Acrometastasis as the Initial Presentation of Lung Adenocarcinoma in a Young Woman

Sarasúa, Luis Gorospe; Pérez, Laura Mezquita; Blanco, R.

doi:10.1016/j.arbr.2016.07.001

Cited by 3 publications

(3 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Overall, AMs are associated with poor prognosis, with 6–8-month overall survival [ 7 – 9 , 25 ]. Indeed, AMs are usually a sign of multimetastatic involvement.…”

Section: Discussionmentioning

confidence: 99%

Solitary acrometastasis of the phalanx as initial presentation of an oligometastatic Kirsten rat sarcoma viral oncogene homolog-mutated lung adenocarcinoma: a case report

Pușcașu,

Moinard-Butot,

Antoni

et al. 2023

J Med Case Reports

View full text Add to dashboard Cite

Background Acrometastasis is an uncommon finding in non-small cell lung cancer and is usually a sign of multimetastatic disease. Few case reports have suggested solitary digital metastasis as the single secondary lesion of oligometastatic non-small cell lung cancer. Case presentation This case report describes an unusual presentation of a Kirsten rat sarcoma viral oncogene homolog-mutated lung adenocarcinoma with a solitary bone metastasis in the fourth finger medial phalanx, which was also the first sign of the disease, in a 63-year-old Caucasian female patient. Digital surgical amputation was performed. After histopathological confirmation and radiological exclusion of other secondary lesions, chemoimmunotherapy in a first-line setting was initiated. A partial metabolic response in the primary lung lesion was observed after four cycles. Maintenance therapy is currently being continued. Conclusion Solitary digital metastasis is a rare finding in non-small cell lung cancer. Further studies are needed to investigate the mechanisms behind this particular dissemination process.

show abstract

“…Overall, AMs are associated with poor prognosis, with 6–8-month overall survival [ 7 – 9 , 25 ]. Indeed, AMs are usually a sign of multimetastatic involvement.…”

Section: Discussionmentioning

confidence: 99%

Solitary acrometastasis of the phalanx as initial presentation of an oligometastatic Kirsten rat sarcoma viral oncogene homolog-mutated lung adenocarcinoma: a case report

Pușcașu,

Moinard-Butot,

Antoni

et al. 2023

J Med Case Reports

View full text Add to dashboard Cite

show abstract

“…Symptoms and signs are variable and may include swelling, erythema, fracture, pain, numbness, heat, or even persistent infection and ulceration, often leading to misdiagnosis of a metabolic condition or soft tissue infection. 8 Radiographs usually show osteolytic lesions except in some osteoblastic lesions of acrometastasis from prostatic cancer. Biopsy or fine-needle aspiration cytology leads to an accurate diagnosis.…”

Section: Discussionmentioning

confidence: 99%

“…Any type of malignant tumor can produce acrometastasis, and metastasis from the lungs has been reported in >40% of cases. 8 Kidney and breast cancers are the next most common primary tumors. Malignant neoplasms from these three sites account for two-thirds of cases of acrometastasis.…”

Section: Discussionmentioning

confidence: 99%

Acrometastasis of nasopharyngeal carcinoma: a case report

Jiang

Zhou

et al. 2020

J Int Med Res

View full text Add to dashboard Cite

Acrometastasis is an exceedingly rare condition and is often misdiagnosed or overlooked. We herein describe a 50-year-old patient who developed acrometastasis in the big toe from nasopharyngeal carcinoma. The treatment consisted of amputation through the proximal phalanx, and the patient recovered well. To our knowledge, only one case of acrometastasis from this origin has been reported in the literature to date. Acrometastasis indicates a poor prognosis, and we should choose appropriate treatment to relieve symptoms and benefit the patient.

show abstract

Acrometastases to the Hand: A Systematic Review

et al. 2021

View full text Add to dashboard Cite

Background and Objectives: The term acrometastases (AM) refers to secondary lesions sited distally to the elbow and knee, representing 0.1% of all bony metastases. By frequency, pulmonary cancer and gastrointestinal and genitourinary tract neoplasms are the most responsible for the reported AM. Improvements in oncologic patient care favor an increase in the incidence of such rare cases. We performed a systematic review of acrometastases to the hand to provide further insight into the management of these fragile patients. We also present a peculiar case of simultaneous acrometastasis to the ring finger and pathological vertebral fracture. Material and Methods: A literature search according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) statement was conducted using the PubMed, Google Scholar, and Scopus databases in December 2020 on metastasis to the hand and wrist, from 1986 to 2020. MeSH terms included acrometastasis, carpal metastasis, hand metastasis, finger metastasis, phalangeal metastasis, and wrist metastasis. Results: In total, 215 studies reporting the follow-up of 247 patients were analyzed, with a median age of 62 years (range 10–91 years). Overall, 162 out of 247 patients were males (65.6%) and 85 were females (34.4%). The median reported follow-up was 5 months (range 0.5–39). The median time from primary tumor diagnosis to acrometastasis was 24 months (range 0.7–156). Acrometastases were located at the finger/phalanx (68.4%), carpal (14.2%), metacarpal (14.2%), or other sites (3.2%). The primary tumors were pulmonary in 91 patients (36.8%). The average interval from primary tumor diagnosis to acrometastasis varied according to the primary tumor type from 2 months (in patients with mesenchymal tumors) to 64.0 months (in patients with breast cancer). Conclusions: Acrometastases usually develop in the late stage of oncologic disease and are associated with short life expectancy. Their occurrence can no longer be considered rare; physicians should thus be updated on their surgical management and their impact on prognosis and survival.

show abstract

Acrometastasis as the Initial Presentation of Lung Adenocarcinoma in a Young Woman

Cited by 3 publications

References 1 publication

Solitary acrometastasis of the phalanx as initial presentation of an oligometastatic Kirsten rat sarcoma viral oncogene homolog-mutated lung adenocarcinoma: a case report

Solitary acrometastasis of the phalanx as initial presentation of an oligometastatic Kirsten rat sarcoma viral oncogene homolog-mutated lung adenocarcinoma: a case report

Acrometastasis of nasopharyngeal carcinoma: a case report

Acrometastases to the Hand: A Systematic Review

Contact Info

Product

Resources

About