (SWS) is pronounced in individuals with cognitive impairment (CI). Cognitive decline and impairments of SWS are bi-directionally linked in a vicious cycle. SWS can be enhanced non-invasively using phase-locked acoustic stimulation (PLAS), potentially breaking this vicious cycle. Eighteen healthy older adults (HC, agemean±sd, 68.3 ± 5.1) and 16 older adults (agemean±sd, 71.9 ± 3.9) with CI (Montreal Cognitive Assessment ≤ 25) underwent one baseline (sham-PLAS) night and three consecutive stimulation nights (real-PLAS). EEG responses and blood-plasma amyloid beta Aβ42/Aβ40 ratio were measured pre- and post-intervention, as was episodic memory. The latter was again evaluated 1 week and 3 months after the intervention. In both groups, PLAS induced a significant electrophysiological response in both voltage- and time–frequency analyses, and memory performance improved in association with the magnitude of this response. In the CI group, both electrophysiological and associated memory effects were delayed compared to the healthy group. After 3 intervention nights, electrophysiological response to PLAS was no longer different between CI and HC groups. Only in the CI sample, stronger electrophysiological responses were significantly associated with improving post-intervention Aβ42/Aβ40 ratios. PLAS seems to improve SWS electrophysiology, memory, and amyloid dynamics in older adults with CI. However, effects on memory require more time to unfold compared to healthy older adults. This indicates that PLAS may become a potential tool to ameliorate cognitive decline, but longer interventions are necessary to compensate for declining brain integrity. This study was pre-registered (clinicaltrials.gov: NCT04277104).

show abstract

Multi-night acoustic stimulation is associated with better sleep, amyloid dynamics, and memory in older adults with cognitive impairment

Zeller,

Wunderlin,

Wicki

et al. 2024

GeroScience

View full text Add to dashboard Cite

show abstract

Current and Emerging Sleep Interventions for Older Adults with or without Mild Cognitive Impairment

Suraev,

Kong,

Menczel Schrire

et al. 2024

Curr Treat Options Neurol

View full text Add to dashboard Cite

Purpose of Review This systematic scoping review examines evidence from the last five years on sleep interventions in cognitive healthy older adults and those with mild cognitive impairment. Recent Findings Sleep disturbance has been identified as a potential early, modifiable risk factor for dementia, making it crucial to investigate if these interventions also enhance cognitive function and neurodegenerative biomarkers. Summary Since 2019, research on sleep interventions in older adults with or without cognitive impairment has gradually expanded, especially on non-pharmacological treatments including CBT-I, exercise, and multi-modal interventions, which show promise but require further study to confirm cognitive benefits. Pharmacological interventions have primarily focused on melatonin and orexin antagonists, with long-term safety remaining a concern. Tailored, clinically effective interventions that consider the presence of Alzheimer’s disease biomarkers, such as amyloid, tau, cerebrovascular disease, or alpha-synuclein in key sleep-related circuits, are essential to developing feasible, cost-effective, and scalable treatments for older adults with or without cognitive impairment.

show abstract

mCLAS adaptively rescues disease-specific sleep and wake phenotypes in neurodegeneration

Dias,

Baumann,

Noain

2024

Sleep Medicine

View full text Add to dashboard Cite

Acoustic stimulation during slow wave sleep shows delayed effects on memory performance in older adults

Cited by 4 publications

References 32 publications

Multi-night acoustic stimulation is associated with better sleep, amyloid dynamics, and memory in older adults with cognitive impairment

Multi-night acoustic stimulation is associated with better sleep, amyloid dynamics, and memory in older adults with cognitive impairment

Current and Emerging Sleep Interventions for Older Adults with or without Mild Cognitive Impairment

mCLAS adaptively rescues disease-specific sleep and wake phenotypes in neurodegeneration

Contact Info

Product

Resources

About