Acral Lentiginous Melanoma

Bradford, Porcia T.; Goldstein, Alisa M.; McMaster, Mary L.; Tucker, Margaret A.

doi:10.1001/archdermatol.2008.609

Cited by 462 publications

(264 citation statements)

References 32 publications

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“…Across non-Caucasian subgroups, melanoma tends to result in greater morbidity and mortality because the disease is often identified at later, less treatable stages and because of low physician and patient awareness that melanomas do occur in these populations [12,13,14]. The most common cutaneous melanoma subtype in African-Americans, acral lentiginous melanoma, has a lower survival rate than other melanomas [15]. There is strong evidence that both genetic factors (very rare, highly penetrant mutations such as CDKN2A and common, low-penetrant genetic variants) and environmental ultraviolet exposure contribute to risk for development of melanoma [16,17,18].…”

Section: Introductionmentioning

confidence: 99%

Skin Cancer Concerns and Genetic Risk Information-Seeking in Primary Care

Hay

Kaphingst

Baser

et al. 2011

Public Health Genomics

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Background: Genomic testing for common genetic variants associated with skin cancer risk could enable personalized risk feedback to motivate skin cancer screening and sun protection. Methods: In a cross-sectional study, we investigated whether skin cancer cognitions and behavioral factors, sociodemographics, family factors, and health information-seeking were related to perceived importance of learning about how (a) genes and (b) health habits affect personal health risks using classification and regression trees (CART). Results: The sample (n = 1,772) was collected in a large health maintenance organization as part of the Multiplex Initiative, ranged in age from 25–40, was 53% female, 41% Caucasian, and 59% African-American. Most reported that they placed somewhat to very high importance on learning about how genes (79%) and health habits (88%) affect their health risks. Social influence actors were associated with information-seeking about genes and health habits. Awareness of family history was associated with importance of health habit, but not genetic, information-seeking. Conclusions: The investment of family and friends in health promotion may be a primary motivator for prioritizing information-seeking about how genes and health habits affect personal health risks and may contribute to the personal value, or personal utility, of risk information. Individuals who seek such risk information may be receptive to interventions aimed to maximize the social implications of healthy lifestyle change to reduce their health risks.

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Section: Introductionmentioning

confidence: 99%

Skin Cancer Concerns and Genetic Risk Information-Seeking in Primary Care

Hay

Kaphingst

Baser

et al. 2011

Public Health Genomics

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“…Basal cell carcinoma (BCC) is the most common type of skin cancer arising from the SB, usually induced as a result of prolonged UV exposure [38]. Figure 5 shows MPT and OCT images obtained from a sclerodermiform BCC, an aggressive growth variant of BCC, located on the forehead of a 71 year old female patient.…”

Section: Basal Cell Carcinomamentioning

confidence: 99%

Three‐dimensional multiphoton/optical coherence tomography for diagnostic applications in dermatology

Alex

Weingast

Weinigel

et al. 2012

Journal of Biophotonics

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A preliminary clinical trial using state‐of‐the‐art multiphoton tomography (MPT) and optical coherence tomography (OCT) for three‐dimensional (3D) multimodal in vivo imaging of normal skin, nevi, scars and pathologic skin lesions has been conducted. MPT enabled visualization of sub‐cellular details with axial and transverse resolutions of <2 μm and <0.5 μm, respectively, from a volume of 0.35 × 0.35 × 0.2 mm3 at a frame rate of 0.14 Hz (512 × 512 pixels). State‐of‐the‐art OCT, operating at a center wavelength of 1300 nm, was capable of acquiring 3D images depicting the layered architecture of skin with axial and transverse resolutions ∼8 μm and ∼20 μm, respectively, from a volume of 7 × 3.5 × 1.5 mm3 at a frame rate of 46 Hz (1024 × 1024 pixels). This study demonstrates the clinical diagnostic potential of MPT/OCT for pre‐screening relatively large areas of skin using 3D OCT to identify suspicious regions at microscopic level and subsequently using high resolution MPT to obtain zoomed in, sub‐cellular level information of the respective regions (© 2013 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)

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“…However, since the incidence of ALM in different races is quite similar, the prevailing belief is that ALM occurs at the same rate in all races [6,7,8,9,10]. ALM has a worse prognosis than other subtypes of melanoma, specifically superficial spreading melanoma and lentigo maligna melanoma [11,12]. This is primarily due to the fact that ALM is usually diagnosed at a later stage [13].…”

Section: Introductionmentioning

confidence: 99%

“…This is primarily due to the fact that ALM is usually diagnosed at a later stage [13]. Many factors seem to contribute to the delay in diagnosis: advanced age of patients, difficulty in exploring plantar sites and unusual presentation, not infrequently without pigmentation [11,12,13,14]. …”

Section: Introductionmentioning

confidence: 99%

Dermoscopy and Digital Dermoscopy Analysis of Palmoplantar ‘Equivocal’ Pigmented Skin Lesions in Caucasians

et al. 2012

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Background/Aim: The diagnosis of palmoplantar melanoma is often delayed and misdiagnosis is common, due to frequently unusual clinical presentation. We used a digital dermoscopy analyzer with a series of palmoplantar pigmented skin lesions (PP-PSL), and we compared sensitivity, specificity and diagnostic accuracy obtained with digital dermoscopy analysis (DDA) and classical dermoscopy. Methods: Digital dermoscopy images of 107 PP-PSL were retrospectively obtained from the database of images of 3 Italian centers. The lesions (25 melanomas and 82 nevi) were all removed because of the presence of clinical and/or dermoscopic suspicious features. All digital images were analyzed using appropriate algorithms, and the diagnostic accuracy of the model was calculated. For comparison, dermoscopic images were clinically evaluated by two dermatologists and the Cohen ĸ concordance with DDA was calculated. Results: The stepwise logistic regression analysis selected only 5 parameters out of 49. The logistic model achieved a sensitivity of 96% and a specificity of 87.8%. The Cohen ĸ concordance, evaluated by the Landis and Koch scale, supplied a substantial agreement between dermoscopy and DDA. Conclusions: DDA might be a useful diagnostic instrument in the evaluation of preselected PP-PSL. However, these findings should be confirmed in a formal clinical trial.

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Acral Lentiginous Melanoma

Cited by 462 publications

References 32 publications

Skin Cancer Concerns and Genetic Risk Information-Seeking in Primary Care

Skin Cancer Concerns and Genetic Risk Information-Seeking in Primary Care

Three‐dimensional multiphoton/optical coherence tomography for diagnostic applications in dermatology

Dermoscopy and Digital Dermoscopy Analysis of Palmoplantar ‘Equivocal’ Pigmented Skin Lesions in Caucasians

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