ACR testing of a dedicated head SPECT unit

Sensakovic, William F.; Hough, Matthew; Kimbley, Elizabeth A.

doi:10.1120/jacmp.v15i4.4632

Cited by 9 publications

(9 citation statements)

References 2 publications

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“…The aim of the present study was to reproduce previous findings [ 6 ] and to evaluate additional phantom measurements relevant for DAT imaging. Therefore, in addition to typical NEMA testing setup for gamma cameras (NU 1-2012) [ 7 ], several tests were adapted from NU 2-2012 [ 8 ], originally designed to evaluate performance of PET systems, to augment conventional SPECT testing.…”

Section: Methodsmentioning

confidence: 91%

“…The aim of the present study was to examine the performance of the system in more detail with respect to clinical DAT imaging. By scanning a small Jaszczak phantom, Sensakovic et al [ 6 ] showed that the InSPira surpassed American College of Radiology (ACR) requirements. The present study aimed to reproduce previous findings by Sensakovic et al [ 6 ] on visible spheres, sphere contrast, visible rod groups, and uniformity using a small Jaszczak phantom.…”

Section: Introductionmentioning

confidence: 99%

“…By scanning a small Jaszczak phantom, Sensakovic et al [ 6 ] showed that the InSPira surpassed American College of Radiology (ACR) requirements. The present study aimed to reproduce previous findings by Sensakovic et al [ 6 ] on visible spheres, sphere contrast, visible rod groups, and uniformity using a small Jaszczak phantom. Spatial resolution in air and water, as well as regional quantification was explored, focusing on DAT imaging by using a striatal phantom.…”

Section: Introductionmentioning

confidence: 99%

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Performance evaluation of a novel brain-dedicated SPECT system

et al. 2018

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BackgroundSingle-photon emission computed tomography (SPECT) imaging is an important diagnostic tool for the early detection of the loss of nigrostriatal dopaminergic neurons in Parkinson’s disease (PD) and similar neurodegenerative disorders. Visualization and quantification of dopamine transporter (DAT) binding in the striatum is an established diagnostic tool to detect nigrostriatal dopaminergic degeneration. Given the small size of the striatum, high-resolution imaging is recommended. The InSPira HD system, a novel brain-dedicated SPECT scanner, allows for such detailed information with a spatial resolution down to ~ 3 mm full width at half maximum (FWHM). The current study examines performance of the InSPira HD for DAT imaging, by combining phantom tests from NU 1-2012 and NU 2-2012, and striatal scans.Due to the unique geometry of the InSPira, and fixed acquisition and reconstruction settings, standard National Electrical Manufacturers Association (NEMA) testing is not applicable. Therefore, a combination of NU 1-2012 and NU 2-2012 standards were applied, with modifications to accommodate the InSPira HD. A small Jaszczak phantom with hot spheres and cold rod inserts was used to determine recovery coefficients, contrast, and uniformity. Spatial resolution was evaluated across the field of view (FOV) for point and line sources in air and water. A striatal phantom was used to model DAT imaging. A clinical, a high-resolution, and an experimental research reconstruction method were compared.ResultsAcquired SPECT images demonstrated spatial resolution in air of ~ 3 mm in the center in the FOV for the high-resolution reconstruction approach. Spatial resolution in air for the clinical and research reconstruction approach was ~ 6–8 mm in the center of the FOV, which decreased in the transaxial plane with increasing radial distance from the center of the FOV. Reconstructed images of the uniform area of the Jaszczak phantom showed limited variability with a coefficient of variation of 2.6% for the clinical reconstruction and 3.0% for the research reconstruction. The ≥ 6-mm rod group and all spheres were resolved for the clinical and research reconstruction approaches. Recovery coefficients (RCs) for the Jaszczak phantom ranged from 0.49 to 0.89 (sphere diameters between 9.8 and 31.2 mm). RCs for the striatal phantom ranged from 0.50 to 0.55, with linearity of striatal ratios for a range of background concentrations (R = 0.97).ConclusionsResults from the phantom data demonstrated acceptable image quality for the InSPira HD system for DAT SPECT imaging in humans.

