Acoustically active perfluorocarbon nanoemulsions as drug delivery carriers for camptothecin: Drug release and cytotoxicity against cancer cells

Fang, Jia‐You; Hung, Chi‐Feng; Hua, Shu-Chiou; Hwang, Tsong‐Long

doi:10.1016/j.ultras.2008.04.009

Cited by 84 publications

(49 citation statements)

References 38 publications

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“…Formulations with phosphatidylethanolamine as an emulsifier showed less hemolysis than those with phosphatidylcholine. With low oil concentration release of camptothecin from the system to the targeting area can be increased 72 .…”

Section: Targeted Drug Deliverymentioning

confidence: 99%

Untitled

2015

IJPSR

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Since last decade, the interdisciplinary research of Nanoemulsions (NEs) have gained great attention in research and drug designing owing to their promising range of applications in the field of pharmaceutics, drug delivery through different route, cosmetics, to name a few. In addition to the small droplet size these non-equilibrium liquid systems have interesting properties including optical clarity, preparatory ease, thermodynamic stability, high bioavailability, resistant to creaming, flocculation, coalescence and sedimentation, low viscosity and increased surface area, among others. Due to these peculiar properties, NEs have become an authentic tool in the drug delivery system. This article pertains to the types of NEs, characterization techniques, different methods of preparation of stable NEs with special emphasis on the various routes by which drug formulated NEs can be administered. Recent advancements of the fascinating applications of NEs in the delivery of the usually hydrophobic drugs and other bio actives/biotechnology, pharmaceutical ingredients are highlighted.

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Section: Targeted Drug Deliverymentioning

confidence: 99%

Untitled

2015

IJPSR

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“…The [18,19,20,21] Experimental:-A sample of Aceclophenac was procured from Sigma Aldrich Company of 99.9% purity.Leucine and DMSO of AR grade were also procured from Sigma Aldrich Company with 99.9 % purity. Ultrasonic Velocity was measured by Ultrasonic interferometer (M-81-S) model at 2 MHz frequency.All measurements were done under atmospheric condition.The density measurement was done by densitometer (Anton par DSA 5000 model) with a resolution of 10 -6 gm cm -3 and viscosity was measured in Oswald's viscometer distilled by calibrating with doubly distilled water with an accuracy of + 0.001 Pa Sec.…”

Section: Introduction:-mentioning

confidence: 99%

Molecular Interaction of Non-Steroid Anti-Inflammatory Drug Aceclophenac With Leucine in Dmso Medium: An Ultrasonic Study.

Pradhan¹,

Das²,

Sahoo³

et al. 2017

IJAR

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Non steroidal anti-inflammatory drug aceclophenac has hydrophobic and hydrophilic domain. It is sparingly soluble in water and miscible in blood due to hydrophilic nature. It exhibits analgesic, antipyretic and anti-inflammatory activities. It is best used in rheumatoid arthritis. It is inhibitor of clotting in the blood vessel, thus prevents heart attack and stroke. Leucine is an essential α-amino acid used in biosynthesis of protein and also used for muscle building. It contains α-amino group, carboxylic acid group and an isobutyl side chain. Ultrasonic study of Aceclophenac with Leucine in DMSO medium provides much useful information about the nature of their molecular interaction in a polar aqua-organic medium. In our body drug interaction with protein play very vital role in the biological process. Because of the 3D structure of protein, it is quite difficult to study its interaction with drugs in the biological system. As amino acid is a model component for protein, in this piece of work we have studied the drug amino acid molecular interaction with variation of concentration of amino acid ranging from 0.002-0.01 mol/kg and the drug concentration varies from 0.0002-0.001 mol/kg. The different acoustic parameters like adiabatic compressibility (β), intermolecular free length (L f ),acoustic impedance(z),apparent molar volume(V φ ),apparent molar compressibility (K φ ),partial molar volume (V φ o ),partial molar compressibility (K φ o ),John Dole coefficient A,B are calculated from density (ρ),ultrasonic velocities (U) and viscosity ( ) data. The parameters are calculated at 298.15K in a polar aprotic medium i.e. taking DMSO as solvent are interpreted in terms of ion-solvent, ionion and ion-dipole interactions considering the structure breaking and structure making aspects of the solvent.Copy Right, IJAR, 2017,. All rights reserved.

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“…79,80 CPT is a potent antineoplastic drug that has activity against a vast array of solid tumors, including ovarian, gastric, breast, cervical, melanoma, skin, and lung cancers. [80][81][82] CPT inhibits and stabilizes the International Journal of Nanomedicine 2014:9 Figure 5 illustrates the reversible conversion from lactone to carboxylate form under physiological conditions. It is therefore essential to protect this lactone group in the formulation and delivery of CPT preparations.…”

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confidence: 99%

“…Although derivatives of CPT are used, they lack the potency of the parent drug. 82,86 Furthermore, CPT and its derivatives usually require continuous infusion over a period of time, or multiple injections over a short period, which is a great disadvantage with regard to patient comfort and acceptability. 87 In addition, prolonged administration results in intolerable adverse effects, including neutropenia, anemia, and other related hematologic manifestations, altered gastric function, and dermatological manifestations.…”

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confidence: 99%

Overview of the role of nanotechnological innovations in the detection and treatment of solid tumors

Frank¹,

Tyagi²,

Tomar³

et al. 2014

IJN

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Nanotechnology, although still in its infantile stages, has the potential to revolutionize the diagnosis, treatment, and monitoring of disease progression and success of therapy for numerous diseases and conditions, not least of which is cancer. As it is a leading cause of mortality worldwide, early cancer detection, as well as safe and efficacious therapeutic intervention, will be indispensable in improving the prognosis related to cancers and overall survival rate, as well as health-related quality of life of patients diagnosed with cancer. The development of a relatively new field of nanomedicine, which combines various domains and technologies including nanotechnology, medicine, biology, pharmacology, mathematics, physics, and chemistry, has yielded different approaches to addressing these challenges. Of particular relevance in cancer, nanosystems have shown appreciable success in the realm of diagnosis and treatment. Characteristics attributable to these systems on account of the nanoscale size range allow for individualization of therapy, passive targeting, the attachment of targeting moieties for more specific targeting, minimally invasive procedures, and real-time imaging and monitoring of in vivo processes. Furthermore, incorporation into nanosystems may have the potential to reintroduce into clinical practice drugs that are no longer used because of various shortfalls, as well as aid in the registration of new, potent drugs with suboptimal pharmacokinetic profiles. Research into the development of nanosystems for cancer diagnosis and therapy is thus a rapidly emerging and viable field of study.

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Acoustically active perfluorocarbon nanoemulsions as drug delivery carriers for camptothecin: Drug release and cytotoxicity against cancer cells

Cited by 84 publications

References 38 publications

Untitled

Untitled

Molecular Interaction of Non-Steroid Anti-Inflammatory Drug Aceclophenac With Leucine in Dmso Medium: An Ultrasonic Study.

Overview of the role of nanotechnological innovations in the detection and treatment of solid tumors

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