Acquired coagulation factor deficiencies in leukemia

Abstract

Isolated Factor V and X deficiencies were associated with acute leukemia in 2 patients. Both patients manifested a hemorrhagic diathesis. in the patient with Factor V deficiency, the level of Factor V was related to the activity of his leukemia. the mechanism of these deficiencies is unclear, but therapy should be directed to correcting the hemostatic mechanism until a hematologic remission can be attained.

Hypofibrinogenemia in non-M3 acute myeloid leukemia. Incidence, clinical and laboratory characteristics and prognosis

“…19 Factor V and VIII deficiencies have been described in patients with AML and DIC. 20 There was no deficiency of factor V and VIII in our cases; however, the DIC patients has a significantly lower factor VIII value compared to non-DIC patients.…”

Mechanisms of Hemorrhage in Leukemias

“…The mean prothrombin level, measured in 50 of our patients, was about 71% of normal [96]. Data concerning Factor V activity are controversial at this time, since normal, increased, and decreased levels have been observed [18,57,133]. There are only a few observations on Factor VII activity in patients with acute leukemia.…”

“…The decreased activity of Factor X correlated with the low activity of the other vitamin K-dependent clotting factors. An isolated acquired Factor X deficiency has been demonstrated in only a few patients [57].…”

Obituary Harvey R. Gralnick, MD (1937–2020)

“…Harvey presided over the rounds with an encyclopedic knowledge of hematologic disease, offering insights and suggestions. These opened up opportunities for collaborations with investigators in the different Institutes, including a series of papers on the coagulation abnormalities associated with congenital heart disease 3,4 and leukemia 5,6 …”

“…These opened up opportunities for collaborations with investigators in the different Institutes, including a series of papers on the coagulation abnormalities associated with congenital heart disease 3,4 and leukemia. 5,6 With Richard Hirschman, he developed novel assays for detecting antiplatelet antibodies to improve platelet transfusion therapy. 7,8 His pioneering studies on the hemorrhagic diathesis associated with acute promyelocytic leukemia encompassed the first description of the tissue factor-like activity of the acute promyelocytic leukemia granules, 9 an ultrastructural analysis with Henry Tan and Bettye Wages, 10 and a careful description of the clinical syndrome and the most appropriate therapy.…”