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Section: Methodsmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Performance evaluation of a novel brain-dedicated SPECT system

et al. 2018

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“…Different image quality parameters such as uniformity, root mean square (rms) value, and contrast[ 12 ] were computed for each data set of SPECT/CT images, obtained by external filter and that without any external filter. Parameters were then compared and studied for change in different image sets.…”

Section: Methodsmentioning

confidence: 99%

Evaluation of external beam hardening filters on image quality of computed tomography and single photon emission computed tomography/computed tomography

Rana¹,

Rawat²,

Parmar³

et al. 2015

J Med Phys

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This study was undertaken to evaluate the effect of external metal filters on the image quality of computed tomography (CT) and single photon emission computed tomography (SPECT)/CT images. Images of Jaszack phantom filled with water and containing iodine contrast filled syringes were acquired using CT (120 kV, 2.5 mA) component of SPECT/CT system, ensuring fixation of filter on X-ray collimator. Different thickness of filters of Al and Cu (1 mm, 2 mm, 3 mm, and 4 mm) and filter combinations Cu 1 mm, Cu 2 mm, Cu 3 mm each in combination with Al (1 mm, 2 mm, 3 mm, and 4 mm), respectively, were used. All image sets were visually analyzed for streak artifacts and contrast to noise ratio (CNR) was derived. Similar acquisition was done using Philips CT quality control (QC) phantom and CNR were calculated for its lexan, perspex, and teflon inserts. Attenuation corrected SPECT/CT images of Jaszack phantom filled with 444–555 MBq (12–15 mCi) of 99mTc were obtained by applying attenuation correction map generated by hardened X-ray beam for different filter combination, on SPECT data. Uniformity, root mean square (rms) and contrast were calculated in all image sets. Less streak artifacts at iodine water interface were observed in images acquired using external filters as compared to those without a filter. CNR for syringes, spheres, and inserts of Philips CT QC phantom was almost similar to Al 2 mm, Al 3 mm, and without the use of filters. CNR decreased with increasing copper thickness and other filter combinations. Uniformity and rms were lower, and value of contrast was higher for SPECT/CT images when CT was acquired with Al 2 mm and 3 mm filter than for images acquired without a filter. The study suggests that for Infinia Hawkeye 4, SPECT/CT system, Al 2 mm, and 3 mm are the optimum filters for improving image quality of SPECT/CT images of Jaszack or Philips CT QC phantom keeping other parameters of CT constant.

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“…The InSPira HD system (InSPira; Neurologica, Danvers, MA, USA) is a novel brain-dedicated single-photon emission computed tomography (SPECT) system which differs from conventional SPECT scanners with respect to hardware configuration and scanning geometry [ 1 ]. Performance of the InSPira system was investigated extensively using phantom data by our group [ 2 ].…”

Section: Rationalementioning

confidence: 99%

Clinical evaluation of [123I]FP-CIT SPECT scans on the novel brain-dedicated InSPira HD SPECT system: a head-to-head comparison

et al. 2018

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The InSPira HD system, a novel brain-dedicated SPECT scanner, allows for imaging with a high spatial resolution. Here, we tested whether this scanner can be used to image the dopamine transporter adequately. Therefore, striatal phantom and patient data acquired on the InSPira were compared head-to-head with the well-validated brain-dedicated NeuroFocus system. A striatal phantom filled with [123I] and 14 subjects (after [123I]FP-CIT injection) were scanned on both systems. [123I]FP-CIT SPECT scans were visually assessed. Striatal binding ratios were calculated automatically using the software package BRASS. Striatal phantom and patient data showed strong correlations with respect to striatal ratios (R = 0.99 and R = 0.92; p < 0.05 and p < 0.01, respectively). Slightly higher ratios were found for the NeuroFocus patient data, probably due to differences in system performance. Visual assessment of [123I]FP-CIT scans showed agreement between systems in 13 of the 14 cases. We conclude that [123I]FP-CIT SPECT imaging can be performed adequately on the new InSPira system.

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ACR testing of a dedicated head SPECT unit

Cited by 9 publications

References 2 publications

Performance evaluation of a novel brain-dedicated SPECT system

Performance evaluation of a novel brain-dedicated SPECT system

Evaluation of external beam hardening filters on image quality of computed tomography and single photon emission computed tomography/computed tomography

Clinical evaluation of [123I]FP-CIT SPECT scans on the novel brain-dedicated InSPira HD SPECT system: a head-to-head comparison

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