Acromegaly Presenting with Resistant Acne Vulgaris

Abstract

Acne vulgaris is one of the most frequent skin diseases worldwide, triggered by multiple endogenous and exogenous factors. Hormones, particularly growth hormone (GH), insulin-like growth factor-1, insulin, CRH, and glucocorticoids, play a major role in the pathogenesis and exacerbation of acne. Excess GH seen in acromegalic patients may result in increased size and function of sweat glands and sebaceous glands, which may contribute to the patient’s worsening acne and interfere with dermatologic treatment. Therefore, understanding the pathogenesis of acne will help in treating resistant acne by diagnosing and treating the underlying etiology using multidisciplinary treatment.

Effects of mesotherapy introduction of compound glycyrrhizin injection on the treatment of moderate to severe acne

“…23 In addition, some recent studies have suggested that the pathogenesis of acne is related to many factors, such as excessive sebum secretion caused by androgen and abnormal stimulation of sebaceous duct keratinization, lumen blockage, acne propionate infection, genetic background, and so on. 24 Androgen, especially dihydrotestosterone, is the initiating factor of acne. According to the different targets in the androgen metabolic pathway, antiandrogen therapy for acne tends to be divided into the following four categories: ovaries-derived androgen blockers, adrenal androgen blockers, androgen receptor antagonists, and enzyme inhibitors.…”

“…In order to improve the onset time of acne medication and reduce the incidence of complications, antibiotics and glucocorticoids for the treatment of acne are often used in combination with other drugs 23 . In addition, some recent studies have suggested that the pathogenesis of acne is related to many factors, such as excessive sebum secretion caused by androgen and abnormal stimulation of sebaceous duct keratinization, lumen blockage, acne propionate infection, genetic background, and so on 24 . Androgen, especially dihydrotestosterone, is the initiating factor of acne.…”

Effects of natural products on skin inflammation caused by abnormal hormones secreted by the adrenal gland

“…It is determined by physiological changes associated with hair cycle, ultraviolet radiation exposure, immune cytokine release, or the presence of cutaneous pathology ( Bocheva et al, 2019 ; Ocampo-Garza et al, 2020 ). Previous work shows that the level of CRH is increased in acne-involved skin, especially in the sebaceous glands, possibly activating pathways which affect immune and inflammatory processes leading to the development and stress-induced exacerbation of acne ( Ganceviciene et al, 2009 ; Khamdan et al, 2022 ).…”