Acoustic virtual 3D scaffold for direct-interacting tumor organoid–immune cell coculture systems
Han Shan,
Maike Chen,
Shuang Zhao
et al.
Abstract:Three-dimensional (3D) cell culture has revolutionized life sciences, particularly in organoid technologies. Traditional bioscaffold materials, however, complicate the detachment of tumor organoids and hamper the routine use of organoid–immune cell cocultures. Here, we show an acoustic virtual 3D scaffold (AV-Scaf) method to achieve 3D tumor organoid culture, enabling a direct-interacting tumor organoid–immune cell coculture system. The self-organization process of tumor cells is facilitated by a vortex acoust… Show more
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